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Register a new userStudy of Intestinal Absorption of Telmisartan and Drug Interactions in Rats
دراسة الامتصاص المعوي و التداخلات الدوائية لتيلميزارتان عند الجرذان
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Aِl-Baath University ورقة بحثية
Publication date
2016
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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تيلميزارتان من خافضات الضغط المثبطة لمستقبلات أنجيوتنسين II نمط AT1, وقد أظهرت الدراسات له تداخلات دوائية مختلفة الأهمية، و قد هدفت هذه الدراسة لاختبار دور بعض المواد الفعالة المؤثرة في نواقل الاندفاع و الدفع و انزيمات الاستقلاب في امتصاص تيلميزارتان من الأمعاء ما قبل تأثير العبور الكبدي. طبقت لدى الجرذان تقنية الإرواء المعوي مع الاعتيان الوريدي بإرواء تيلميزارتان ضمن اللمعة المعوية و قياس تركيزه و كميته مع الزمن.
Telmisartan is an antihypertensive drug that inhibits angiotensin II receptors type AT1. Studies showed drug interactions with different potentials. This study was intended to investigate the role of some active ingredients acting on influx, efflux and metabolizing enzymes in intestinal absorption of telmisartan prior to hepatic-pass effect. Intestinal perfusion with venous sampling technique was applied in rats by perfusing telmisartan in intestinal lumen, and measuring its concentration and amount versus time.
References used
SWEETMAN SC, 2009- Martindale- The Complete Drug Reference, Pharmaceutical Press, 36th edition, USA, 3694 p
LIU HJ, LIAO HH, YANG Z, et al, 2016- Peroxisome proliferator-activated receptor-γ is critical to cardiac fibrosis, PPAR Research, 1-12
SHIMASAKI M, YAMASHITA K, IMANISHI R, et al, 1999- Pharmacokinetics of 14C-telmisartan. absorption, distribution and protein binding of 14C-telmisartan after a single oral administration to rats, Xenobiotic Metabolism and Disposition, (14)6: 425-431
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This paper presents a new solution that allows the doctors to know drug interactions,
considering other affecting factors such as the patient's age, weight, physiological and
pathological condition. This solution is characterized by being increment
al, not only by
enriching the database with drug interactions information, but also by its ability to conclude
other interactions through a built-in expert system. The system concludes drugs interactions
based on its active substrates and the potential interactions between them or between the drugs
families. The system serves in three ways; it determines whether the patient illness is possibly
due to the medications he is on. It alerts the doctor to the interaction of the newly prescribed
medication with the patient’s medications, and to its influence on the patient’s physiological or
pathological condition. Besides, it suggests alternative drugs when needed. The solution offers
additional services such as binding between the brand name and the generic drug, and between
drugs and diseases.
النظم الخبيرة
التداخلات الدوائية
الحالة الفيزيولوجية
الحالة المرضية
الآثار الجانبية
العائلة الدوائية
المادة الفعالة
الاسم العلمي
الاسم التجاري
الاستطبابات
Expert Systems
Drugs Interactions
Active Substrate
Medical Group
Genuine Name
Trade Name
physiological condition
pathological condition
Side Effects
Indications
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