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Register a new userLevels of YKL-40 in Patients with Coronary Heart Disease in Syria
مستويات YkL-40 لدى مصابين بأمراض القلب التاجية في سورية
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Damascus University رسالة ماجستير
Publication date
2015
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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تأكد دور العملية الالتهابية في التصلب العصيدي وتطوره حيث تتدخل العديد من العوامل الالتهابية في عملية الالتهاب الوعائي والذي يؤدي إلى أذية البطانة والتي هي الحدث المبكر في عملية التصلب العصيدي
The role of the inflammatory process in atherosclerosis and its development has been confirmed, as many inflammatory factors intervene in the vasculitis process, which leads to damage to the endothelium, which is the early event in the process of atherosclerosis.
References used
Rastam S, al Ali R, et al. Explaining the increase in coronary heart disease mortality in Syria between 1996 and 2006. BMC Public Health. 2012
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Heart disease is the leading cause of death in the world over the past 10 years. Researchers have been using several data mining techniques to help health care
professionals in the diagnosis of heart disease. Decision Tree is one of the successful d
ata mining techniques used. However, most research has applied J4.8 Decision Tree, based on Gain Ratio and binary discretization. Gini Index
and Information Gain are two other successful types of Decision Trees that are less used in the diagnosis of heart disease. Also other discretization techniques, voting method, and reduced error pruning are known to produce
more accurate Decision Trees. This research investigates applying a range of techniques to different types of Decision Trees seeking better performance in heart disease diagnosis. A widely used benchmark data set is
used in this research. To evaluate the performance of the alternative Decision Trees the sensitivity, specificity, and accuracy are calculated. The research proposes a model that outperforms J4.8 Decision Tree and Bagging algorithm in the diagnosis of heart disease patients.
Background: longitudinal and radial systolic function are weakened by cardiac diseases and
longitudinal one is weakened first. Assessment of left ventricular LV systolic function is important
in management and prognosis of cardiac diseases. Mitral
annular displacement MAD is used to
assess LV longitudinal and global systolic function.
Objectives: To validate the accuracy of MAD assessed by Doppler tissue imaging DTI and
m-mode echocardiography MME as a surrogate for determination of LV systolic function in
pationts with ischemic heart disease and/or heart failure, and maybe easy and fast way instead of
conventional echocardiography assessment of LV function. This way permits to study the function
of LV longitudinal cardiac fibers function while the conventional ways of echocardiography
assesses the circumferential shortening.
Patients and methods: We studied a series of 96 patients (men and women) with (ischemic
heart diseases,heart failure) divided into three age groups and compared with another 59 healthy
age matched volunteers as a control group. We selected subjects from AL ASSAD hospital
/LATAKIA over the year 2014. A medical history, whole medical examination, ECG, conventional
echocardiography were made to each subject. Ejection fraction EF of LV, Doppler recording of the
mitral inflow, MME and pulse wave Doppler tissue imaging PW DTI data (from each four sites of
mitral annulus, anterior, septal, lateral and inferior) were obtained. Mean peak systolic velocity (S
wave), mean annular early diastolic velocity (e') by PW DTI and mean mitral annular displacement
(MAD) by MME were calculated by averaging of values measured at each annular site.
Results: MAD correlate well with LV EF, mean MAD < 11.275 mm determined by MME
has 85% sensitivity and 87.8% specificity and 85.8% accuracy for detection of LV EF < 50%, Mad
was low in patients with infarctions and lower in pationts with heart failure.
Conclusion: Mean MAD connect with a positive relationship with LV EF and can detect the
abnormal systolic motion on the long axis. That means the ability to detect the ischemia in early
stages.
Prenatal detection of congenital heart disease is possible from the 16th week of
pregnancy. the ideal time being the Midtrimester ,when the most cardiac abnormalities can be detected
,where all routine cross sectional views are easily obtainable.
To evaluate the detection and accuracy of fetal echocardiography for congenital heart defects among high
risk pregnancies.
In contrast to adaptive immunity and to certain components of innate immunity, only little is known on the influence of the complement system on cancer suppression and promotion . The lectin pathway of complement activation is an important part of in
nate immunity. It is mainly involved in opsonisation and lysis of pathogens and in recruitment of inflammatory cells.
Our study aimed to assess the relationship between MASP-2 serum levels before and after chemotherapy in Syrian children with acute lymphoblastic leukemia, aiming to find a relation, which serve in early forecast of patients response to chemotherapy, where the study has been done at Children University Hospital in damascus between 2013-2014. This study included 37 children diagnosed with acute lymphoblastic leukemia (ALL). The levels of Mannose-Binding Lectin-associated Serine Protease-2 (MASP-2) were determined by Enzyme Linked Immuno Sorbent Assay (ELISA).
The result was that serum levels of MASP-2 was strongly reduced after chemotherapy in children with acute lymphoblastic leukemia, and a strong correlation between serum marker levels before and after chemotherapy was found.
Hepatocellular carcinoma (HCC) is a common malignancy and the
leading cause of death worldwide, due to late detection and high
recurrence rates. Osteopontin (OPN) has various functions,
including prevention of apoptosis and modulation of angiogene
sis
which lead to tumor formation and progression, although the exact
mechanisms for the development of cancer are still unknown.
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