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Register a new userتأثير تعاطي الميتفورمين على فاعلية إنزيم غلوتاتيون بيروكسيداز و إنزيم سوبر اوكسيد ديسموتاز عند المرضى السكريين نمط II و الأفراد الأسوياء
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Aِl-Baath University ورقة بحثية
Publication date
2016
fields
Pharmacy
and research's language is
العربية
Authors
بديع صيرفي( باحث )
Created by
Shamra Editor
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يتصف الداء السكري بزيادة الاجهاد التأكسدي، و زيادة تشكل الجذور الحرة مما يسبب انخفاض فاعلية الجمل المضادة للتأكسد و منها الجمل الإنزيمية: غلوتاتيون بيروكسيداز و سوبر أوكسيد ديسموتاز . للميتفورمين دور كمضاد للتأكسد فيو يعمل على تفعيل الإنزيمات السابقة . تمت مقايسة المتثابتات التالية في المصل: الغلوكوز، الكوليستيرول، ثلاثيات الغليسيريد، و مقايسة الفاعلية الإنزيمية لكل من: الغلوتاتيون بيروكسيداز و السوبر اكسيد ديسموتاز في الكريات الحمر عند الافراد الاصحاء و مرضى السكري نمط II. أوضحت الدراسة وجود انخفاضاً في فاعلية هذه الإنزيمات عند السكريين، مقارنة مع الأفراد الأصحاء، و بينت وجود علاقة قوية و طردية بين تعاطي الميتفورمين و فاعلية كل من الغلوتاتيون بيروكسيداز و السوبر أوكسيد ديسموتاز.
No English abstract
References used
AA,ABD.Elaneea,AA.Moustaf,AMMouhamed(2014): Modulation 0f the oxidative stress by Metformin in the cerebrum of Rats exposed to global cerebral ischemia and ischemia reperfusion . Eu,Re,Med,Pha,Sci,No(18):2387-2392
Anilak.Madraju.Derk M,Erion(2014):Metformin suppross gluconeogenesis by inhybtingMetocondrial glycerphosphate Dehydrogenase .letter.macmilan publshers limited 13270
Alise Silova (2015):changes in oxidative stress parameters and correction opporrbunites in particular pathology.doctoral thesis- Biochemistry. Riga 2015
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يستخدم الميتفورمين كخط علاجي أول لضبط داء السكري من النمط الثاني غير المضبوطين بالحميه خاصة عند المرضى زائدي الوزن
Background: Diabetes mellitus is a leading public health problem with increasing
incidence and long term complications. These complications are mainly a consequence of
macro-vascular and microvascular damages of the target organs. The incidence of
several
pulmonary abnormalities during the course of Diabetes Mellitus because the presence of
an extensive microvascular circulation and abundant connective tissue in the lungs , raises
the possibility that lung tissue may be a target organ in diabetic patients.
Objectives: This research is designed to study the impact of DM and both the
duration of the disease and the glycemic control on pulmonary function tests.
Methodology: This is a cross-sectional study carried out on 75 patients with type II
diabetes mellitus patients at Tishreen University Hospital in the period between October
2015 and October 2016 .We compared with a control group consisted of 75 non diabetic
healthy persons . Measurement of HbA1C , fasting plasma glucose
(FPG) , and spirometry were made to all subjects and the following pulmonary function
parameters were recorded: Forced Expiratory Volume in the first second (FEV1), Forced
Vital Capacity (FVC), and Forced Expiratory Volume percent (FEV1/ FVC%) . Results
were analyzed by calculating Mean ± SD, using X2 test , Karl Pearson correlation and
ANOVA test.
Results: The mean FEV1, FVC, FEV1/FVC% values were low in diabetics (p value
<0.05) compared to healthy non-diabetics (control group). Also, uncontrolled diabetics
show a greater decrease in these values than controlled diabetics. There was a greater
decrease in these values in patients with long period of disease .
Conclusion: The findings of the present study suggest that, the lung is a target organ
for damage in DM and diabetics show a decrease in PFTs with a restrictive pattern lesion
compared with non-diabetics . And this deterioration is exaggerated in uncontrolled
diabetics and with the long duration of DM .
تعرف الجمعية الأميركية السكري بأنه مجموعة من الاضطرابات الاستقلابية تتميز بفرط غلوكوز الدم نتيجة نقص في افراز الانسولين او مقاومة عمله او كليهما معا
Heart disease, particularly coronary artery disease is a major cause of
morbidity and mortality among patients with diabetes mellitus .
In addition to the increased clinical incidence of coronary artery disease ,
the extent of coronary arteries st
enosed is also greater among diabetics .
T his study showes that diabetics, compared to non-diabetics ,have a higher
incidence of multiple vessel disease (٨٤٪ vs ٤٨٪) and lower incidence of one
vessel disease .
It also showes that left ventricular function and left ventricular wall
movement are more impaired in diabetics .
Some characteristics of β-galactosidase enzyme that was isolated from a new
born goat brain were studied. This study concluded that the enzyme is glucoenzyme
in which the carbohydrate part constitutes 22.1% in accordance with
phenol –sulfate acid
method.
The optimum pH for the enzyme activity is 5.5. The enzyme lost its activity
completely at pH8.5, and showed great stability at the range of pH 4-6.
The results indicated that the optimum temperature for the enzyme activity
is 55Co at the optimum pH. The stability temperature for the enzyme is
35-60Co.
The analytical results of 5%lactose solution hydrolyzed by the enzyme have
indicated that the hydrolysis rate is between 40% after 60 minutes, to 95%
after 270 minutes.
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