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Register a new userEffects of serum testosterone levels after Androgen deprivation therapy on the outcome of patients with prostate cancer
دراسة مستوى التستوستيرون المصلي بعد تطبيق المعالجة المثبطة للأندروجين :ADH عند مرضى سرطان الموثة النقائلي (خبرة مشفى تشرين الجامعي في اللاذقية بين عامي 2013-2014)
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Tishreen University ورقة بحثية
Publication date
2015
fields
Medicine
and research's language is
العربية
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Shamra Editor
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شملت هذه الدراسة 30 مريضا لديهم سرطان موثة نقائلي , راجعوا قسم الأورام في مشفى تشرين الجامعي في اللاذقية بين عامي 2014 -2013 جميع المرضى درسوا من حيث ال score gleason (مشعر غليسون) و العمر و مشعر كتلة الجسم ((BMI. جميع المرضى تلقوا علاج بشادات LHRH(goserelin 3,6 mg) بحقن شهرية تحت الجلد مع مشاركته خلال أول أسبوعين بمثبطات الأندروجين المحيطية. تم عيار ال PSA و ال Testosteron قبل بدء العلاج ثم بعد شهر واحد ثم بعد 6 أشهر من بدء العلاج ,إضافة إلى مراقبة الاّثار الجانبية للعلاج الهرموني المستخدم و النتائج بعد شهر من العلاج: عدم وجود علاقة بين مشعر كتلة الجسم و التستوستيرون. شادات LHRH تحقق نسبة استجابة تقدر ب 90 %بتخفيضها لللتستوستيرون لقيم أقل من 50 نغ/دل و 76% وصل لديهم التستوستيرون لقيم أقل من 20 نغ /دل.أهم الاّثار الجانبية : الاكتئاب 72% و الهبات الساخنة 33% و الصداع 30%.
In this study : 30 patients with metastatic prostate cancer who admitted to the department of Oncology, Tishreen University Hospital, Lattakia, Syria between 2013 and 2014 were grouped according to gleason score , age and body mass index. All patient received treatment with LHRH agonist (goserelin 3,6 mg subcutaneous injection monthly) combined with anti-androgen for two weeks. PSA and testosterone were measured in all patients before treatment then after 1 and after 6 month and the side effects were documented. Results post ADH treatment: There is no relationship between body mass index and testosterone level. Hormonal treatment with LHRH agonist reduced testosterone to 50 ng/dl in 09% of the patients, whereas 76%of the cases achieved testosterone levels 20ng/dl. The most common treatment-related adverse event was depression 72% , hot flash %33 and headache 30%.
References used
MARBERGER ,M; KAISARY,A; Neal D. Shore,N ; Gary S. Karlin, SAVULSKY,C; Mis,M ; Chiara Leuratti, Josep, R; Germa, Clinical Genitourinary Cancer ,Volume 11, Issue 3, September 2013, Pages 325–330.e1
Jentzmik F1, Schnoeller TJ, Cronauer MV, Steinestel J, Steffens S, Zengerling F, Al Ghazal A, Schrader MG, Steinestel K, Schrader AJ 2014 The Japanese Urological Association
Tim M. van der Sluisa, R. Jeroen A. van Moorselaara, Eric J.H. Meulemana, Ronald W. terHaara, Hong N. Buib, Annemieke C. Heijboerb, André N. Visa,Urology Volume 81, Issue 5, May 2013, Pages 1005–1009
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Studies demonstrated a prognostic role for postoperative CA 19-9 in patients with resectable pancreatic carcinoma following surgery. Our study aimed to investigate whether CA 19-9 provided similar prognostic information in patients with advanced unre
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Lung cancer is the major cause of cancer death. S100A7
overexpression has been associated with early stages of
carcinomas . This study aimed to evaluate the levels of serum
S100A7 in lung cancer. Our study contains 63 patients of lung
cancer (46
newly diagnosis patients, 11 treated patients, 6
recurrence patients) and 15 healthy volunteers
يعد السرطان من أهم الأمراض المسببة للوفاة في جميع أنحاء العالم حيث سجل ما يقارب 14 مليون حالة إصابة جديدة و8.2 مليون حالة وفاة في عام 2012 ومن المتوقع أن يرتفع عدد الاصابات بمعدل 70% خلال العقدين القادميين
The study included 1,800 patients who were admitted in the following departments (surgery, internal and gynecology department) at AL- ASSAD University Hospital in Lattakia in 2011-2012 from the age of 40 years and above. The study, which was based on
a built-in statistical form of risk factors for breast cancer, showed that the percentage of the infected was 9,8%. All risk factors including ageing ,obesity, lack or absence of birth, late age at first childbirth, early puberty, late menopause, hormonal treatment, injuring a first degree relative, staying in cities and the size of bras increase the risk of breast cancer and the impact is worth respectively: 0,115-0,387-0,178-0,157-0,143-0,217-0,15-0,030-0,092-0,244-0,212.
A study was done about bleeding in first trimester of pregnancy including 816
patients from 3104 pregnant women(26.28 %) .
The causes was abortion ( %96.07), ectopic pregnancy (%2.69) and hyditidiform
mole (%1.22).
In patients with abortion 486 p
atients suffered from pain with bleeding(%61.09) and
when happeded together the rate of complete abortion elevated .
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high risk factors in patients with abortion were poor and low level of life also the age -35
40 years old(%47.44).
The tubal ectopic pregnancy was the most common and the privious pelvic operation
is one of the most important high risk factors for ectopic pregnancy.
All patients with ectopic pregnancy had amenorrhea with low or no changes in β-
HCG levels and (%86.36) had abdominal pain with changes and pain in the cervixs.
16 patients (%72.72) needed surgical therapy.
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