Clinical Manifestations and kinds of kidney illnesses on children with Henoch Schonlein purpura

This research tends to study clinical manifestation and kinds of kidney illnesses on 50 children visited Al-Assad university hospital in Lattakia from January 1st,2007 to January 1st, 2012 aged between one year to 14 years. The study showed that Henoch Schonlein purpura attack both males and females but attack males more (58% males) (42% females) This illness increases in spring and winter (40% in spring) ( 36% in winter) . The study also showed that the illness is systemic disease , mostly attacking skin, joints, gastro intrudes and kidney in which the illness has taken place at 30% in the acute stage and De relapsed stage and the symptoms appeared as varying intensity proteinurea and hematurea

Renal Biopsy in Patients with low level of Proteinuria

Early and accurate detection of kidney involvement in primary and secondary glomerulopathy, and therapeutic regimen mayimprove outcomes. Renal biopsy is required for definitive diagnosisof renal disease. This study investigated whether patients with proteinuria < 1500 my/24 h without ARF have significant renal disease and should be biopsied. 50 patientsunderwent kidney biopsies during 2011-2013 in Al-Assad University Hospital and Al-Mousah University Hospital in Damascus. Sixteen of them have 24-h urine protein < 1500 mg andnormal kidney function.Female to male ratio was 3:1. Five patients(31.25%) have MN, 3 patients (18.75%) have FSGS, 2 patients (12.5%) have MCD, one case (6.25%) MPGN, and finely 5 patients (31.25%) have LNfrom which there is a case with class I,2 cases with class III(superimposed classV),and a case with IV(superimposed classV), and one case with class V.Out of 8 patients without hematuria at the time of biopsy, 2 (25%) had MN, 2 (25%) had FSGS,one patient(12.5%) MCD, 3 patients(37.5%) had LN.Three patients (18.75%) hadproteinuria <500 mg/24 h, andwere diagnosed with (MN,MCD,MPGN).Our findings showa significant renal involvement(MN-FSGS-MPGN-LN), whichreveals the importanceof conducting biopsyearly and routinely in the patient population.

Histological Findings in Renal Biopsies in Patients with Glomerular and Lupus Nephropathies

Renal diseases are an important medical subject because of their prevalence, so to know frequency of glomerular diseases in Syria and compare it with international studies we studied 261 renal biopsies over a period (1/1/2007–31/12/2012), in Al Assad Hospital of the University in Damascus, investigated by light microscopy immunofluorescence. One hundred and ten cases (59.8%) were primary glomerulonephritis from 184 cases of glomerular disease focal/segmental glomerulosclerosis FSGS was the most common type of primary glomerulonephritis found (30.9%) of primary glomerulonephritis), followed by membranous nephropathy(MN) in 29.1 % , IgAnephropathy (IgAN) in 10%, then membranoproliferative glomerulonephritis (MPGN) and minimal change disease(MCD) 9.1% and, crescentic glomerulonephritis (CerGN) in 6.4% and finally postinfectious glomerulonephritis (PIGN) 5.5 % of the secondary glomerulonephritis were (74 cases constituting 40.2% of the biopsies) lupus nephritis(LN) was the most frequently diagnosed disease (85.1% of secondary glomerulonephritis) diabetic nephropathy (DN) was found in 8.1% of cases amyloidosis (AMD) in 6.8%.