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Register a new userThe Role of Hepcidin as a Biomarker of Iron Status in Haemodialysis Patients
دور الهبسيدين كواسم حيوي في تقدير حالة الحديد لدى مرضى التحال الدموي
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أجريت هذه الدراسة لإثبات دور الهبسيدين في تقدير حالة الحديد لدى مرضى التحال الدموي . تناولت الدراسة 88 مريضاً لديهم داء كلوي بمراحله النهائية ESRD)End Stage Renal Disease) و معالجين بالتحال الدموي في قسم الكلية الصناعية في مشفى الأسد الجامعي في اللاذقية. تم قياس تركيز الهبسيدين و تركيز الفريتين, و حساب نسبة إشباع الترانسفرين (TSAT) بعد قياس السعة الكلية الرابطة للحديد (TIBC)، و من ثم تم ربط هذه الواسمات مع الحديد و قورنت من حيث الارتباط الأقوى. تبين من خلال هذه الدراسة أن تركيز الهبسيدين مرتفع لدى جميع مرضى الدراسة، بالإضافة لوجود علاقة ذات دلالة هامة إحصائياً بين الحديد و الهبسيدين، حيث إن قيمة P-VALUE أصغر من 0.05, و هذه العلاقة علاقة عكسية, و قوة الارتباط في هذه العلاقة 40%، و عند المقارنة مع قوة ارتباط الواسمات الأخرى مع الحديد كان للهبسيدين الإرتباط الأقوى . الخلاصة : يمكن أن يشارك ارتفاع مستوى الهبسيدين لدى مرضى التحال الدموي في التنظيم غير الطبيعي للحديد و في مقاومة تكون الكريات الحمر، كما يمكن أن يكون الهبسيدين واسماً جديداً للحديد لدى هؤلاء المرضى.
This study is conducted to assess the role of hepcidin as a biomarker of iron status in haemodialysis patients. The study included88 patients who had end-stage renal disease ( ESRD), and were treated with haemodialysis in the Department of Renal Medicine in Al-Assad University Hospital in Lattakia. Serum hepcidin and ferritinlevelswere measured, and transferrin saturation (TSAT) was calculated after measuringthe total iron binding capacity (TIBC), these markers were then attached with iron and compared to know the hardest correlation. Results show that all the patients had high serum hepcidin levels,there was a statistically significant relation between iron and hepcidin, where P-VALUE smaller than 0.05, this relationship was inversal, hardly 40% the stongest correlation. Conclusion: These findings suggest that the increased hepcidinin haemodialysis patients may contribute to abnormal ironregulation and erythropoiesis, and may be a novel biomarker of iron status and erythropoietin resistance.
References used
Andrews NC .Disorders of iron metabolism.-`N Engl J Med. 341: 1986-1995, 1999
Finch C .Regulators of iron balance in humans .Blood. 84: 1697-1702, 1994
Ganz T .Hepcidin, a key regulator of iron metabolism and mediator of anemia ofinflammation .Blood. 102 (3): 783-788, 2003
Roetto A; Papanikolaou G; Politou M. et al .Mutant antimicrobial peptide hepcidin is associated with severe juvenilehemochromatosis .Nat Genet. 33: 21-22, 2003
Fleming RE .Advances in understanding themolecular basis for the regulation of dietary iron absorption .Curr Opin Gastroenterol. 21: 201-206, 2005
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Worldwide, iron deficiency anemia (IDA) is the most common nutritional deficiency,
and its management remains a challenge in many cases.(OIT)Oral iron therapy, in appropriate
doses and for a sufficient duration, is an effective first-line strategy
for most patients.
But some patients do not experiencean optimal response to(OIT).The need is still
current and clinically relevant for predictors of response to OIT. Hepcidin-25, a major regulator
of iron metabolism, may be use as a reliable guide for the use of iron and be one of
them.112 patientswith IDA were enrolled in this follow up clinical trial, Selected from two
university, hospitals in Damascus between JUNE2015 and JUNE2016. For patients who
met the inclusion criteria, Baseline CBC, iron studies, and serum hepcidin-25 were measured,
and then they received a 14-day course of oral iron (ferrous gluconate 325mg/ 3 times
daily). Patients who achieved <1g/dl increase in Hb in 14 days were categorized as “nonresponders”.
Screening hepcidin levels were (40.18± 86.35) versus (6.37±10.37)(p=
0.041(innonresponders versus responders to oral iron trial. HepcidinCutoff of >14.3 ng/ml,
showed sensitivity of 40%,specificity of 90.2%, andpositive predictive value of 60% andnegative
predictive value of 80% for predicting nonresponsiveness to oral iron.We conclude
that serum hepcidin25predicts poorly nonresponsivenesstooral iron therapy in IDA
patients, but it is superior to ferritin and TSAT for this purpose.
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studied but early diagnosis of carcinoma of bladder remains a
challenge. Survivin is a member of the inhibitor of apoptosis
protein family (IAPs), whose irregular expression is associated with
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resistance, and poor prognosis.
Hepcidin-25 is a peptide hormone plays an important role in
regulating the systematic iron homeostasis. This paper was
conducted to study the correlations of Hepcidin with some iron
status markers and red cell indices among patients with iron
def
iciency anemia (IDA) and healthy controls in Damascus. Our
study comprised 20 IDA patients (Hb≤11 g/dl for men and
women,Tsat≤20% and ferritin <30 ng/dl) and 10 healthy non
IDA controls. Complete hemogram was performed, iron status
markers (serum iron, total iron binding capacity and ferritin)
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Mitochondria are the major organelles in eukaryotic cells primarily responsible for many cellular functions. Recently, a decrease or increase in mtDNA copy number has been increasingly recognized in human cancers.
The aim of this study was to estimate the total amount of phenolic compounds of olive
trees leaves (Olea europaea L.) as Biomarker for the assessment of lead air pollution at
Banias area. Olive trees were selected as the predominant species in the
study area. The
samples were collected from 6 locations at different distances from the vicinity of the
Banias refinery (0.1, 0.5, 2, 4, 6, 10) Km. The dominated wind in the region is western -
southwesterly during the winter (March) and summer (September), The control was taken
from an area about 20 km from the refinery to the north-east (al-Qardahah rural).
The concentration of total phenolic compounds (TPC) during the summer was (45.6-70.85)
mg GAE/g dw and in the control (40.4) mg GAE/g dw, and during the winter the content
of TPC was (35.6-52.9) mg GAE/g dw and in the control (25.8) mg GAE/g dw. The
concentration of Lead (Pb) in unwashed leaves during the summer was (0.879 – 2.170)
ppm and in the control (0.005) ppm, whilst during the winter was (0.479-1.023) ppm and
in the control (0.00083) ppm. The results showed significant differences in the
concentration of total phenolic compounds and lead between sites (Anova test). High
concentration of total phenols and lead in the summer compared to values in winter at all
sites (t-test). The results also showed a negative correlation between the concentration of
total phenolic compounds and lead with the distance from the refinery of Banias. Finally,
The results showed that the TPC can be used as biomarker of lead air pollution in Banias
area.
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