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Register a new userThe Role of Platelets indices (Mean Platelet Volume MPV , Platelet Distribution Width PDW)in the diagnosis of Thrombocytopenia
دور مناسب الصفيحات (حجم الصفيحات الوسطي و معدل توزع الصفيحات) في التشخيص السببي لنقص الصفيحات
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Tishreen University ورقة بحثية
Publication date
2018
fields
Medicine
and research's language is
العربية
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Shamra Editor
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مقدمة: يعد نقص الصفيحات من أشيع الاضطرابات الدموية المشاهدة عند مرضى العيادات و المقبولين ضمن المشفى، و تتراوح أعراضها السريرية من الحالات اللاعرضية إلى النزوف الخطيرة المهددة للحياة. يعتمد تشخيص سبب نقص الصفيحات بشكل أساسي على دراسة نقي العظم و هو إجراء راض. تعداد الدم الكامل يجرى حالياً بشكل روتيني و دون كلفة بالاعتماد على أجهزة التحليل الآلي و تظهر هذه الأجهزة مناسب الصفيحات و لازال استخدامها محدوداً في مقاربة نقص الصفيحات. الهدف: تحري وجود علاقة بين مناسب الصفيحات (حجم الصفيحات الوسطي MPV و معدل توزع الصفيحات PDW) و سبب نقص الصفيحات (مركزي المنشاً على مستوى نقي العظم أو محيطي خارج النقي) و تحديد الحساسية و النوعية لهذه المناسب لبحث إمكانية استخدامها في المقاربة البدئية لنقص الصفيحات.
Introduction: Thrombocytopenia is considered to be a common complain of outpatients and hospitalized ones, ranging from asymptomatic to severe death causing hemorrhage. Diagnosing thrombocytopenia depends mainly on study of bone marrow which is an invasive process. Complete Blood Count on automated hematology analyzers is widely used nowadays with no extra cost, and platelets indices are part of the blood profile and less often used in diagnosing thrombocytopenia. Aim of the study: Investigation of a possible relationship between platelets indices (MPV and PDW) and thrombocytopenia etiologies (hypoproductive or hyperdestructive), and determine the sensitivity and specificity of platelets indices in the approach of thrombocytopenia.
References used
WESSELS P, HEYNS AD, PIETERS H, et al. An improved method for the quantification of the in vivo kinetics of a representative population of 111In-labelled human platelets. Eur J Nucl Med 2008; 10:522
HARKER LA, FINCH CA. Thrombokinetics in man. J Clin Invest 2010; 48:963
ZAULI G, VITALE M, FALCIERI E, et al. In vitro senescence and apoptotic cell death of human megakaryocytes. Blood 1997; 90:2234
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Platelets play a key role in the development and progression of atherosclerosis.
Platelet volume is an indicator of platelet activation and function, and it can be assessed by
platelet volume indices (PVI) such as mean platelet volume (MPV), platel
et distribution
width (PDW), and Platelet-large cell ratio (P-LCR). PVI are potentially useful markers for
the prediction of acute coronary syndromes. Thus our study aims to evaluate the
relationship between them and clinical features of coronary artery disease (CAD).
Our population is represented by 60 patients undergoing coronary angiography at Al-
Assad University Hospital, Lattakia, Syria. Patients were evenly divided into four groups
according to their clinical presentation; control group, stable angina group, unstable angina
group, and acute myocardial infarction (MI) group. PVI were measured in all patients.
We found a significant increase in MPV (P=0.04), PDW (P=0.03), and P-LCR
(P=0.03) in patients compared to healthy control subjects. We calculated the cutoff points
of these indices to help diagnosing the progressive atherosclerotic plague, P-LCR>28.7%
(P=0.01) [sensitivity 44%, specificity 93%], and diagnosing MI, PDW>13.8 (P=0.01)
[53%, 100%], MPV>10.4 (P=0.004) [60%, 93%], P-LCR>28.7 (P=0.003) [66%, 93%].
In conclusion, PVI are simple and easy methods that can be used as a predictive
marker in CAD patients.
Cancer is an important global health issue, and colorectal cancer is one of the most common cancers worldwide. It was recently discovered that the systemic inflammatory response plays a supportive role in various types of cancer, including colorectal
cancer. The inflammatory response can be reflected by several indexes, including the platelet lymphocyte ratio (PLR).Cancer is an important global health problem, and colorectal cancer is one of the most common cancers. In contrast, the systemic inflammatory response has a warning role in many types of cancer, including colorectal cancer. The inflammatory response can be evaluated with several indicators, including the platelet lymphocyte ratio PLR. Lymphocyte Ratio PLR)) Can't load full results Try again Retrying... Retrying... Our study aimed to evaluate the relation between platelet lymphocyte ratio and to correlate this ratio with the clinicopathological characteristics of non-metastatic colorectal cancer patients. We enrolled 95 non-metastatic colorectal patients at Oncology Depatment at Tishreen University Hospital. Our results revealed that there were statistically significant differences in the higher mean of lymphocyte platelets ratio by the stage of the tumor (p<0.0001), by the size of the tumor (p=0.001), and by the metastases of the lymph nodes (p=0.03), as the mean increases with the tumor stage with the size of the tumor and the formation of metastases in the lymph nodes. While there were no statistically significant differences in the higher mean of lymphocyte platelets by the histological grade of tumor (p = 0.1), as well as by the tumor location in the left and right colon (p= 0.3). These results reflect the correlation of the high percentage of lymphocyte platelets with the histopathological clinical characteristics that indicate a poor prognosis in patients with colorectal cancer
إن أهمية الوسائل غير الغازية تكمن في التقليل من الاعتماد على إجراء تنظير هضمي علوي و خاصة عند مرضى الذين احتمالية تواجد دوالي مري عندهم قليلة
كما تكمن أهميتها بسبب عدم توفر أجهزة تنظير في بعض المناطق .
يمكننا الاعتماد على نسبة تعداد الصفيحات على
قطر الطحال كمشعر على وجود دوالي مري أو عدم وجودها .
Introduction: Urinary tract infections are very common in childhood (especially under the age of 5 years) and because of the large number of complications resulting from it (renal failure – hypertension- kidney scarring) had to be diagnosed and early
treatment, although that urine culture is the standard Golden diagnosis, but its results are late to appear, Many studies have indicated an accompanying increase in platelet counts in urinary tract infections, so that platelet counts may be a vital indicator directed to it without asylum to the costly analyzes in its diagnosis. Objective: the objective of the following study is to assess the sensitivity and specificity of the plate count (PLT) in UTI. Methods: The study included 65 Patients (14 males, 51females) They were between (3-6) year with upper urine tract infections were diagnosed through symptoms, urological test, Serum tests, and radiology, who were admitted to the pediatric department at Tishreen University Hospital in Lattakia City. PLT was obtained through a complete CBC blood count (sensitivity and sensitization), and comparison of the ratio Percentage of Thrombocytosis between urine culture with Gram-positive germs and Gram-negative germs. Results: The study showed a good sensitivity=80.39% [75–84] to platelet counts compared to urine culture. it also showed statistically significant paper p-value=0.003 between platelet count and type of pathogen (positive or negative Gram) and the increase was more favorable to positive urine culture. Also showed that the average value of platelets is higher in culture a positive gram 521.9±90.9 x103 platelet/mcl than in gram negative 432.3±73.5 x103 platelet/mcl. Conclusion: higher Platelet numbers are a good analysis or sensitivity for the diagnosis of upper urinary tract infection in children with reliable urinary symptoms to start treatment. So that we get the results of culture urine .and the higher platelet count must be taken gram positive bacteria into account.
The aim of this study is to evaluate the clinical outcomes (pain P ,
joint sounds JS , and diversion in the mandibular movement DMM)
of treatment of anterior displacement of articular disc via injection of
PRP. The sample consisted of 40 patients
who referred to the faculty
of dentistry with unilateral anterior displacement of articular disc
with pain P , joint sounds JS , and diversion in the mandibular
movement DMM.
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