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The Epidemiology of Lung Cancer (16- Year Experience of Alassad University Hospital in Damascus)

دراسة الخصائص الوبائية و السريرية لسرطان الرئة البدئي (خبرة 16 عاماً في مشفى الأسد الجامعي بدمشق)

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 Publication date 2013
and research's language is العربية
 Created by Shamra Editor




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We retrospectively reviewed data of all patients who underwent study or surgery for Lung Cancer from (1997 to 2012) in the department of thoracic surgery at Alassad University Hospital in Damascus. There were 2029 patients with Lung cancer,1727 male 85,11% and 302 female 14,88%,87,53% of patients were smoking, and cough was the most common symptom about 70% of patients. There were 889 squamous cell carcinoma 43,81%, 702 adenocarcinoma 34,79%, 246 small cell carcinoma 12,12%,67 large cell carcinoma 3,3% and 66 carcinoid tumor 3,25%; the staging was 6,35% stageI,14,98% stageII,15,91% stage IIIA,29,02% stageIIIB,33,71% stage IV. Radical Surgery consisted of 621 formal lung resection 229 lobectomies 36,87%, 163 bilobectomies 26,2%, 158 pneumonectomy 25,44%,35 sleeve or bronchoplastic resection 5,63% ,36 partial resection 6,15%. The perioperative mortality was 3,05% and the overall 5 year survival was 22,9%. Our study resembles most of the studies made in the developing countries in the result that the rate of smoking and of lung cancer among women is fewer compared to the International rate. It also resembles most of the European countries in the result that squamous cell carcinoma is the most common pathological pattern, and the size of pulmonary resection is bigger than that in the developed countries where they have earlier diagnosis. Moreover, the rate of the sleeve resection surgery along with the rate of mortality resemble that of the International centers.


Artificial intelligence review:
Research summary
تستعرض هذه الدراسة الخصائص الوبائية والسريرية لسرطان الرئة في مشفى الأسد الجامعي بدمشق على مدى 16 عامًا (1997-2012). شملت الدراسة 2029 مريضًا، منهم 1727 رجلًا و302 امرأة، وكانت نسبة المدخنين 87.53%. كان السعال العرض الأكثر شيوعًا بنسبة 70%. توزع المرضى حسب الأنماط النسيجية إلى كارسينوما شائكة الخلايا (43.81%)، كارسينوما غدية (34.79%)، كارسينوما صغيرة الخلايا (12.12%)، كارسينوما كبيرة الخلايا (3.3%)، وكارسينوئيد (3.25%). توزع المرضى حسب التصنيف المرحلي إلى 6.35% في المرحلة I، و14.98% في المرحلة II، و15.91% في المرحلة IIIA، و29.02% في المرحلة IIIB، و33.71% في المرحلة IV. أجريت 621 جراحة جذرية، وكانت نسبة الوفيات حول الجراحة 3.05%، ومعدل البقيا الإجمالية لخمس سنوات 15.5%. تقارن الدراسة نتائجها مع الدول النامية والمتقدمة، مشيرة إلى أن نسبة الإصابة بين النساء أقل بكثير من النسبة العالمية، وأن حجم الاستئصال الرئوي أكبر بسبب التشخيص المتأخر.
Critical review
دراسة نقدية: تقدم الدراسة تحليلًا شاملاً لسرطان الرئة في سوريا، ولكنها تفتقر إلى بعض الجوانب التي قد تكون مفيدة. على سبيل المثال، لم تتناول الدراسة تأثير العوامل البيئية الأخرى غير التدخين على انتشار المرض. كما أن الدراسة لم تقدم تحليلًا مفصلًا للعلاجات غير الجراحية وتأثيرها على معدل البقاء. بالإضافة إلى ذلك، كان من الممكن أن تكون المقارنة مع الدول الأخرى أكثر تفصيلًا لتوضيح الفروقات بشكل أكبر. بشكل عام، تعتبر الدراسة قيمة ولكنها تحتاج إلى مزيد من التفصيل في بعض الجوانب لتحسين فهمنا لسرطان الرئة في المنطقة.
Questions related to the research
  1. ما هي نسبة المدخنين بين مرضى سرطان الرئة في الدراسة؟

    بلغت نسبة المدخنين بين مرضى سرطان الرئة في الدراسة 87.53%.

  2. ما هو العرض السريري الأكثر شيوعًا بين مرضى سرطان الرئة في الدراسة؟

    كان السعال العرض السريري الأكثر شيوعًا بين مرضى سرطان الرئة بنسبة 70%.

  3. ما هي الأنماط النسيجية الأكثر شيوعًا لسرطان الرئة في الدراسة؟

    كانت الأنماط النسيجية الأكثر شيوعًا هي كارسينوما شائكة الخلايا (43.81%)، كارسينوما غدية (34.79%)، وكارسينوما صغيرة الخلايا (12.12%).

  4. ما هو معدل البقاء الإجمالي لخمس سنوات لمرضى سرطان الرئة في الدراسة؟

    بلغ معدل البقاء الإجمالي لخمس سنوات لمرضى سرطان الرئة في الدراسة 15.5%.


References used
Philip, W.Smith;David, R.Jones .Biology And Epidemiology of Lung Cancer. Pearson's Thoracic &Esophagial Surgery,volum1,3th Edition, Churchill Livingston Elsevier 2008:708- 728
Thomas, W.Shields.Pathology of Carcinoma of the Lung,General Thoracic Surgery ,Vol2,7th Edition,Lippincott Williams&Wilkins 2009:1311-13372007;2:706-714
Danny, R.Youlden;Susanna, M.Cramb; Peter, D.Baade.The International Epidemiology of Lung Cancer Geographical Distribution and Secular Trends.Journal of Thoracic Oncology,Volume 3,Number 8,August 2008:819-831
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