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Register a new userInvestigation of onychomycosis prevalence in patients with psoriasis
دراسة انتشار فطور الأظفار لدى مرضى الصّداف
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تمّ إشراك 113 مريض في الدّراسة. تمّ اختيار المرضى من قسم الأمراض الجلديّة والزّهريّة في مشفى الأسد الجامعي في اللاذقيّة بين عاميّ 2012-2013. تمّ إجراء التحري الفطريّ لجميع المرضى الذّين أظهروا تغيّرات صدافيّة في الأظفار. وتهدف الدراسة إلى تقييم : معدّل حدوث التّغيّرات الظّفريّة لدى مرضى الصّداف، ومعدّل حدوث الفطار الظّفريّ لدى المرضى المصابين بصداف الأظفار، والعوامل الّتي يمكن أن تلعب دور في حدوث الفطار الظّفريّ لدى مرضى صداف الأظفار. وجدنا تغيّرات ظفريّة لدى 61.9% من مرضى الصّداف(70 مريض) . كان الزّرع الفطريّ إيجابيّ لدى 34 مريض (48.6%). كان هناك زيادة في حدوث الفطار الظّفريّ لدى المرضى الّذين أظهروا مستويات مرتفعة لمقياس NAPSI ومدّة طويلة للإصابة بالصّداف والإصابة الصّدافيّة للأظفار. كان هناك علاقة بين الفطار الظّفريّ وعمر المريض. وجدنا ارتفاع في حدوث الفطار الظّفريّ لدى المرضى الّذين يتلقون معالجة جهازيّة مضادّة للصّداف (ميتوتريكسات ، سيكلوسبورين) . ولدى المرضى الّذين لديهم قصّة رضّ على الأظفار. لم تكن هناك علاقة بين الفطار الظّفريّ وجنس المريض. أكّدت الدراسة أنّ الفطار الظّفريّ قد يصيب مرضى صداف الأظفار.
113 psoriatic patients participated in the study. The patients were selected from the Dermatology and Venereology department at Alasad hospital in Lattakia city between 2012-2013 years. Mycological examination was carried out in all patients showing psoriatic nail changes .The aim of the study is to evaluate : the frequency of nail changes in psoriatic patients, the frequency of onychomychosis in patients with nail psoriasis and the factors that may have a role in the incidence of onychomcosis in patients with nail psoriasis. Nail changes were seen in (61.9%) of psoriatic patients (70 patients). Positive mycological cultures were obtained from 34 patients (48.6%). There was an increase of the incidence of onychomycosis in patients with high levels of NAPSI and long duration of psoriasis and nail psoriasis. There was a relationship between onychomycosis and the age of the patient. We found an increase of the incidence of onychomycosis among the patients who had a systemic therapy for psoriasis (methotrexate,cyclosporine) and the patients who had a history of contusion on nails. There was no relationship between onychomychosis and the gender of the patient. This study confirmed that onychomycosis may occur in patients with nail psoriasis
Artificial intelligence review:
Research summary
تهدف هذه الدراسة إلى تقييم معدل انتشار فطور الأظفار لدى مرضى الصداف، وتحديد العوامل التي قد تؤثر على حدوث الفطار الظفري. تم اختيار 113 مريضًا من قسم الأمراض الجلدية والزهرية في مشفى الأسد الجامعي في اللاذقية بين عامي 2012-2013. أظهرت النتائج أن 61.9% من مرضى الصداف يعانون من تغيرات في الأظفار، وأن 48.6% من هؤلاء المرضى لديهم فطار ظفري. كما وجدت الدراسة علاقة بين الفطار الظفري وارتفاع مستويات NAPSI، وطول مدة الإصابة بالصداف، والإصابة الصدافية للأظفار، وعمر المريض، وتلقي المعالجة الجهازية المضادة للصداف، ووجود قصة رضّ على الأظفار. لم تجد الدراسة علاقة ذات دلالة إحصائية بين الفطار الظفري وجنس المريض. وأكدت الدراسة أن الفطار الظفري قد يصيب مرضى صداف الأظفار.
Critical review
تعتبر هذه الدراسة مفيدة في تسليط الضوء على مشكلة الفطار الظفري لدى مرضى الصداف، وتحديد العوامل التي قد تزيد من احتمالية الإصابة. ومع ذلك، يمكن توجيه بعض النقد البناء للدراسة. أولاً، كان من الأفضل توسيع حجم العينة لتشمل عددًا أكبر من المرضى للحصول على نتائج أكثر دقة. ثانيًا، لم تتناول الدراسة تأثير العوامل البيئية بشكل كافٍ، وهو ما يمكن أن يكون له تأثير كبير على نتائج الفحص الفطري. ثالثًا، كان من الممكن تحسين منهجية الدراسة من خلال تضمين مجموعة ضابطة من المرضى غير المصابين بالصداف للمقارنة. وأخيرًا، كان من الأفضل توفير تفاصيل أكثر حول أنواع الفطريات المكتشفة وتأثيراتها المختلفة على الأظفار.
Questions related to the research
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ما هو الهدف الرئيسي من هذه الدراسة؟
الهدف الرئيسي هو تقييم معدل انتشار فطور الأظفار لدى مرضى الصداف وتحديد العوامل التي قد تؤثر على حدوث الفطار الظفري.
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ما هي نسبة مرضى الصداف الذين يعانون من تغيرات في الأظفار؟
61.9% من مرضى الصداف يعانون من تغيرات في الأظفار.
-
هل هناك علاقة بين الفطار الظفري وجنس المريض؟
لا، لم تجد الدراسة علاقة ذات دلالة إحصائية بين الفطار الظفري وجنس المريض.
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ما هي العوامل التي تزيد من احتمالية الإصابة بالفطار الظفري لدى مرضى الصداف؟
العوامل تشمل ارتفاع مستويات NAPSI، طول مدة الإصابة بالصداف، الإصابة الصدافية للأظفار، عمر المريض، تلقي المعالجة الجهازية المضادة للصداف، ووجود قصة رضّ على الأظفار.
References used
BURNS, T ; BREATHNACH, S; COX, N; GRIFFITH, C . Psoriasis . Rook's Textbook of dermatology. Seventh Editio, Blackwell science,2004, pages: 1710-1778
JOHN, Y. M. KOO; LEBWOHL,M.G; LEE,C.S. Psoriasis of the nails, Mild-to- Moderate Psoriasis. Informa Healthcare USA,2006,pages:221-236
WOLFF,K; GOLDSMITH,L.A; KATZ,S.I;GILCHREST,B.A;PALLER,A.S; LEFFELL,D.J. Psoriasis, Fitzpatrick's Dermatology in General Medicine.7th ed, Mc Graw-Hill Medical 2008, pages: 169-193,1817-1818
BOLONGIA,L. J; JORIZZO,L. J; RAPINI,P. R; CALLEN,P. J; HORN,D. T; SALASCHE,J. S; SCHWARZ, T; SEABURY STONE, M. Papulosquamous Dermatoses, Psoriasis, Dermatology, 2nd ed, Mosby Elsevier 2008, pages: 115-135
BARAN,R; DAWBER,R.PR; HANEKE,E; TOSTE,A; BRISTOW,I; THOMAS,L; DRAPÉ,J. Onychomycosis and its treatment, A Text Atlas of Nail Disorders Techniques in Investigation and Diagnosis. Third edition, Martin Dunitz,2003,pages:197-219
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