مقارنة نجاعة ومأمونية نظم الأنسولين المستخدمة في تدبير فرط سكر الدم لدى مرضى السكري من النمط الثاني في المستشفيات
تم توجيه الكثير من الاهتمام إلى تاثير محتويات الأغذية المتنوعة على استقلاب وفعالية الأدوية عند المرضى في السنوات الأخيرة
In recent years, attention has been given to polymeric nanoparticles as promising drug delivery systems through the vital mucus and the development of several drug delivery systems to the brain, including chitosan nanoparticles because of their advan
tages, which are the bio-adhesive properties. The aim of the presented study focuses on preparing chitosan nanoparticles and evaluating the properties of the resulting particles according to the encapsulation efficiency and resulting dimensions. The methods of ionic cross linking, emulsification with solvent diffusion and evaporation, and nanopricipitation methods were employed to produce the nanoparticles. The nanopricipitation method based on adding organic phase contained lecithin and phenytoin to the chitosan solution in aqueous medium showed the greatest encapsulation efficiency (EE%) reaching 67% with dimensions of 311.3nm. These results are preliminary, but they are promising for determination of manufacturing conditions to reach the best physicochemical properties of the prepared particles and to study their effectiveness in brain targeting after being administrated via the nasal route.
Background: Inappropriate prescriptions are important risk factors associated with increased adverse drug effects, morbidity, and depletion of health care resources for the elderly patient community, then the development of Beyer criteria as a reference and an approved general framework for assessing the safety of drug care administered to the elderly.
