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Register a new userImmunofluorescence Expression of PCNA Marker in Melanic Tumors of Compared With CD31 Marker
التعبير المناعي للواسم PCNA في الأورام الميلانينية عند الكلاب بالمقارنة مع الواسم CD31
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المجلة السورية للبحوث الزراعية ورقة بحثية
Publication date
2018
fields
Genetics
and research's language is
العربية
Authors
رواد يوسف موسى( باحث )
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يتمّ تصنيع PCNA في نواة الخلية في المرحلة G1.S من دورة الانقسام الخلوي، و هذا الأمر يساعد في تقدير عدد الخلايا المنقسمة، و التحذير في حال وجود ورم. أمّا CD31 فيوسم خلايا الأوعية الدموية الجديدة التي يشكّلها الورم، و هذه الأوعية تساعد على تقدير درجة خباثة الورم. الهدف من الدّراسة هو تحليل الصور المأخوذة للمقاطع النسيجية الموسومة بواسطة (CD31 و PCNA) باستخدام الحاسوب، و ذلك لقياس شدّة تلوّن الخلايا الورميّة بواسطة (PCNA) و الأوعية بواسطة (CD31)، من أجل دراسة علاقة هذه الواسمات مع درجة خباثة الورم، و ذلك من خلال مقارنتها مع الواسمات المجهرية الأخرى. تمّ تشخيص 12 حالة ورمية ميلانينية عند الكلاب في كلية الطب البيطري، قسم التشريح المرضي، كلوج، نابوكة في الفترة 2001- 2010 م.
PCNA is synthesized in early G1 and S-phases of cell cycle. Tight linkage to cell proliferation has led to the investigation of its role in the evaluation of tumors for prognosis. The aim of this study is to use computerized image analysis to measure PCNA and CD31 antibodies in a series of canine melanocytic tumors to assess density of marked cells by these antibodies, and to correlate density of marked cells with malignant degree of these tumors through comparative study between CD31, PCNA and microscopic aspect. 12 dog melanic tumors were diagnosed during the period 2001–2010 in Pathology Department USAMV Cluj-Napoca, for PCNA expression study, and 10 samples of them were treated with CD31 marker by immunohistochemical for comparative study.
References used
AKE, D.; H.B. Hellquisti; K. villman; and G. Westman (1993). Malignant melanoma of the ear. The Journal of Laryngology and Otology. 107: 798-802
Bussanich, N.M.; P.J. Dolman; J. Rootman; and C.L. Dolman (1987). Canine uveal melanomas: series and literature review. J. Am. Anim. Hosp. Assoc., 23:415–422
Clark, J.R., W.H. Elder; and D.E. Guerry (1989). Model predicting survival in stage I melanoma based on tumor progression. J. Natl. Cancer Inst., 81: 1893
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