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The effect of diabetes mellitus type II on pulmonary function

دراسة تأثير الداء السكري نمط II على وظائف الرئة

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 Publication date 2017
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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Background: Diabetes mellitus is a leading public health problem with increasing incidence and long term complications. These complications are mainly a consequence of macro-vascular and microvascular damages of the target organs. The incidence of several pulmonary abnormalities during the course of Diabetes Mellitus because the presence of an extensive microvascular circulation and abundant connective tissue in the lungs , raises the possibility that lung tissue may be a target organ in diabetic patients. Objectives: This research is designed to study the impact of DM and both the duration of the disease and the glycemic control on pulmonary function tests. Methodology: This is a cross-sectional study carried out on 75 patients with type II diabetes mellitus patients at Tishreen University Hospital in the period between October 2015 and October 2016 .We compared with a control group consisted of 75 non diabetic healthy persons . Measurement of HbA1C , fasting plasma glucose (FPG) , and spirometry were made to all subjects and the following pulmonary function parameters were recorded: Forced Expiratory Volume in the first second (FEV1), Forced Vital Capacity (FVC), and Forced Expiratory Volume percent (FEV1/ FVC%) . Results were analyzed by calculating Mean ± SD, using X2 test , Karl Pearson correlation and ANOVA test. Results: The mean FEV1, FVC, FEV1/FVC% values were low in diabetics (p value <0.05) compared to healthy non-diabetics (control group). Also, uncontrolled diabetics show a greater decrease in these values than controlled diabetics. There was a greater decrease in these values in patients with long period of disease . Conclusion: The findings of the present study suggest that, the lung is a target organ for damage in DM and diabetics show a decrease in PFTs with a restrictive pattern lesion compared with non-diabetics . And this deterioration is exaggerated in uncontrolled diabetics and with the long duration of DM .


Artificial intelligence review:
Research summary
تتناول هذه الدراسة تأثير الداء السكري من النمط الثاني على وظائف الرئة. يُعتبر الداء السكري مشكلة صحية عامة كبرى مع تزايد مستمر في معدل الإصابة والاختلاطات طويلة الأمد، والتي تكون بشكل رئيسي نتيجة للتخرب الوعائي المجهري في الأعضاء الهدفية. تهدف الدراسة إلى تقييم تأثير الداء السكري ومدة الإصابة به وضبط الحالة السكرية على وظائف الرئة. أجريت الدراسة على 75 مريضًا بالداء السكري من النمط الثاني و75 شخصًا سليمًا كمجموعة شاهد. تم قياس الخضاب الغلوكوزي وسكر الدم الصيامي وإجراء اختبار وظائف الرئة (spirometry) لجميع المشاركين. أظهرت النتائج أن مرضى الداء السكري لديهم تراجع في وظائف الرئة مقارنةً بالأصحاء، وأن هذا التراجع يزداد مع طول مدة الإصابة وارتفاع مستويات سكر الدم. تقترح الدراسة أن الرئة هي عضو هدفي لإصابة الداء السكري، وأن ضبط سكر الدم يمكن أن يقلل من تأثيرات الداء السكري على وظائف الرئة.
Critical review
دراسة نقدية: تقدم هذه الدراسة مساهمة هامة في فهم تأثير الداء السكري من النمط الثاني على وظائف الرئة. ومع ذلك، يمكن الإشارة إلى بعض النقاط التي قد تعزز من قوة الدراسة. أولاً، كان من الممكن توسيع حجم العينة لزيادة دقة النتائج. ثانيًا، لم يتم تناول تأثير العوامل البيئية مثل التدخين أو التلوث الهوائي بشكل كافٍ، والتي قد تؤثر أيضًا على وظائف الرئة. ثالثًا، قد يكون من المفيد إجراء دراسات مستقبلية تتناول تأثير الداء السكري على وظائف رئوية أخرى مثل التبادل الغازي وسعة انتشار أول أكسيد الكربون (Dlco). وأخيرًا، قد تكون هناك حاجة لمزيد من الدراسات الطولية لتأكيد النتائج على مدى فترة زمنية أطول.
Questions related to the research
  1. ما هو الهدف الرئيسي من هذه الدراسة؟

    الهدف الرئيسي من الدراسة هو تقييم تأثير الداء السكري من النمط الثاني ومدة الإصابة به وضبط الحالة السكرية على وظائف الرئة.

  2. ما هي الأدوات المستخدمة في قياس وظائف الرئة في هذه الدراسة؟

    تم استخدام اختبار وظائف الرئة (spirometry) لقياس الحجم الزفيري الأقصى في الثانية الأولى (FEV1)، والسعة الحيوية القسرية (FVC)، والنسبة (FEV1/FVC).

  3. ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟

    توصلت الدراسة إلى أن مرضى الداء السكري من النمط الثاني لديهم تراجع في وظائف الرئة مقارنةً بالأصحاء، وأن هذا التراجع يزداد مع طول مدة الإصابة وارتفاع مستويات سكر الدم.

  4. ما هي التوصيات التي قدمتها الدراسة بناءً على النتائج؟

    أوصت الدراسة بإجراء اختبار وظائف الرئة بشكل روتيني لجميع مرضى الداء السكري من النمط الثاني، وضبط مستويات سكر الدم بشكل جيد، وإجراء المزيد من الدراسات المستقبلية حول تأثير الداء السكري على وظائف رئوية أخرى.


References used
World Health Organization. Report of WHO study group. WHO Technical Report Series1985; No 727
WILD S, ROGLIC G, GREEN A. Global prevalence of diabetes. Diabetes Care 2004;27:1047-1053.2
GUYTON AC, HALL JE. Textbook of Medical physiology. 11thEdition. Elsevier Inc, New Delhi.2006
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