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Register a new userComparative Effect of Methalonic Extract of Fenugreek and Nigella Sativa Seeds On Blood Glucose In Diabetic Male Rabbits
مقارنة تأثير الخلاصة الميثانولية لبذور الحلبة و الحبة السوداء على مستوى السكر في الدم عند ذكور الأرانب المصابة بداء السكري
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الهدف من إجراء البحث هو مقارنة تأثير الخلاصة الميثانولية لبذور الحلبة و الحبة السوداء على سكر الدم, عند ذكور الأرانب المصابة بداء السكري بواسطة الألوكسان, من أجل ذلك تم استخدام 42 من ذكور الأرانب قسمت إلى سبع مجموعات حيث ضمت كل مجموعة 6 أرانب.
The specific aim of this study was to investigate the effects of Methalonic Extract of Fenugreek and Nigella Sativa On Glucose Levels In Blood In Diabetic Male Rabbits. The experiment was carried out on(42) At Diabetic Male Rabbits divided into(7) groups (6) animals of each.
References used
Adamska,M.,Lutomski,J C. 1971- flavonoid glycosides in the seeds of Trigonella foenum graecum [in German].Planta Med .20:224-229
AL-Habori,M.,Raman.A.,Lawrence,M.J.,SKett,P. 2001-:In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A.Int J Exp Diabetes Res2(2):91-9
Al-ksoy, S.T Turkey ,M.tuter,G ustun.and Sriva,F. S.2001- Nvestiction of substrate selectivity of Nigella sativa seed Lipase.J.Ethnopharmacol.,76:65-8
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The specific aim of this study was to investigate the effects of of
Methalonic Extract of Fenugreek and Nigella Sativa Seeds on blood
profile in Male Rabbits The experiment was
carried out on(30) of Male rabbits divided into(5) groups (6)
animals of each.
A trial was carried out to study the possibility of using
fenugreek powder in the treatment of diabetes type(2). 48
Newzealand white male rabbits ( five months old)were used
in this experiment.Theexperimental animals were randomly
divided into fo
ur groups. By using Aloluxan, we enforced
diabetes type2 in three of the four groups of the
experimental animals. The animals of the fourth group
remained as a natural healthy control.
This study was conducted in the laboratories of the Faculty of Science In the spring
on 2013, after being subjected to gavage for 4 weeks through a standard diet supplemented
fat by 3% to two groups (6animales per group) the experimental group beca
me aqueous
extract 150 mg/kg Body weight for 4weeks while the control group became standard food
and tap water ad libitum.
The Blood samples were collected each week, and then the serum samples were
taken to the biochemical tests to determine total cholesterol, triglycerides and glucose
levels in biochemistry laboratory of the Institute of Intermediate medical in Tishreen
University.
For studying the effect of cadmium sulphate on some physiological components
of blood in male white rabbits. we used (12) animals divided in to two groups (6 animals
per group).the experimental one became aqueous cadmium sulphate (5 mg/kg) orally,
while the control became water for 28 days (4 weeks).
We reported significant decrease (p<0.01) in the count of red blood cells ,
Hematocrit values and Hemoglobin concentration.
A known weight of Abrus seeds powder were soaked in cِhloroformmethanol
(2:1) and extracted for 18 hours, the mixture then filtrated and reextracted
with equal volume of water and evaporated to dryness. The crude
extract is regarded as cِhloroform
-methanol extract of Abrus Seeds (crab's eye).
Chloroform-methanol extract was analyzed by HPLC and GC-MS
chromatography for identification and purification of the extract components.
Trigonelline and Abrine were isolated, a solution of a definite concentration
was made from crab's eye extract and its pure components, trigonelline and
Abrine, then oral administration of this solution of a definite concentration
were given to the Alloxan diabetic rats.
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