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Register a new userMeasuring Levels of Osteopontin in a Sample of Hepatocellular Carcinoma Patients
مقايسة مستويات الأوستيوبونتين البلازميّة لدى عيّنة من مرضى سرطان الخلية الكبدية
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يعد سرطان الكبد من الخباثات الشائعة، و من أحد أهم الأسباب المؤدية للوفاة بالسرطان في العالم و ذلك بسبب الكشف المتأخر و نسبة النكس العالية. و ان لأرتفاع قيم الأوستيوبونتين دور في نشوء و تطور سرطان الكبد حيث يساهم في وظائف مختلفة منها الوقاية من الموت المبرمج للخلايا (apoptosis) و تشكل الأوعية الدموية (angiogenesis) على الرغم من أن الأليات الدقيقة لتطور السرطان مازالت غير معروفة. حيث يزداد تركيزه بشكلٍ مبكرٍ في البلازما لدى مرضى سرطان الكبد مقارنةً بالأسوياء مما قد يفيد في استخدامه كواصم مبكر لتشخيص هذا النوع من السرطانات.
Hepatocellular carcinoma (HCC) is a common malignancy and the leading cause of death worldwide, due to late detection and high recurrence rates. Osteopontin (OPN) has various functions, including prevention of apoptosis and modulation of angiogenesis which lead to tumor formation and progression, although the exact mechanisms for the development of cancer are still unknown.
References used
CAO DX, et al. 2012 Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers, World J Gastroenterol, Vol.18(30),3923-3930
SALEM M, et al. 2013 Clinical Significance of Plasma Osteopontin Level as a Biomarker of Hepatocellular Carcinoma, Gastroenterology Research, Vol.6(5),191-199
LUO X, et al. 2011 Osteopontin Stimulates Preneoplastic Cellular Proliferation Through Activation of the MAPK Pathway, Mol Cancer Res, Vol.9,1018-1029
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