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Renal Transplantation in Patients with Lower Urinary Tract Abnormality

غرس الكلية عند مرضى تشوهات السبيل البولي السفلي

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 Publication date 2009
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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Back pound: Patients with end stage renal disease (ESRD) and lower urinary tract anomalies (LUTA) are often considered high risk for renal transplantation. Methods and subjects: To evaluate the degree of risk, we have reviewed our experience of 17 patients with (ESRD) and (LUTA). The study was carried out in Almoussat university hospital, between 5/ 2003 and 5/2009. After a detailed urological assessment, the patients had been undergone either non-continent cutaneous diversion (Bricker) (Two patients) or continent cutaneous diversion with bladder augmentation (14 patients), before renal transplantation. Results: The patient and graft survival rates were 84.62% and 100%, respectively. The presence of an ileal conduit did not adversely affect graft survival. And the commonest complication was persistent urinary tract infection, which occurred in all patients (100%), but didn’t cause any graft loss. However two patients died because of systemic infections and their graft function was good. Conclusion: Renal transplantation is a satisfactory option for patients with ESRD due to LUTA, but it is important to carry out detailed urological assessment prior to the transplant procedure.


Artificial intelligence review:
Research summary
تتناول هذه الدراسة موضوع غرس الكلية لدى المرضى المصابين بتشوهات في السبيل البولي السفلي (LUTA) والذين يعانون من القصور الكلوي النهائي (ESRD). أجريت الدراسة على 17 مريضًا في مستشفى المواساة الجامعي بين مايو 2003 ومايو 2009. تم تقسيم المرضى إلى مجموعتين: مجموعة خضعت لتحويل بولي غير مستمسك على الجلد (Bricker) ومجموعة أخرى خضعت لتحويل بولي مستمسك على الجلد مع تكبير المثانة. أظهرت النتائج أن نسبة بقاء المرضى والكلية المغروسة كانت 84.62% و100% على التوالي. كانت المضاعفة الأكثر شيوعًا هي الخمج البولي المتكرر، الذي حدث عند جميع المرضى ولكنه لم يؤد إلى فقدان الكلية المغروسة. توفي مريضان بسبب انتانات جهازية، وكانت وظيفة الكلية المغروسة جيدة لديهما. خلصت الدراسة إلى أن غرس الكلية لدى المرضى المصابين بتشوهات السبيل البولي السفلي هو خيار مرض وآمن، بشرط إجراء تقييم دقيق للجهاز البولي السفلي قبل العملية.
Critical review
دراسة نقدية: تعتبر هذه الدراسة مهمة في مجال زراعة الكلى، حيث تقدم بيانات قيمة حول نجاح غرس الكلية لدى المرضى المصابين بتشوهات السبيل البولي السفلي. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة صغير (17 مريضًا فقط)، مما قد يؤثر على تعميم النتائج. ثانيًا، لم يتم تقديم تفاصيل كافية حول العوامل الأخرى التي قد تؤثر على نتائج الغرس مثل الحالة الصحية العامة للمرضى والعلاج المناعي المستخدم. أخيرًا، لم يتم مناقشة التكلفة الاقتصادية لهذه الإجراءات، وهو جانب مهم يجب مراعاته في الدراسات المستقبلية.
Questions related to the research
  1. ما هي نسبة بقاء المرضى والكلية المغروسة خلال مدة الدراسة؟

    نسبة بقاء المرضى كانت 84.62% ونسبة بقاء الكلية المغروسة كانت 100%.

  2. ما هي المضاعفة الأكثر شيوعًا التي واجهها المرضى في الدراسة؟

    المضاعفة الأكثر شيوعًا كانت الخمج البولي المتكرر، الذي حدث عند جميع المرضى.

  3. ما هي أنواع التحويل البولي التي خضع لها المرضى قبل غرس الكلية؟

    المرضى خضعوا إما لتحويل بولي غير مستمسك على الجلد (Bricker) أو تحويل بولي مستمسك على الجلد مع تكبير المثانة.

  4. ما هو الاستنتاج الرئيسي للدراسة؟

    الاستنتاج الرئيسي هو أن غرس الكلية لدى المرضى المصابين بتشوهات السبيل البولي السفلي هو خيار مرض وآمن، بشرط إجراء تقييم دقيق للجهاز البولي السفلي قبل العملية.


References used
Ewatt DH, Allen TD. Urinary tract reconstruction in children undergoing renal transplantation. Adv Ren Replace Ther 1996; 3: 69-76
Cairns HS, Leaker B, Woodhouse CRJ, et al. Renal transplantation into abnormal lower urinary tract. Lancet 1991; 338: 1376-1379
Hatch DA et al. Fate of renal allografts transplanted in patients with urinary diversion. Transplantation 1993; 56: 838-842
Lien B, Brekke IB, Sodal G, Bentdal OH, Pfeffer P, Jakobsen A. Renal transplantation and intestinal urinary diversion: a 10-year experience. Transplant Proc 1993; 25: 1338-1339
Kelly WD, Merkel FK, Markland C. Ileal urinary diversion in conjuction with renal homotransplantation. Lancet 1966; 1: 222-226
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