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Register a new userControlling Advanced Neck Disease: Efficacy of Neck Dissection and Radiotherapy
السيطرة على الانتقالات العقدية المتقدمة: فعالية تجريف العنق و العلاج الشعاعي
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Tishreen University ورقة بحثية
Publication date
2017
fields
Medicine
and research's language is
العربية
Authors
أريج العساف( باحث )
Created by
Shamra Editor
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الموضوع: يبقى تجريف العنق الطريقة المعتمدة لتدبير الانتقالات العقدية الرقبية من الكارسينوما شائكة الخلايا في أورام الرأس و العنق. تسلط هذه الدراسة الضوء على فعالية تجريف العنق الجذري، و الجذري المعدل المشرك مع العلاج الشعاعي لتدبير الانتقالات العقدية الرقبية N2، N3 في الكارسينوما الشائكة الخلايا في الرأس و العنق. الطرق: تمت الدراسة بصورة راجعة من تموز 2010 إلى حزيران 2014 على 43 عنق مجرّف، عند 39 مريضاً مصاباً بانتقال عقدي رقبي مرحلة ثانية أو ثالثة، عولجوا بشكل مبدئي بتجريف عنق متبوع بعلاج شعاعي. جميع المرضى لديهم كارسينوما شائكة الخلايا في الرأس و العنق. استمرت مدة المتابعة سنتين بعد الجراحة. الخلاصة: إن إشراك تجريف العنق الجذري أو الجذري المعدل مع العلاج الشعاعي فعال بشكل كبير في السيطرة على الانتقال العقدي في حال السيطرة الموضعية على الورم البدئي، مع المحافظة على العصب الشوكي إذا كانت الحالة الورمية تسمح بذلك.
Objective: Neck dissection remains the standard method of treating cervical metastasis from head and neck squamous cell carcinoma. We reviewed our experience with radical and modified RND (MRND) plus radiotherapy as treatment for N2/N3 neck disease in head and neck squamous cell carcinoma. Methods we retrospectively reviewed our clinical records from july 2010 to june 2014 identify 43 neck dissections in 39 patients who were found to have N2 or N3 neck disease treated primarily by neck dissection and postoperative radiotherapy. All patients had head and neck squamous cell carcinoma with a minimum follow up of 24 months. Conclusions the combination of RND or MRND and radiotherapy is effective in controlling neck disease in the absence of persistent or recurrent local disease. MRND supports preservation of the spinal nerve whenever oncologically feasible.
References used
CUMMING, Ch. W. OTOLARYNGOLOGY HEAD & NECK SURGERY.4th ed, mosby, USA, 2005, 2816
STELL & MARAN, J. C. HEAD and NECK SURGERY. 5thed, Butterworth, London, 2013, 520
LORE, J. M. HEAD & NECK SURGERY. 4thed, Elsevier, Pennsylvania, 1988,1491
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Objective: to evaluate the efficacy of the selective neck dissection in the
management of the clinically node-negative neck.
Study Design case histories were evaluated retrospectively.
Methods the results of 75 neck dissections performed on 52 pat
ients were studied.
Results theprimarysites were oral cavity 20, oropharynx 7, hypopharynx 4, and
latynx 21.
14 necks (23%) were node positive on pathological examination. The number of
positive nodes varied from 1 to 9 per side. Of necks with positive 4 (24%) had
extracapsular spread. The median follow up was 24 months. Two recurrences developed
outside the dissected field. The incidence of regional recurrences was similar in patients in
whom nodes were negative on histological examination 3% when compared with patients
with positive nodes without extracapsular spread 4%. In contrast regional recurrence
developed in 18% of necks with extracapsular spread. This observation was statistically
significant. Patients having more than two metastatic lymph nodes had a higher incidence
of recurrent disease than the patients with carcinoma limited to one or two nodes.
Conclusion SND is effective for controlling neck disease and serves to detect
patients who require adjuvant therapy.
Objective : to analyze the level (site) of ipsilateral neck recurrences after
supraomohyoid neck dissection in patients with lip, oral and oropharyngeal cancer treated
in a single institution.
Between 2010 – 2013, 38 patients underwent 38 supraomo
hyoid neck dissection.
Results: there were 5 cases (13%) of ipsilateral neck recurrences, 2 were beyond the
limits of the supraomohyoid neck dissection, and 3 were inside these limits. There was no
association of neck recurrences with pathological status of lymph nodes. 4 of the 5
recurrences were in patients who underwent postoperative radiotherapy.
Objectives: This study aims to evaluate the pattern of nodal metastasis to level V in
parotid cancer and to examine the clinical value of level V neck dissection (LVND).
Study Design: Retrospective study.
Methods: LVND was performed in 10.6% and 2
8.2% of patients with clinical N0
(cN0) and cN+ neck disease, respectively. The prevalence of pathological positive nodal
metastasis was 0% (cN0) and 81.8% (cN+). In patients with cN0 neck, the rate of
recurrence in level V was 6%.
Conclusion: in our patient cohort, LVND was necessary in patients with cN+ neck
because there was a high likelihood for pathologically positive nodal metastasis. In patients
with cN0 neck, the rate of recurrence in level V was low enough not to warrant a routine
inclusion of LVND.
this study Aimes to Investigate CXCR4 expression in primary head
and neck squamous cell carcinomas tumors in all clinical stages and
histological grades, then compare it with control normal oral
epithelial tissues.
Compare metastatic lymph nodes
CXCR4 expression with their
primary HNSCC tumors at high stages which associated with
metastatic lymph nodes.
Squamous cell carcinoma SCC is an important malignancy in
head and neck tumors , Its high stages resulting in poor survival
because of metastasis–especially lymph nodes- and secondary
tumors . lymph nodes LN have biological importance because of
their immunity role as a base of immunity defensive lines and lymphatic fluid purification, Recently chemokine receptors have been reported to be correlated with many malignancies ,In
particular CCR7.
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