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Register a new userLevels of YKL-40 in Patients with Coronary Heart Disease in Syria
مستويات YkL-40 لدى مصابين بأمراض القلب التاجية في سورية
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Damascus University رسالة ماجستير
Publication date
2015
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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تأكد دور العملية الالتهابية في التصلب العصيدي وتطوره حيث تتدخل العديد من العوامل الالتهابية في عملية الالتهاب الوعائي والذي يؤدي إلى أذية البطانة والتي هي الحدث المبكر في عملية التصلب العصيدي
The role of the inflammatory process in atherosclerosis and its development has been confirmed, as many inflammatory factors intervene in the vasculitis process, which leads to damage to the endothelium, which is the early event in the process of atherosclerosis.
Artificial intelligence review:
Research summary
تتناول هذه الدراسة مستويات بروتين YKL-40 في مرضى القلب التاجي في سوريا. يُعتبر YKL-40 بروتينًا سكريًا مرتبطًا بالالتهابات ويُعتقد أنه يلعب دورًا في تطور التصلب العصيدي. هدفت الدراسة إلى تقييم مستويات YKL-40 لدى مرضى القلب التاجي ومقارنة هذه المستويات مع مجموعة من الأصحاء. شملت الدراسة 36 مريضًا باحتشاء عضلة القلب، 30 مريضًا بالذبحة المستقرة، و24 شخصًا من الأصحاء. تم قياس مستويات YKL-40 في المصل باستخدام تقنية ELISA. أظهرت النتائج ارتفاعًا كبيرًا في مستويات YKL-40 لدى مرضى الاحتشاء والذبحة مقارنة بالأصحاء. كما أظهرت الدراسة وجود علاقة ارتباط إيجابية بين YKL-40 و hs-CRP، وعدم وجود علاقة ارتباط مع CK-MB لدى مرضى الاحتشاء. بالإضافة إلى ذلك، أظهرت الدراسة وجود علاقة ارتباط إيجابية بين YKL-40 و TG لدى مرضى الذبحة المستقرة، وعدم وجود علاقة ارتباط مع الكوليسترول الكلي و HDL و LDL. خلصت الدراسة إلى أن YKL-40 يمكن أن يكون واصمًا مهمًا لمراقبة العلاج لدى مرضى القلب التاجي، حيث أن قيمه مستقلة عن مستويات الكوليسترول، مما يجعله أكثر دقة من hs-CRP في هذا السياق.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة في فهم دور بروتين YKL-40 في أمراض القلب التاجية، إلا أنها لم تخلُ من بعض النقاط التي تحتاج إلى توضيح أو تحسين. أولاً، حجم العينة كان صغيرًا نسبيًا، مما قد يؤثر على تعميم النتائج. ثانياً، لم يتم تناول تأثير العوامل البيئية والغذائية بشكل كافٍ، والتي قد تؤثر على مستويات YKL-40. ثالثاً، كان من المفيد تضمين مجموعة أكبر من المتغيرات السريرية والبيوكيميائية لتحليل أعمق. أخيرًا، يجب إجراء دراسات مستقبلية تشمل عينات أكبر وتنوعًا جغرافيًا أوسع للتحقق من هذه النتائج وتعزيزها.
Questions related to the research
-
ما هو الهدف الرئيسي من هذه الدراسة؟
الهدف الرئيسي من الدراسة هو تقييم مستويات بروتين YKL-40 لدى مرضى القلب التاجي ومقارنة هذه المستويات مع مجموعة من الأصحاء.
-
ما هي التقنية المستخدمة لقياس مستويات YKL-40 في المصل؟
تم استخدام تقنية ELISA لقياس مستويات YKL-40 في المصل.
-
ما هي العلاقة بين YKL-40 و hs-CRP التي أظهرتها الدراسة؟
أظهرت الدراسة وجود علاقة ارتباط إيجابية بين YKL-40 و hs-CRP.
-
هل أظهرت الدراسة أي علاقة بين YKL-40 و CK-MB لدى مرضى الاحتشاء؟
لا، لم تظهر الدراسة أي علاقة ارتباط بين YKL-40 و CK-MB لدى مرضى الاحتشاء.
References used
Rastam S, al Ali R, et al. Explaining the increase in coronary heart disease mortality in Syria between 1996 and 2006. BMC Public Health. 2012
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