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Register a new userMASP-2 serum levels in Syrian children with Acute lymphoblastic leukemia
مستويات MASP-2 المصليّة عند أطفال سوريين مصابين بابيضاض الدم اللمفاوي الحاد
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Tishreen University ورقة بحثية
Publication date
2015
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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خلافاً للمناعة التلاؤمية و مكونات معينة من المناعة الخلقية، قليل ما هو معلوم عن وظيفة جملة المتممة في تعزيز و كبت السرطان. يُعتبر سبيل الليكتين لتفعيل المتممة جزءاً هاماً من المناعة الخلقية. إنه مكتنف بشكل رئيسي في طهاية و انحلال الممراضات و توظيف الخلايا الالتهابية. تهدف دراستنا إلى تقييم العلاقة بين المستويات المصلية لبروتياز السيرين المشارك لليكتين الرابط للمانوز -2 (MASP-2) قبل و بعد المعالجة الكيميائية عند أطفال سوريين مصابين بابيضاض الدم اللمفاوي الحاد (ALL) acute lymphoblastic leukemia بهدف إيجاد علاقة تساعد في التنبؤ المبكر لاستجابة المرضى للمعالجة الكيميائية، حيث تمت الدراسة بين عامي 2013 و 2014 في مستشفى الأطفال الجامعي بدمشق و شملت 37 طفلاً مشاركاً مصاباً بابيضاض الدم اللمفاوي الحاد، حيث تم قياس مستويات بروتياز السيرين المشارك لليكتين الرابط للمانوز-2 (MASP-2) المصلية بطريقة الممتز المناعي المرتبط بالإنزيم (ELISA). فكانت النتيجة أن وُجِدَ أن مستويات MASP-2 المصليّة قد انخفضت بشكل ملحوظ بعد المعالجة الكيميائية عند الأطفال المصابين بابيضاض الدم اللمفاوي الحاد، و كذلك وُجِدَ علاقة ارتباط قوية بين مستويات الواسم قبل و بعد المعالجة.
In contrast to adaptive immunity and to certain components of innate immunity, only little is known on the influence of the complement system on cancer suppression and promotion . The lectin pathway of complement activation is an important part of innate immunity. It is mainly involved in opsonisation and lysis of pathogens and in recruitment of inflammatory cells. Our study aimed to assess the relationship between MASP-2 serum levels before and after chemotherapy in Syrian children with acute lymphoblastic leukemia, aiming to find a relation, which serve in early forecast of patients response to chemotherapy, where the study has been done at Children University Hospital in damascus between 2013-2014. This study included 37 children diagnosed with acute lymphoblastic leukemia (ALL). The levels of Mannose-Binding Lectin-associated Serine Protease-2 (MASP-2) were determined by Enzyme Linked Immuno Sorbent Assay (ELISA). The result was that serum levels of MASP-2 was strongly reduced after chemotherapy in children with acute lymphoblastic leukemia, and a strong correlation between serum marker levels before and after chemotherapy was found.
References used
FINN OJ. Cancer immunology. N Engl J Med. 2008;358:2704–15
MARKIEWSKY MM, LAMBRIS JD. Is complement good or bad for cancer patients? A new perspective on an old dilemma. Trends Immunol. 2009;30:286–92
THIEL S. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol Immunol. 2007;44:3875–88
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Chemotherapy causes neutropenia and increase susceptibility to infections. Morbidity and mortality due to infections remain serious problem in children with cancer. Decreased serum levels of Mannose-binding lectin ( MBL) may represent a risk factor f
or infections in children with acute lymphoblastic leukemia receiving chemotherapy.
The aim of this study was to determine whether low MBL levels is associated with increased risk of infections in Syrian children with acute lymphoblastic leukemia.
The study has been done at Children University Hospital in Damascus between 2013-2014. This study included 37 children diagnosed with acute lymphoblastic leukemia (ALL) who were candidates for chemotherapy, and the infections were identified depending on patients files. The levels of Mannose-Binding Lectin (MBL) was determined by Enzyme Linked Immuno Sorbent Assay (ELISA).
The result was that MBL serum levels are higher in patients who did not develop infections compared to patients who developed infections, and all patients with low MBL levels developed infections in contrast to patients with normal MBL serum levels.
This study aimed to
investigate the validity of measuring IGFBP-3 in the serum of
Syrian children with acute lymphoblastic leukemia (ALL) as
additional markers in diagnosis and follow-up of the disease.
Our study aimed to evaluating significance of survivin as a
prognostic marker of relapse in children with acute lymphoblastic
leukemia. The study included 46 child (30 males, 16 females): 24
child with ALL at 35 day from BFM 95 Protocol and 22 rel
apse
child with ALL.
Serglycin is an intracellular proteoglycan in hematopoietic cells. It
has been studied in normal and tumor hematopoietic cell, so it was
suggested to have an important role in immunity and cancers as leukemia.
The challenge to make a diagnosis for
acute leukemia and to
differentiate between myeloid or lymphoblastic leukemia, is the reason
we go to assay concentration of serglyc in normal people and
patient with acute myeloid leukemia and acute lymphoblastic leukemia
from children and adult at hematology department in the
main hospitals in Damascus ( Pediatric’shopital, Almouasat and Al
asaad hospital) before beginning any kind of treatment and studying
the relation with white blood cells count. We found clear difference
between the concentration in patient with acute leukemia and normal
people. There was a high level of this marker in paint with
AML in contrast with ALL patients. We found a relation between
concentration of serglycin and the count of white blood cells.
Relapse of acute lymphoblastic leukemia (ALL) in the central nervous system
(CNS) in adults is considered a poor prognostic feature. Few reports have analyzed this issue. The
objective of this study was to estimate the experience with CNS recurrence in adult patients with ALL,
then to choose the best therapy.
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