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Register a new userدراسة انتشار التأثيرات الضائرة للأدوية المضادة للصرع على الكثافة المعدنية للعظام عند مرضى الصرع
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Tishreen University رسالة ماجستير
Publication date
2016
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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تبين الإحصائيات الطبية ان مرضى الصرع أكثر عرضة للكسور بضعفين إلى ستة أضعاف مقارنة بأقرانهم الأصحاء المماثلين لهم جنساً وعمراً
No English abstract
Artificial intelligence review:
Research summary
تهدف هذه الدراسة إلى تقييم التأثيرات الضارة للأدوية المضادة للصرع على الكثافة المعدنية للعظام لدى مرضى الصرع في سوريا، مع التركيز على دواءين شائعين هما الفالبروات واللاموتريجين. تم إجراء دراسة مقطعية على 69 مريضًا بالصرع يتناولون أحد هذين الدواءين لمدة لا تقل عن سنة، وتمت مقارنة نتائجهم مع 50 شخصًا سليمًا من نفس العمر والجنس. أظهرت النتائج انخفاضًا ملحوظًا في الكثافة المعدنية للعظام لدى المرضى مقارنة بالأصحاء، خاصة في مجموعة الفالبروات. كما تبين أن 98.5% من المرضى يعانون من نقص فيتامين D، وهو ما يعكس مشكلة صحية واسعة الانتشار. أوصت الدراسة بضرورة اتخاذ إجراءات وقائية وعلاجية لتحسين صحة العظام لدى مرضى الصرع، بما في ذلك تناول مكملات الكالسيوم وفيتامين D.
Critical review
تعتبر هذه الدراسة خطوة هامة في فهم التأثيرات الضارة للأدوية المضادة للصرع على صحة العظام، ولكنها ليست خالية من العيوب. أولاً، كان حجم العينة صغيرًا نسبيًا، مما قد يؤثر على تعميم النتائج. ثانياً، لم يتم استخدام تقنيات تصوير شعاعي للكشف عن الكسور غير العرضية، مما قد يؤدي إلى تقدير غير دقيق لمعدل الكسور. ثالثًا، لم يتم النظر في تأثير العوامل الوراثية التي قد تؤثر على صحة العظام. وأخيرًا، كان من الأفضل تضمين مجموعة من المرضى الذين يتناولون أدوية مضادة للصرع أخرى للمقارنة.
Questions related to the research
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ما هو الهدف الرئيسي من هذه الدراسة؟
الهدف الرئيسي هو تقييم التأثيرات الضارة للأدوية المضادة للصرع على الكثافة المعدنية للعظام لدى مرضى الصرع في سوريا، مع التركيز على دواءين شائعين هما الفالبروات واللاموتريجين.
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ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟
أظهرت الدراسة انخفاضًا ملحوظًا في الكثافة المعدنية للعظام لدى المرضى مقارنة بالأصحاء، خاصة في مجموعة الفالبروات. كما تبين أن 98.5% من المرضى يعانون من نقص فيتامين D.
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ما هي التوصيات التي قدمتها الدراسة؟
أوصت الدراسة بضرورة اتخاذ إجراءات وقائية وعلاجية لتحسين صحة العظام لدى مرضى الصرع، بما في ذلك تناول مكملات الكالسيوم وفيتامين D.
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ما هي العيوب الرئيسية في هذه الدراسة؟
العيوب تشمل حجم العينة الصغير، عدم استخدام تقنيات تصوير شعاعي للكشف عن الكسور غير العرضية، عدم النظر في تأثير العوامل الوراثية، وعدم تضمين مجموعة من المرضى الذين يتناولون أدوية مضادة للصرع أخرى للمقارنة.
References used
Pack AM, Morrell Mj . Epilepsy and bone health in adults Epilepsy Behav 2004
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two most common endocrine disorders in clinical practice. The unrecognized TD may
adversely affect the metabolic control and add more risk to an already predisposing
s
cenario for cardiovascular diseases. The objective of this study was to investigate the
prevalence of TD in patients with type2 diabetes mellitus.
Objective: To determine the prevalence and patterns of thyroid dysfunction in
patients with type2 diabetes mellitus.
Material and methods: Study included total 362 subjects (204 type2 diabetic patients
and 158 healthy non diabetic subjects). Agroup of type2 diabetic patients and control group
were evaluated for thyroid dysfunction by testing TSH and FT4 when TSH was abnormal.
The correlation of prevalence of thyroid disorder with gender distribution, age distribution,
duration of diabetes, BMI, treatment, fasting plasma glucose (FPG), serum triglyceride and
serum cholesterol was then done in diabetic patients. The observations and interpretations
were recorded and results obtained were statistically analyzed.
Results: The prevalence of thyroid dysfunction among type2 diabetic patients was
found to be 13,2%. In the control group, the prevalence of thyroid dysfunction was 6,3%.
There was a significant difference between diabetics and control subjects p= 0,031.The
most frequently TD in type2 diabetic patients was subclinical hypothyroidism (8,3%).
Thyroid dysfunction was significantly correlated with gender (women > man), age < 60
years, FPG > 130mg/dl, TG > 150mg/dl and insulin treatment in type2 diabetic patients.
Conclusion: Screening of thyroid dysfunction shoud be done in all Type2 diabetic
patients.
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