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Register a new userProgression of Periodontal Disease in Patients with Phenytoin Gingival Overgrowth
تطور المرض حول السني عند مرضى الضخامات اللثوية بالفينوتئين
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رزان خطاب( باحث )
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تعد الضخامة اللثوية إحدى المضاعفات الشائعة لتعاطي مضاد الصرع بالفينوتئين. تهدف الدراسة إلى تقييم تطور المرض حول السني عند المرضى المعالجين بالفينوتئين و دراسة ارتباطه بالضخامة اللثوية و بالعمر و مدة تعاطي الدواء. تم انتقاء 34 مريضاً (20 ذكوراً و 14 إناثاً) تتراوح أعمارهم 9-49 سنة (متوسط العمر 8.29 سنة), يتناولون الفينوتئين لمدة 2-30 سنة (متوسط = 8.11 ) من مراجعي قسم أمراض الأنسجة حول السنية- كلية طب الأسنان- جامعة دمشق. أخذت المعلومات الطبية و القياسات السريرية لمشعر الضخامة اللثوية و مشعر عمق السبر و مشعر النقاط النازفة و الصور الشعاعية البانورامية لكل مريض. استخدم عامل الارتباط (r (Correlation لدراسة الترابط بين المشعرات حول السنية و العمر و مدة استعمال الدواء.
Gingival overgrowth (GO) is one of many side effects of phenytoin (PHE) antiepleptic agent. The aim of this study was to evaluate the development of peiodontitis in patients taking PHE and its relation with GO, age, duration of drug administration. Thirty-four patients (14 females, 20 males: range 9-49 years; mean age 29.5) undergoing PHE treatment (range 2-32 years; mean 11.8) from the department of periodontology, faculty of dentistry, Damascus University was included in the study. Medical history including drug duration and clinical measurement of GO index, probing depth (PD) periodontal pocket bleeding points index (BPI) and panoramic radiographs for bone loss (BL), were performed for each patient. For statistical analysis Correlation test (r) was used to determine the correlation between age, duration and periodontal indices.
References used
International Workshop for a Classification of Periodontal Diseases and Conditions. Papers. Oak Brook, Illinois, October 30- November 2, 1999. Ann Periodontol. 4:i, 1-112; 1999
Nishikawa S, Nagata T, Morisaaki I, Oka T, Ishida H. Pathogenesis of drugs induced gingival overgrowth. A review of studies in the rat model. J Periodontol 1996; 67: 463-471
Butler RT, Kalkwart KL, Kaldahl WB. Drugs induced gingival hyperplasia: phenytoin, cyclosporin and nifidipine. J Am Dent Assoc 1987; 114:56-60
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It is recognized that Cerebral Palsy (CP) can have
direct and indirect effects on oral health status, and that results in
Gingivitis, periodontitis and other oral diseases, because of their
inability to control muscle function and that makes oral hygiene
maintenance is a difficult task for patients.
Objectives: to assess the gingival and periodontal status in patients
with CP and compare that to their healthy siblings.
The aim of this study was to compare the effects of
gingivectomy by using traditional surgery procedure and Er:YaG
laser depending on the following clinical indications: the pain
after 2 hours and 24 hours of surgery procedure, healing of
gum aft
er surgery depending on rosiness and polypus
indications after removing periodontal dressing and gingival
bleeding during and after surgery.
Early and accurate detection of kidney involvement in primary and secondary glomerulopathy, and therapeutic regimen mayimprove outcomes. Renal biopsy is required for definitive diagnosisof renal disease.
This study investigated whether patients with
proteinuria < 1500 my/24 h without ARF have significant renal disease and should be biopsied. 50 patientsunderwent kidney biopsies during 2011-2013 in Al-Assad University Hospital and Al-Mousah University Hospital in Damascus. Sixteen of them have 24-h urine protein < 1500 mg andnormal kidney function.Female to male ratio was 3:1. Five patients(31.25%) have MN, 3 patients (18.75%) have FSGS, 2 patients (12.5%) have MCD, one case (6.25%) MPGN, and finely 5 patients (31.25%) have LNfrom which there is a case with class I,2 cases with class III(superimposed classV),and a case with IV(superimposed classV), and one case with class V.Out of 8 patients without hematuria at the time of biopsy, 2 (25%) had MN, 2 (25%) had FSGS,one patient(12.5%) MCD, 3 patients(37.5%) had LN.Three patients (18.75%) hadproteinuria <500 mg/24 h, andwere diagnosed with (MN,MCD,MPGN).Our findings showa significant renal involvement(MN-FSGS-MPGN-LN), whichreveals the importanceof conducting biopsyearly and routinely in the patient population.
renal biopsy
proteinuria
(Focal Segmental Glomerulosclerosis (FSGS
(Membranous Nephropathy (MN
(Lupus Nephritis (LN
(Membranoproliferative Glomerulonephritis (MPGN
(Minimal Change Disease (MCD
خزعة الكلية
بيلة بروتينية
تصلب كبي قطعي بؤري
التهاب كبب و كلية غشائي تكاثري
اعتلال كلوي ذئبي
اعتلال كلوي غشائي
الداء قليل التبدلات
المزيد..
Purpose: Lacunar infarcts is an important stroke subgroup with unique clinical and
pathologic features, but risk factors for lacunar infarcts have been rarely documented. To
address this matter, we studied 65 patients had lacunar infarction at Depa
rtment of
Neurology , Tishreen University Hospital , Lattakia , Syria , and 65 controls during the
period between May 2017 – May 2018 .
Methods: We obtained information concerning risk factor exposure status among the
patients by a structured questionnaire , we recorded age , sex , blood pressure , glucose ,
heart diseases , cigarette smoking , alcohol drinking , physical exercise for patiens and
controls .We do laboratory tests and ECG and echocardiography and CT brain or MRI .
Results: Significantly increasing the risk of lacunar stroke were hypertension
(P-value=0.0001) and (OR=9.9), Current smokers (P-value=0.002) and (OR=5.2), diabetes
(P-value=0.001) and (OR=5.3) , whereas frequent physical exercise was associated with a
significantly decreased risk) P-value=00001( and (OR=2.6). There was no risk of
lacunar stroke associated with heart disease (P-value=0.6) (OR=0.8) , high cholesterol (Pvalue=
1) and (OR=1) , alcohol drinking (P-value=0.7) and (OR=0.8).
Conclusions: Patients with hypertension or diabetes, current smokers, those who
have not heart disease, are at a higher risk of lacunar stroke, whereas those who undertake
regular physical exercise may be at lower risk.
Compliance of treatment regimens considers one of the challenge the end-stage renal
disease patients, because of its highly cost related to medication, sessions, diets and the life
style modification.
Objective: to assess the compliance of end-sta
ge renal disease patients with
treatment regimens. Setting: The study was carried out in all the hemodialysis departments
in the governmental hospitals in Lattakia. These were Al-Assad Hospital- Public Lattakia
Hospital- Military Hospital- Jablah Public Hospital- Al-Kurdaha Public Hospital- Al-Hafa
Public Hospital. Subjects: the study consisted 230 patients of the hemodialysis department
in the time of study from the first of November to April 2014. Tool: patients were
interviewed individually to collect the necessary data using tool I, their compliance with
treatment regimen were assessed using tool II. Results: only 2.17% of the patients were
compliance with prescribed treatment regimen. Their compliance was affected by some
factors like the hospital where they got sessions, monthly income, and with the date of
beginning treatment.
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