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Register a new userDevelopment and Evaluation of Phenytoin Loaded Chitosan Nanoparticles using Different Formulation Methods for Anti-epileptic and Intranasal Delivery Applications
تطوير وتقييم جسيمات الكيتوزان النانوية المحملة بمادة الفنتوئين والمصنعة بطرائق صياغة مختلفة للتطبيقات المضادة للصرع والإيصال الأنفي
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Added by
Tishreen University ورقة بحثية
Publication date
2021
fields
Medicine
and research's language is
العربية
Created by
Shamra Editor
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تم الاهتمام بالجسيمات النانوية البوليمرية في السنوات الأخيرة كأنظمة دوائية واعدة للتوصيل عبر المخاطيات الحيوية والاستهداف الدماغي متضمنة جسيمات الكيتوزان لما تتمتع به من مزايا وأهمها الخواص اللصوقة حيوياً. تركّز الهدف من الدراسة المقدمة على تحضير جسيمات الكيتوزان النانوية وتقييم خواص الجسيمات الناتجة وفقاً لكفاءة كبسلتها وأبعادها الناتجة وفق طريقة التحضير المتبعة. تم استخدام طرائق التصالب الشاردي في الأوساط المائية وطرائق الاستحلاب بنفاذ المحل وبتبخر المحل وطريقة الترسيب النانوية وقد أبدت طريقة الترسيب النانوي المعتمدة على حل الكيتوزان في الوسط المائي وحل الليسيتين والفنتوئين في الوسط العضوي الفعالية الأكبر بكبسلة المادة الدوائية المدروسة إذ بلغت 67% بحجم أبعاد بلغ 311.3 نانومتر. تعد هذه النتائج أولية ولكنها واعدة لأمثلة الشروط التصنيعية للوصول لأفضل خواص فيزيوكيميائية للجسيمات المصنعة ودراسة فعاليتها في تحقيق الاستهداف الدماغي بعد تجريعها بالطريق الأنفي.
In recent years, attention has been given to polymeric nanoparticles as promising drug delivery systems through the vital mucus and the development of several drug delivery systems to the brain, including chitosan nanoparticles because of their advantages, which are the bio-adhesive properties. The aim of the presented study focuses on preparing chitosan nanoparticles and evaluating the properties of the resulting particles according to the encapsulation efficiency and resulting dimensions. The methods of ionic cross linking, emulsification with solvent diffusion and evaporation, and nanopricipitation methods were employed to produce the nanoparticles. The nanopricipitation method based on adding organic phase contained lecithin and phenytoin to the chitosan solution in aqueous medium showed the greatest encapsulation efficiency (EE%) reaching 67% with dimensions of 311.3nm. These results are preliminary, but they are promising for determination of manufacturing conditions to reach the best physicochemical properties of the prepared particles and to study their effectiveness in brain targeting after being administrated via the nasal route.
References used
Sternling, C.V. and L.E. Scriven, Interfacial turbulence: Hydrodynamic instability and the marangoni effect. AIChE Journal, 1959. 5 (4): p. 5 14 - 523
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