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Register a new userAssessment of Procalcitonin as an Early Diagnostic and Prognostic Marker of Sepsis in Cancer Patients
البروكالسيتونين كعلامة تنبؤية و تشخيصية مبكرة للإنتان عند مرضى السرطان
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Tishreen University ورقة بحثية
Publication date
2016
fields
Medicine
and research's language is
العربية
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أجريت الدراسة لتقييم كفاءة البروكالسيتونين في تشخيص الإنتان الجرثومي عند مرضى السرطان في مركز المعالجة الكيماوية و الشعاعية في مشفى تشرين الجامعي باللاذقية في الفترة الواقعة بين 3\1\2015 إلى 28\3\2016. شملت الدراسة (45) مريضاً كان منهم (25) مريض انتان مثبت و (20) مريض انتان غير مثبت، و جميعهم لديهم حمى و غير متناولين للصادات الحيوية حيث خضع المرضى لتقييم بدئي شامل تضمن فحص سريري دقيق و فحوص مخبرية عديدة و صور شعاعية كما تم قياس البروكالسيتونين أثناء الترفع الحروري و مقارنته مع البروتين المتفاعل C، و أشارت النتائج الى وجود ارتباط هام بين البروكالسيتونين و الانتان حيث كانت القيم الوسطية للبروكالسيتونين عند مرضى الانتان المثبت 16.9 نغ/مل مقابل 0.7 نغ/مل عند مرضى الانتان غير المثبت، كما ترافق ازدياد تركيز البروكالسيتونين مع زيادة شدة الانتان، و اظهرت الدراسة أن البروكالسيتونين أكثر حساسية و نوعية من ال CRP في تشخيص وجود انتان عند مرضى السرطان.
The study is carried out to estimate the efficiency of Procalcitonin in the diagnosis of bacterial infection in cancer patients at Chemical and Radiation Therapy Center in Tishreen University Hospital in Lattakia between 3/1/2015-28\3\2016. This study has included 45 patients, 25 with infection and 20 without infection, all of them have a fever and don't take antibiotics. The all of patients has undergone a comprehensive initial assessment included history, physical examination, biochemical parameters and X-ray images. Procalcitonin was also measured during fever and compared with C-reactive protein CRP, the results indicated that there is a significant correlation between Procalcitonin and infection, where the median values Procalcitonin in patients with infection 16.9 ng/ml compared to 0.7 ng/ml in patients without infection, Procalcitonin concentration was also associated with the severity of the infection, the study showed that the Procalcitonin is more sensitive and specific of the CRP in diagnosing of sepsis in cancer patients.
References used
LE MOULLEC J.M, JULLIENNE A, CHENAIS J, LASMOLES F, GULIANA J.M, MILHAUD G, et al. The complete sequence of human preprocalcitonin. FEBS 1984, 167: 93-97
NYLEN E.S, SNIDER R.H, THOMPSON K.A., ROHATGI P, BECKER K.L. Pneumonitis-associated hyperprocalcitoninemia. Am J Med Sci 1996, 312: 12-18
LINSCHEID P, SEBOEK D, NYLEN E.S, LANGER I., SCHLATTER M, KELLER U, BECKER K.L. and MÜLLER B. In vitro and in vivo calcitonin-I gene expression in parenchymal cells: a novel product of human adipose tissue. Endocrinol 2003,144, 5578-5584
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Background: cancer patients experience large physical and emotional challenges
related to side effects of chemotherapy drugs, which make coping and adaptation essential
issue for coping with disease. Aim: this study was conducted to identify coping
strategies
among cancer patients during chemotherapy and its relation with patient's age and gender
Methods: data were collected from 150 patients from Tishreen university hospital by using
brief coping questionnaire in addition to demographical sheet Results : the results
revealed that cancer patients tend to use various coping strategies which are problemfocused
and emotional- focused, reflected positive and negative coping. The most used
coping strategies were active coping strategy (78.66%), followed by seeking social support
for instrumental reasons strategy (76.66%), followed by planning strategy (76%), then
focus on and venting of emotions (75.33%), followed by acceptance strategy (70.66%),
then seeking social support for emotional reasons (68%), then turning to religion (58%).
Also results showed that coping strategies changed according to age and gender changing
(p < 0.05) where women tend to use emotional- focused coping strategies while aged
patients prefer emotional social support and acceptance. Conclusion: emotional issues for
cancer patients during chemotherapy require more concern with ongoing assessment for
adaptation and coping strategies, for designing appropriate interventions agreed with
coping behaviors which cancer patients demonstrate during treatment.
Fatigue is one ofthemostimportant and common side effectamong cancer patient
under chemotherapy. Objective:the study aimed is to study the effect back, hand and foot
massage on fatigue levelto cancer patient under chemotherapy.Material and method:t
he
study was conducted of (75) patients were adult male divided on five groups (back
massage, hand massage, foot massage,[back, hand and foot massage] and control group)
atchemotherapy unit, Tishreen University Hospital, and all of them are under
chemotherapy. Data collected by the personal information form, the fatigue severity scale
was used.Results:This study showed that back, hand and foot massage together was the
most effective in reduce fatigue levels and recommended about importance of massage for
patients under chemotherapy.
Oral complications are common in patients with cancer who
undergo chemotherapy treatment. Not all patients are at equal risk
for developing oral complications. A number of variables have been
identified that bear on both the frequency and severity
of oral
problems associated with therapy. These can be divided into those
that are associated with the patient and those that are related to the
treatment regimen. In this study we have studied the effect of
patient age and gender on the oral complications in group of patients
who undergo chemotherapy treatment. We conclude that aging can
affect some oral complication chemotherapy like xerostomia and
taste changes whereas gender has it effect on pain and oral sence
disorders mainly in males.
Lung cancer is the major cause of cancer death. S100A7
overexpression has been associated with early stages of
carcinomas . This study aimed to evaluate the levels of serum
S100A7 in lung cancer. Our study contains 63 patients of lung
cancer (46
newly diagnosis patients, 11 treated patients, 6
recurrence patients) and 15 healthy volunteers
Cancer alone kills 7.6 million people every year. According to World Health Organization (WHO) estimates, cancer deaths in the Eastern Mediterranean Region will increase from 9.4% in 2015 to 12.3% in 2030 of all deaths. These estimates are based on t
he impact of population growth and aging, as well as increased exposure to factors that increase the incidence of cancer, such as smoking, unhealthy diet, physical inactivity, alcoholism and environmental pollution, which will lead to a higher burden of cancer. Therefore, the current descriptive study was conducted to assess some of the risk factors associated with cancer. This study was applied to a sample of 100 cancer patients available in the Oncology Department at Tishreen University Hospital in Lattakia city. A questionnaire developed by the researcher was used for this purpose. The results showed that there are many risk factors that can be prevented, the most important of which are smoking, eating secreted meals, preserving food in plastic containers, and the presence of communication towers next to places of residence or work. The study recommended the necessity of conducting health education sessions about cancer and predisposing risk factors, activating the role of institutions and organizations in preventing risk factors, and conducting other research at the republic level.
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