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The Role of Hepcidin as a Biomarker of Iron Status in Haemodialysis Patients

دور الهبسيدين كواسم حيوي في تقدير حالة الحديد لدى مرضى التحال الدموي

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 Publication date 2013
and research's language is العربية
 Created by Shamra Editor




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This study is conducted to assess the role of hepcidin as a biomarker of iron status in haemodialysis patients. The study included88 patients who had end-stage renal disease ( ESRD), and were treated with haemodialysis in the Department of Renal Medicine in Al-Assad University Hospital in Lattakia. Serum hepcidin and ferritinlevelswere measured, and transferrin saturation (TSAT) was calculated after measuringthe total iron binding capacity (TIBC), these markers were then attached with iron and compared to know the hardest correlation. Results show that all the patients had high serum hepcidin levels,there was a statistically significant relation between iron and hepcidin, where P-VALUE smaller than 0.05, this relationship was inversal, hardly 40% the stongest correlation. Conclusion: These findings suggest that the increased hepcidinin haemodialysis patients may contribute to abnormal ironregulation and erythropoiesis, and may be a novel biomarker of iron status and erythropoietin resistance.


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Research summary
أجريت هذه الدراسة لتقييم دور الهيسيدين كواسم حيوي في تقدير حالة الحديد لدى مرضى التحال الدموي. شملت الدراسة 88 مريضًا يعانون من داء كلوي بمراحله النهائية ويخضعون للعلاج بالتحال الدموي في مشفى الأسد الجامعي في اللاذقية. تم قياس تركيز الهيسيدين والفريتين وحساب نسبة إشباع الترانسفرين (TSAT) بعد قياس السعة الكلية الرابطة للحديد (TIBC). أظهرت النتائج أن جميع المرضى لديهم مستويات مرتفعة من الهيسيدين، ووجدت علاقة ذات دلالة إحصائية بين الحديد والهيسيدين (P-VALUE < 0.05) وكانت هذه العلاقة عكسية بقوة ارتباط بلغت 40%. بالمقارنة مع الواسمات الأخرى، كان للهيسيدين الارتباط الأقوى مع الحديد. توصلت الدراسة إلى أن زيادة مستوى الهيسيدين قد تساهم في التنظيم غير الطبيعي للحديد ومقاومة تكون الكريات الحمر، ويمكن أن يكون الهيسيدين واسماً جديداً للحديد لدى مرضى التحال الدموي.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة في فهم دور الهيسيدين كواسم حيوي لتقدير حالة الحديد لدى مرضى التحال الدموي. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة كان محدودًا (88 مريضًا)، مما قد يؤثر على تعميم النتائج. ثانياً، لم يتم تناول العوامل الأخرى التي قد تؤثر على مستويات الهيسيدين مثل النظام الغذائي والأدوية الأخرى. ثالثاً، كان من الممكن أن تكون الدراسة أكثر شمولية إذا تضمنت مجموعة مقارنة من الأفراد الأصحاء. بالإضافة إلى ذلك، لم يتم مناقشة الآثار السريرية المحتملة لاستخدام الهيسيدين كواسم حيوي في إدارة فقر الدم بشكل كافٍ. على الرغم من هذه النقاط، فإن الدراسة تفتح آفاقًا لدراسات مستقبلية أكثر شمولية وتفصيلًا.
Questions related to the research
  1. ما هو الهدف الرئيسي من هذه الدراسة؟

    الهدف الرئيسي هو تقييم دور الهيسيدين كواسم حيوي في تقدير حالة الحديد لدى مرضى التحال الدموي.

  2. ما هي العلاقة بين الهيسيدين والحديد التي توصلت إليها الدراسة؟

    وجدت الدراسة علاقة عكسية ذات دلالة إحصائية بين الهيسيدين والحديد، حيث كانت قيمة P-VALUE أقل من 0.05 وقوة الارتباط 40%.

  3. ما هي الواسمات الأخرى التي تم قياسها في الدراسة؟

    تم قياس تركيز الفريتين وحساب نسبة إشباع الترانسفرين (TSAT) بعد قياس السعة الكلية الرابطة للحديد (TIBC).

  4. ما هي التوصيات التي خرجت بها الدراسة؟

    توصي الدراسة بضرورة معايرة الهيسيدين عند مرضى الداء الكلوي النهائي الموضوعين على التحال الدموي، وقد يكون إعطاء الحديد بالحقن الوريدي مناسبًا لهؤلاء المرضى.


References used
Andrews NC .Disorders of iron metabolism.-`N Engl J Med. 341: 1986-1995, 1999
Finch C .Regulators of iron balance in humans .Blood. 84: 1697-1702, 1994
Ganz T .Hepcidin, a key regulator of iron metabolism and mediator of anemia ofinflammation .Blood. 102 (3): 783-788, 2003
Roetto A; Papanikolaou G; Politou M. et al .Mutant antimicrobial peptide hepcidin is associated with severe juvenilehemochromatosis .Nat Genet. 33: 21-22, 2003
Fleming RE .Advances in understanding themolecular basis for the regulation of dietary iron absorption .Curr Opin Gastroenterol. 21: 201-206, 2005
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