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Register a new userInvestigation of onychomycosis prevalence in patients with psoriasis
دراسة انتشار فطور الأظفار لدى مرضى الصّداف
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تمّ إشراك 113 مريض في الدّراسة. تمّ اختيار المرضى من قسم الأمراض الجلديّة والزّهريّة في مشفى الأسد الجامعي في اللاذقيّة بين عاميّ 2012-2013. تمّ إجراء التحري الفطريّ لجميع المرضى الذّين أظهروا تغيّرات صدافيّة في الأظفار. وتهدف الدراسة إلى تقييم : معدّل حدوث التّغيّرات الظّفريّة لدى مرضى الصّداف، ومعدّل حدوث الفطار الظّفريّ لدى المرضى المصابين بصداف الأظفار، والعوامل الّتي يمكن أن تلعب دور في حدوث الفطار الظّفريّ لدى مرضى صداف الأظفار. وجدنا تغيّرات ظفريّة لدى 61.9% من مرضى الصّداف(70 مريض) . كان الزّرع الفطريّ إيجابيّ لدى 34 مريض (48.6%). كان هناك زيادة في حدوث الفطار الظّفريّ لدى المرضى الّذين أظهروا مستويات مرتفعة لمقياس NAPSI ومدّة طويلة للإصابة بالصّداف والإصابة الصّدافيّة للأظفار. كان هناك علاقة بين الفطار الظّفريّ وعمر المريض. وجدنا ارتفاع في حدوث الفطار الظّفريّ لدى المرضى الّذين يتلقون معالجة جهازيّة مضادّة للصّداف (ميتوتريكسات ، سيكلوسبورين) . ولدى المرضى الّذين لديهم قصّة رضّ على الأظفار. لم تكن هناك علاقة بين الفطار الظّفريّ وجنس المريض. أكّدت الدراسة أنّ الفطار الظّفريّ قد يصيب مرضى صداف الأظفار.
113 psoriatic patients participated in the study. The patients were selected from the Dermatology and Venereology department at Alasad hospital in Lattakia city between 2012-2013 years. Mycological examination was carried out in all patients showing psoriatic nail changes .The aim of the study is to evaluate : the frequency of nail changes in psoriatic patients, the frequency of onychomychosis in patients with nail psoriasis and the factors that may have a role in the incidence of onychomcosis in patients with nail psoriasis. Nail changes were seen in (61.9%) of psoriatic patients (70 patients). Positive mycological cultures were obtained from 34 patients (48.6%). There was an increase of the incidence of onychomycosis in patients with high levels of NAPSI and long duration of psoriasis and nail psoriasis. There was a relationship between onychomycosis and the age of the patient. We found an increase of the incidence of onychomycosis among the patients who had a systemic therapy for psoriasis (methotrexate,cyclosporine) and the patients who had a history of contusion on nails. There was no relationship between onychomychosis and the gender of the patient. This study confirmed that onychomycosis may occur in patients with nail psoriasis
References used
BURNS, T ; BREATHNACH, S; COX, N; GRIFFITH, C . Psoriasis . Rook's Textbook of dermatology. Seventh Editio, Blackwell science,2004, pages: 1710-1778
JOHN, Y. M. KOO; LEBWOHL,M.G; LEE,C.S. Psoriasis of the nails, Mild-to- Moderate Psoriasis. Informa Healthcare USA,2006,pages:221-236
WOLFF,K; GOLDSMITH,L.A; KATZ,S.I;GILCHREST,B.A;PALLER,A.S; LEFFELL,D.J. Psoriasis, Fitzpatrick's Dermatology in General Medicine.7th ed, Mc Graw-Hill Medical 2008, pages: 169-193,1817-1818
BOLONGIA,L. J; JORIZZO,L. J; RAPINI,P. R; CALLEN,P. J; HORN,D. T; SALASCHE,J. S; SCHWARZ, T; SEABURY STONE, M. Papulosquamous Dermatoses, Psoriasis, Dermatology, 2nd ed, Mosby Elsevier 2008, pages: 115-135
BARAN,R; DAWBER,R.PR; HANEKE,E; TOSTE,A; BRISTOW,I; THOMAS,L; DRAPÉ,J. Onychomycosis and its treatment, A Text Atlas of Nail Disorders Techniques in Investigation and Diagnosis. Third edition, Martin Dunitz,2003,pages:197-219
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colitis. On histopathologic examination, criteria for lymphocytic colitis (intraepithelial
lymphocyte ≥ 20 per 100 surface epithelial cells, change in surface epithelium,
mononuclear infiltration of the lamina propria) and collagenous colitis (subepithelial
collagen band thickness ≥ 10 μm) were explored.
Results:Microscopic colitis was diagnosed in 33 (39%)patients {22lymphocytic
colitis,11collagenous colitis} . Female/Male: 15/18, mean age at diagnosis of microscopic
colitis : 37 year, range: 20-69, the median duration of diarrhea: 9.5 monthes , the median
number of bowel movements per day:5 times .And the common symptoms are:
abdominal pain and flatulence.
Conclusion :Biopsy of Syrian patients with the diagnosis of chronic watery diarrhea
of unknown etiology and normal colonoscopic findings will reveal microscopic colitis in
approximately 39% of the patients. Lymphocytic colitis is two times more frequent than
collagenous colitis in these patients.
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enetic risk, insulin resistance, sympathetic hyperactivity, and vasoactive substances (i.e., angiotensin II); In patients with acute myocardial infarction (AMI) with ST elevation , the prevalence of antecedent hypertension is 32% and these percentage increases with age and in women
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Materials and Methods: The orthodontic records of 623 patients ag
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prevalence of patients with one or more permanent missing teeth.
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common missing tooth was maxillary first molar (0.87%). Missing in the maxillary jaw
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