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Clinical and Pathological Characteristics of Primary Bladder Cancer at Damascus University Hospitals

الصفات السريرية و الباثولوجية لسرطان المثانة الأولي في مشافي جامعة دمشق

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 Publication date 2011
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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Bladder cancer is the second most common urogenital tumor. The stage, grade, number and diameter of urinary bladder cancer is an important factors in determining prognosis of the disease. Early diagnosis and proper treatment are also critical to improve survival. This retrospective study was performed to determine the clinico-pathological features of primary bladder cancer at first presentation at Damascus University hospitals.


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Research summary
تتناول هذه الدراسة الصفات السريرية والباثولوجية لسرطان المثانة الأولي عند المرضى المراجعين لمشافي جامعة دمشق. أجريت الدراسة بشكل استرجاعي وشملت 96 مريضًا خلال الفترة من يناير 2009 حتى يونيو 2010. كانت نسبة الذكور إلى الإناث حوالي 4:1، وكان متوسط العمر 62 عامًا. أظهرت النتائج أن معظم المرضى كانوا مدخنين (64.58%) وأن العرض الأكثر شيوعًا كان البيلة الدموية العيانية (82.29%). كان النمط النسيجي الأكثر شيوعًا هو السرطانة البولية (94.79%)، وكانت معظم الأورام في المرحلة T1 (41.67%). أظهرت الدراسة أن الأورام الغازية للعضلية كانت موجودة عند 34.38% من المرضى، وأن الأورام عالية الدرجة (G3) كانت الأكثر شيوعًا (37.5%). خلصت الدراسة إلى أن معظم أورام المثانة كانت من نوع السرطانة البولية، وأنها كانت أكثر شيوعًا عند الذكور ومع تقدم العمر. أكدت الدراسة على أهمية نشر الوعي الصحي بين المرضى والأطباء حول أعراض البيلة الدموية ومخاطر التدخين لتحسين ظروف التشخيص والمعالجة.
Critical review
دراسة نقدية: تعتبر هذه الدراسة مهمة جدًا لفهم الصفات السريرية والباثولوجية لسرطان المثانة في سوريا، ولكن هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الأفضل تضمين مجموعة مقارنة من غير المدخنين لتحديد تأثير التدخين بشكل أكثر دقة. ثانيًا، لم تتناول الدراسة العوامل البيئية والمهنية التي قد تؤثر على نسبة الإصابة بالسرطان. ثالثًا، كان من الممكن استخدام تقنيات تشخيصية أكثر حداثة مثل التصوير بالرنين المغناطيسي لتحسين دقة التشخيص. وأخيرًا، كان من المفيد إجراء متابعة طويلة الأمد للمرضى لتحديد تأثير العلاجات المختلفة على البقاء على قيد الحياة.
Questions related to the research
  1. ما هي النسبة الأكبر من المرضى الذين شملتهم الدراسة؟

    النسبة الأكبر من المرضى كانوا من الذكور بنسبة 81.25%.

  2. ما هو العرض الأكثر شيوعًا بين المرضى؟

    العرض الأكثر شيوعًا كان البيلة الدموية العيانية بنسبة 82.29%.

  3. ما هو النمط النسيجي الأكثر شيوعًا لسرطان المثانة في الدراسة؟

    النمط النسيجي الأكثر شيوعًا كان السرطانة البولية بنسبة 94.79%.

  4. ما هي المرحلة الأكثر شيوعًا للأورام في الدراسة؟

    المرحلة الأكثر شيوعًا كانت T1 بنسبة 41.67%.


References used
Jemal A, Siegel R, Ward E et al. Cancer statistics, 2005. CA Cancer J Clin 2006; 56: 106–30
Edward M. Messing, Urothelial Tumors of the Bladder. Wein: Campbell-Walsh Urology, 9th ed. 2007 Saunders, section XV, Chapter 75, p2732
Stephen Jones, Steven C. Campell, Non–Muscle-Invasive Bladder Cancer (Ta, T1, and CIS) ,Wein: Campbell-Walsh Urology, 9th ed.2007, Saunders, section XV, Chapter76, p2785-2787
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