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Gastrointestinal stromal tumors (GISTs) Risk factors and surgical treatment

أورام اللحمة في القناة المعدية المعوية عوامل الخطورة و التدبير الجراحي

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 Publication date 2015
and research's language is العربية
 Created by Shamra Editor




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A retrospective study of 55 cases (mean age 55, range 82 ـ 35 years) of Gastrointestinal stromal tumors cancer admitted at AL Assad University Hospital , Lattakia , Syria. from 1\1\2002 to 1\1\2014 for studying its :locations ,risk factors and surgical management. Stomach was the most common site for GISTs in 52.27% , small intestinal in 30.90%, rectum in 9.09% and colon in 7.27%. The most common clinical signs and symptoms were: gastrointestinal bleeding 61.8% ,abdominal pain 21.81%.the histologic prognosis was high and moderate in 72.72% of patients. Total gastrictomy was performed for one patient ,subtotal gastrictomy for 16 patients and a wedge in 11 cases. In 6 patients a segementectomy of small intestinal were performed. and in one patient a resection of the upper rectum performed.


Artificial intelligence review:
Research summary
تتناول هذه الدراسة الاسترجاعية أورام اللحمة في القناة المعدية المعوية، حيث شملت 55 مريضًا ومريضة تتراوح أعمارهم بين 35 و82 سنة، بمتوسط عمر 58.5 سنة. أجريت الدراسة في مشفى الأسد الجامعي باللاذقية في الفترة من 2002 إلى 2014. كانت المعدة هي الموقع الأكثر شيوعًا للإصابة بنسبة 52.27%، تليها الأمعاء الدقيقة بنسبة 30.90%، ثم المستقيم بنسبة 9.09%، وأخيرًا الكولون بنسبة 7.27%. كانت الأعراض الأكثر شيوعًا هي النزف الهضمي بنسبة 61.8%، والألم البطني بنسبة 21.81%. تم تصنيف الإنذار النسيجي لمعظم المرضى (72.72%) على أنه متوسط وعالٍ. تم إجراء استئصال المعدة التام في حالة واحدة، واستئصال المعدة تحت التام في 16 حالة، واستئصال نصف المعدة القاصي في حالة واحدة، واستئصال منطقة الورم مع هامش أمان (wedge) في 11 حالة. بالنسبة للأورام في الأمعاء الدقيقة، تم استئصال العروة المعوية المحتوية على الورم، وفي حالة المستقيم تم استئصال منطقة الورم وإجراء المفاغرة يدويًا. خلصت الدراسة إلى أن الجراحة الاستئصالية هي المقاربة الأفضل للأورام القابلة للاستئصال مع هامش أمان كافٍ، وأوصت بتجنب تجريف العقد اللمفاوية إلا في حالات خاصة.
Critical review
دراسة نقدية: تعتبر هذه الدراسة مهمة لأنها تسلط الضوء على أورام نادرة الحدوث وتقدم بيانات قيمة حول توزيعها وعوامل الخطورة المرتبطة بها. ومع ذلك، يمكن توجيه بعض الانتقادات البناءة لتحسين الدراسة. أولاً، كان من الأفضل تضمين مجموعة مقارنة من المرضى الذين يعانون من أنواع أخرى من الأورام الهضمية لتقديم سياق أوسع للنتائج. ثانيًا، لم تتناول الدراسة بشكل كافٍ العلاجات غير الجراحية الممكنة مثل العلاج الكيميائي أو الإشعاعي، والتي قد تكون ذات أهمية لبعض المرضى. ثالثًا، كان من الممكن تحسين الدراسة بإجراء متابعة طويلة الأمد للمرضى لتقييم النتائج على المدى البعيد. وأخيرًا، كان من المفيد تضمين تحليل إحصائي أكثر تفصيلاً لتحديد العوامل التي تؤثر بشكل كبير على نتائج العلاج.
Questions related to the research
  1. ما هو الموقع الأكثر شيوعًا للإصابة بأورام اللحمة في القناة المعدية المعوية؟

    المعدة هي الموقع الأكثر شيوعًا للإصابة بأورام اللحمة بنسبة 52.27%.

  2. ما هي الأعراض الأكثر شيوعًا لدى المرضى المصابين بأورام اللحمة؟

    الأعراض الأكثر شيوعًا هي النزف الهضمي بنسبة 61.8% والألم البطني بنسبة 21.81%.

  3. ما هو الإجراء الجراحي الأكثر شيوعًا لعلاج أورام اللحمة في المعدة؟

    الإجراء الجراحي الأكثر شيوعًا هو استئصال المعدة تحت التام، والذي تم إجراؤه في 16 حالة.

  4. ما هي التوصيات الرئيسية التي قدمتها الدراسة بشأن علاج أورام اللحمة؟

    أوصت الدراسة بالجراحة الاستئصالية لكامل الورم مع هامش أمان كافٍ، وتجنب تجريف العقد اللمفاوية إلا في حالات خاصة، واستخدام الجراحة التنظيرية في بعض الحالات.


References used
BONVALOT S ,CAVALCANTI A.Chirurgie des GIST . Gastroenteral Clin Biol. France vol 28 , 2004 A 103
BALATON AJ,C JM,CVITKOVIC F. Tumeurs stromale digestives Gastroenteral Clin Biol .France 2001,25:473 82
JOENSUU H, FLETCHER C, DIMITRIJEVIC S, et al. Management of malignant gastrointestinal stromal tumours. Lancet Oncol 2002,3:655-664
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