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Study of risk factors in patients with lacunar infarcts

دراسة عوامل الخطورة عند مرضى الاحتشاءات الفجوية

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 Publication date 2018
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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Purpose: Lacunar infarcts is an important stroke subgroup with unique clinical and pathologic features, but risk factors for lacunar infarcts have been rarely documented. To address this matter, we studied 65 patients had lacunar infarction at Department of Neurology , Tishreen University Hospital , Lattakia , Syria , and 65 controls during the period between May 2017 – May 2018 . Methods: We obtained information concerning risk factor exposure status among the patients by a structured questionnaire , we recorded age , sex , blood pressure , glucose , heart diseases , cigarette smoking , alcohol drinking , physical exercise for patiens and controls .We do laboratory tests and ECG and echocardiography and CT brain or MRI . Results: Significantly increasing the risk of lacunar stroke were hypertension (P-value=0.0001) and (OR=9.9), Current smokers (P-value=0.002) and (OR=5.2), diabetes (P-value=0.001) and (OR=5.3) , whereas frequent physical exercise was associated with a significantly decreased risk) P-value=00001( and (OR=2.6). There was no risk of lacunar stroke associated with heart disease (P-value=0.6) (OR=0.8) , high cholesterol (Pvalue= 1) and (OR=1) , alcohol drinking (P-value=0.7) and (OR=0.8). Conclusions: Patients with hypertension or diabetes, current smokers, those who have not heart disease, are at a higher risk of lacunar stroke, whereas those who undertake regular physical exercise may be at lower risk.


Artificial intelligence review:
Research summary
تهدف الدراسة إلى تحديد عوامل الخطورة المرتبطة بالاحتشاءات الفجوية، وهو نوع من السكتات الدماغية التي تتميز بخصائص سريرية وإمراضية فريدة. شملت الدراسة 65 مريضًا يعانون من احتشاءات فجوية و65 شاهدًا في الفترة من مايو 2017 إلى مايو 2018 في قسم الأمراض العصبية بمشفى تشرين الجامعي في اللاذقية. تم جمع البيانات باستخدام استبيان منظم وتسجيل معلومات مثل العمر، الجنس، ضغط الدم، مستوى السكر، وجود أمراض قلبية، التدخين، تناول الكحول، وممارسة التمارين الرياضية. أظهرت النتائج أن ارتفاع ضغط الدم (P-value=0.0001) والتدخين (P-value=0.002) والسكري (P-value=0.001) تزيد من خطر الاحتشاءات الفجوية، بينما تقلل ممارسة التمارين الرياضية من هذا الخطر (P-value=0.002). لم يكن هناك ارتباط بين الاحتشاءات الفجوية وأمراض القلب (P-value=0.6)، ارتفاع الكولسترول (P-value=1)، أو تناول الكحول (P-value=0.7). خلصت الدراسة إلى أن المرضى الذين يعانون من ارتفاع ضغط الدم أو السكري أو المدخنين هم أكثر عرضة للاحتشاءات الفجوية، بينما الذين يمارسون التمارين الرياضية بانتظام هم أقل عرضة للإصابة.
Critical review
دراسة نقدية: تعتبر هذه الدراسة مهمة لفهم عوامل الخطورة المرتبطة بالاحتشاءات الفجوية، ولكن هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة المدروسة كان صغيرًا نسبيًا، مما قد يؤثر على القوة الإحصائية للنتائج. ثانياً، لم يتم إجراء تصوير للدماغ للشواهد، مما قد يؤثر على دقة المقارنة بين المرضى والشواهد. ثالثاً، الدراسة لم تأخذ في الاعتبار بعض العوامل الأخرى التي قد تؤثر على النتائج مثل النظام الغذائي ومستوى النشاط البدني اليومي. على الرغم من هذه النقاط، فإن الدراسة تسلط الضوء على أهمية التحكم في ضغط الدم ومستوى السكر والإقلاع عن التدخين كوسائل للحد من خطر الاحتشاءات الفجوية.
Questions related to the research
  1. ما هي عوامل الخطورة الرئيسية للاحتشاءات الفجوية التي تم تحديدها في الدراسة؟

    عوامل الخطورة الرئيسية التي تم تحديدها هي ارتفاع ضغط الدم، التدخين، والسكري.

  2. هل هناك علاقة بين ممارسة التمارين الرياضية وخطر الاحتشاءات الفجوية؟

    نعم، أظهرت الدراسة أن ممارسة التمارين الرياضية بانتظام تقلل من خطر الاحتشاءات الفجوية.

  3. هل هناك ارتباط بين أمراض القلب وخطر الاحتشاءات الفجوية؟

    لا، لم تجد الدراسة ارتباطًا هامًا بين أمراض القلب وخطر الاحتشاءات الفجوية.

  4. ما هي التوصيات التي قدمتها الدراسة للحد من خطر الاحتشاءات الفجوية؟

    التوصيات تشمل التحكم الجيد في ضغط الدم ومستوى السكر، الإقلاع عن التدخين، وممارسة التمارين الرياضية بانتظام.


References used
MART-VILALTA JL, ARBOIX A, MOHR JP. Lacunes. In: Stroke. Pathophysiology, Diagnosis, and Management. Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PhA (Eds). Churchill–Livingstone, PA, USA, 2004, 275–299
FISHER CM. Lacunar strokes and infarcts: a review. Neurology 32(8): 1982; 871-6
FISHER CM. Lacunes: Small, Deep Cerebral Infarcts. Neurology 15: 1965; 774-84
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