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Register a new userA Study of Some Factors Influencing Encapsulation Yield& Efficacy When Preparing Microcapsules By Complex Coacervation
دراسة تأثير عدد من العوامل على محصول و كفاءة الكبسلة الدقيقة للباراسيتامول بطريقة التقوصر المعقد
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Added by
Tishreen University ورقة بحثية
Publication date
2016
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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تهدف هذه الدراسة إلى تحضير كبسولات دقيقة لمادة الباراسيتامول كمادة نموذج باستخدام متماثرات محبة للماء هي الجيلاتين من النمط A و الصمغ العربي. حُضرت الكبسولات بطريقة التقوصر المعقد (ComplexCoacervation). و تمت دراسة تأثير عدة متغيرات على كل من محصول الكبسلة (Coacervation Yield) و على كفاءة الكبسلة (Coacervation Efficacy) شملت هذه المتغيرات كل من نسبة اللب إلى الغلاف (اعتُمدت النسب 1:2، 1:4، 1:6), سرعة التحريك (تم العمل على ثلاث سرعات 200 دورة/د، 300 دورة/د، 400 دورة/د ), و نمط التجفيف (هواء الغرفة, محم بدرجة حرارة 26°م). أظهرت النتائج أن زيادة كل من نسبة اللب إلى الغلاف و سرعة التحريك كان لها أثراً إيجابياً, حيث أدى ذلك إلى زيادة في محصول و كفاءة عملية الكبسلة. أما بالنسبة لنمط التجفيف فقد بينت النتائج أن التغيير في نمط التجفيف من هواء بدرجة حرارة الغرفة إلى محم بدرجة حرارة 26ملم يؤثر بشكل ملحوظ على المحصول و الكفاءة حيث كانت النتائج متقاربة في كل منهما عند الانتقال من طريقة تجفيف إلى أخرى. تم الحصول على المحصول و الكفاءة المثاليين عند كل من نسبة لب إلى غلاف 1:6 و سرعة تحريك 400 دورة/د في كلا نمطي التجفيف.
The Objective of this study was to prepare Paracetamol Microcapsules using Gelatin type A and Gum Arabic as a hydrophilic polymers. Microcapsules were prepared by complex Coacervation. Microencapsulation Yield (MEY) and microencapsulation efficacy (MEE) were investigated with respond to three variables including: Ratio of core to wall material (2:1, 4:1, 6:1), Stirring Speed (200, 300, 400) rpm and Drying method (Air at room temperature, Oven at 26ºC). The results showed that increasing core to wall material leads to increase in both MEE & MEY. The same effect was obtained when increasing stirring speed. Finally the change in a way drying leads to unnoticeable change in both MEE & MEY. Optimum MEE & MEY were obtained when using 6:1 core to wall material, 400 rpm in both two ways of drying.
References used
Agnihotri, N.; Mishra, R.;Goda, C.&Arora, M.Microencapsulation – A Novel Approach in Drug Delivery: A Review. Indo Global Journal of Pharmaceutical Sciences, Vol.2, NO.1, 2012, 1-20
Dubey, R.; Shami, T.C.&BhaskerRao, K..U. Microencapsulation Technology and Applications.Defence Science Journal, Vol.59, No.1, 2009, 82-95
Siow,L.F.&Ong, C.S. Effect of pH on Garlic Oil Encapsulation by Complex Coacervation. Journal of Food Process& Technology, Vol.4, NO1, 2013, 1-5
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