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Register a new userIgG4 Deficiency in Childhood Asthma
نقص الغلوبولين المناعي IgG4 في الربو عند الأطفال
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Damascus University ورقة بحثية
Publication date
2009
fields
Medicine
and research's language is
العربية
Authors
مأمون حكيم( باحث )
Created by
Shamra Editor
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يعد الربو أهم الأمراض المزمنة عند الأطفال، و هو في ازدياد و يشكل مشكلة صحة عامة تتطلب البحث عن العوامل التي تزيد نسبة الحدوث و شدة النوب، و من هذه العوامل نقص IgG4 . و لذلك كان هدف الدراسة معرفة تأثير نقص IgG4 في شدة تطور الربو عند الأطفال.
Asthma is the most common chronic disease in childhood, the incidence progresses and constitutes a public health problem which needs the research of factors that increase the incidence and severity of crisis, and among these factors IgG4 deficiency. Therefore the objective of the study is to know the effect of IgG4 deficiency on severity and evolution of asthma in children.
References used
Daniel L et al. Hypogammaglobuliemia in asthmatic patients, Annals of Allergy 1992 June, volume 68: 472-81
Moss RB et al. Deficiency of IgG4 in children: association of isolated IgG4 deficiency with recurrent respiratory tract infection, J Pediatr 1992 Jan, 120 (1): 16-21
Heiner DC et al. Deficiency of IgG4: a disorder associated with frequent infections and bronchiectasis that may be familial. Clin Rev Allergy 1983; 1: 259
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Background& Objective: Selective IgA deficiency is the most common primary immunodeficiency in
humans. Its prevalence ranges from 1 in 100 to 1 in 1000 in among Arab populations. The majority of
patients with selective IgA deficiency are asymptomat
ic. The remaining present with recurrent upper and
lower respiratory tract infections, recurrent gastrointestinal infections, otitis media, sinusitis, celiac
disease, giardiasis, allergic disorders and some autoimmune diseases.
to highlight the clinical manifestations and laboratory findings of Selective IgA deficiency in our study,
and to compare it with medical literature. To study the bacterial complications and their prevalence.
Materials & Methods: A retrospective study was carried out in Damascus University Children’s Hospital
on sixteen child diagnosed as Selective IgA deficiency, in a period of the last ten years (from 2000 till
September 2010).
Results: most cases in our study were among males, failure to thrive was found in 75%,
hepatosplenomegaly in one third, the most prominent infectious complications were: recurrent pneumonia
(in 87.5% of cases), recurrent GI infections (in 75% of cases) and UTI’s in (50%)of cases. On the other
hand, the celiac disease was found in (25%) of our patients, which is much higher than described in
medical literature. In general, the infectious complications had a good response to antibacterial therapy,
and the IgA levels became normal in one patient, when he reached the age of eleven years.
Conclusion: there is no information in medical literature about the association of selective IgA deficiency
with hepatomegaly, splenomegaly, failure to thrive and an increased prevalence of urinary tract
infections, therefore, it is necessary to conduct researches about this association.
This study was done to determine whether use of nebulized salbutamol therapy for
treatment of an acute attack of asthma in children is associated with hypokalaemia and if
so what is its frequency, severity and what is accompanying clinical symptoms
103 child,
aged 3 years to 14 years with asthma attack, treated with three doses of nebulized
salbutamol 0.15mg/kg, every 20 min participated in the study. Blood for serum potassium
was obtained at the beginning and after three doses of nebulized salbutamol therapy.The
mean serum potassium level decreased from 3.94 mEq/L to 3.28 mEq/L (P < 0.05). A
decrease in serum potassium concentration was noted in 93 child (90.3%).). Mild
hypokalemia formed the highest proportion in 43child (41.7%) followed by moderate
hypokalemia in 28 child( 27.2%). Severe hypokalemia did not happen.This decrease was
accompanied with clinical symptoms (palpitations 23,muscle weakness 21,nausea 15,
headache 12,myalgia 11,vomiting 9).These symptoms were moreclosely to moderate
hypokalemia.
Hyperimmunoglobulin E (Job) syndrome is considered to be a relatively rare
disease. Its characterized by recurrent infections in skin (eg. boils, abscesses), recurrent upper respiratory
tract infections (eg. otitis media, sinusitis and mastoiditis)
, and lower respiratory infections (eg. recurrent
pneumonia, which is often complicated by pneumatoceles and lung abscess), that are usually difficult to
treat. The highly increased IgE levels are considered to be the hallmark of the disease. The syndrome has
two types: one is inherited as an autosomal recessive, and the other, as an autosomal dominant trait.
To highlight the clinical manifestations and laboratory findigs of Job disease, and to compare it with
medical literature, to study the bacterial complications and differrent types of antibacterial treatments
and treir results, and to increase the level of awareness among physicians.
the research performed by the ITP study group in 2006[15] studying the efficacy
of single dose IV-Rhesus antibodies (Anti-D) "50 ug/kg or 75 ug/kg" compared to the single dose IVIG
"800 mg/kg"; that study revealed that both have a similar therapeutic effect. that study suggest to compare the single high dose of Anti-D withthree consecutive doses of Methyl-prednisolone in respect of:
1- Time of platelet recovery
2- The continuity of mediation effect throughout ( 6 months)
3- Side effects, hospitalization and cost.
This study was conducted to investigate the relationship between estrogen
depletion ,calcium-deficiency,and alveolar bone loss.
Alveolar bone loss was evaluated by radiographic and visual inspection of
rabbits with experimental lack of estrogen an
d calcium.
Twenty female local rabbits (4 months old) were divided into four groups
:group a -ovariectomized and given a standard solid diet.
Group b-ovariectomized and given a calcium – deficient diet
Group c-sham-ovariectomized and given a standard solid diet.
And group d-sham-ovariectomized and given a calcium-deficient diet
after 8 weeks,the rabbits were sacrificed .
The maxillae, mandibles, femurs, and tibias were removed carfully and
fixed in 10% neutral buffered formalin. The bone mineral density of each
bone and the alveolar bone loss were measured.the bone meniral densities of
the maxillae,mandibles,femurs and tabias in group (c) were significantly
higher than those in groups (b)and (d),but not higher than those in group
a.however there were no significant differences between any of the groups
with regard to alveolar bone loss from the cemento-enamel junction to the
molar bone crest.
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