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Subcutaneous Betamethasone Phosphate Sodium Injection as a Treatment for Chalazion

حقن البيتاميتازون فوسفات الصوديوم تحت الجلد كعلاج للبردة

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 Publication date 2013
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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The study aims to investigate the efficacy of subcutaneous Betamethasone phosphate sodium injection in the treatment of chalazion. The research was carried out in Al-Assad Hospital, Tishreen University, Lattakia, in the period from January 2009 to December 2010. The study included 30 patients; their age ranged between 1-54 years. The patients had chalazion treated with an injection (0.2ml) of Betamethasone phosphate sodium in the subcutaneous tissue around the lesion. All injections were given by a single ophthalmologist. No local or topical anaesthetic was used. The patients were monitored after 2 weeks. The injection (half of the first dose 0.1ml) was repeated when the chalazion did not reduce, with a maximum of two more injections given over a 2-week interval. Thirty patients with chalazion were followed up and treated with injection of Betamethasone phosphate sodium into the subcutaneous tissue around the lesion. In 27 patients (90%), the lesion subsided completely. 16 patients (53.3%) had lesions that subsided with one injection. 11 patients (36.7%) had lesions that subsided after the second injection. 3 patients (10%) did not respond to the treatment. The size and duration of the chalazion up till the time of the patients’ visit to the clinic did not significantly affect the outcome of the treatment. Two patients developed depigmentation of the skin at the site of injection. No other major complications were encountered. Subcutaneous injection of the Betamethasone phosphate sodium appears to be a simple and effective treatment for chalazion. Further comparative clinical cases are indicated


Artificial intelligence review:
Research summary
تهدف الدراسة إلى تقييم فعالية حقن البيتاميتازون فوسفات الصوديوم تحت الجلد في معالجة البردة. أجريت الدراسة في مشفى الأسد الجامعي بجامعة تشرين في اللاذقية بين يناير 2009 وديسمبر 2010. شملت الدراسة 30 مريضًا تتراوح أعمارهم بين سنة واحدة و54 سنة. تم حقن المرضى بجرعة 0.2 مل من البيتاميتازون فوسفات الصوديوم في النسيج تحت الجلد حول البردة دون استخدام أي مخدر موضعي. تمت متابعة المرضى بعد أسبوعين، وتم تكرار الحقن بجرعة نصفية (0.1 مل) عند عدم ملاحظة تراجع في حجم البردة. أظهرت النتائج أن 90% من المرضى (27 مريضًا) اختفت لديهم البردة تمامًا، حيث استجاب 53.3% منهم بعد الحقنة الأولى و36.7% بعد الحقنة الثانية. لم يستجب 10% من المرضى للعلاج. لم يؤثر حجم البردة على نتيجة العلاج بشكل كبير، وتم تسجيل حالتين من فقدان الصباغ الموضعي في منطقة الحقن دون ظهور اختلاطات أخرى. توصلت الدراسة إلى أن حقن البيتاميتازون فوسفات الصوديوم تحت الجلد هو علاج بسيط وفعال للبردة، وأوصت بإجراء دراسات مقارنة إضافية لتأكيد النتائج.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة في تقييم فعالية البيتاميتازون فوسفات الصوديوم كعلاج للبردة، ولكن هناك بعض النقاط التي يمكن مناقشتها. أولاً، حجم العينة صغير نسبيًا (30 مريضًا) مما قد يؤثر على تعميم النتائج. ثانيًا، لم يتم استخدام مجموعة ضابطة لمقارنة فعالية العلاج مما يجعل من الصعب التأكد من أن التحسن كان نتيجة للعلاج وليس لعوامل أخرى. ثالثًا، لم يتم توضيح المعايير المستخدمة لاختيار المرضى أو استبعادهم بشكل كافٍ. وأخيرًا، يجب أن يتم توضيح المزيد من التفاصيل حول الآثار الجانبية المحتملة للحقن والتدابير المتخذة لتجنبها. على الرغم من هذه النقاط، فإن الدراسة تقدم نتائج مشجعة وتفتح الباب لمزيد من الأبحاث في هذا المجال.
Questions related to the research
  1. ما هي الفئة العمرية للمرضى المشاركين في الدراسة؟

    تراوحت أعمار المرضى بين سنة واحدة و54 سنة.

  2. ما هي نسبة المرضى الذين استجابوا للعلاج بعد الحقنة الأولى؟

    استجاب 53.3% من المرضى للعلاج بعد الحقنة الأولى.

  3. هل كان هناك أي تأثير لحجم البردة على نتيجة العلاج؟

    لم يكن هناك تأثير كبير لحجم البردة على نتيجة العلاج.

  4. ما هي الآثار الجانبية التي تم تسجيلها خلال الدراسة؟

    تم تسجيل حالتين من فقدان الصباغ الموضعي في منطقة الحقن دون ظهور اختلاطات أخرى.


References used
CHUNG, F; LAI, S; LI, S. Subcutaneous extralesional triamcinolone acetonide injection versus conservative management in the treatment of chalazion. Hong Kong Med J, Vol. 12, N. 4, 2006, 278-281
PERRY, D; SERNIUK, A. Conservative treatment of chalazia. Ophthalmology, Vol. 87, N. 3, 1980, 218-221
PIZZARELLO, D; JAKOBIEC, A;HOFELDT, J; PODOLSKY, M; SILVERS,N. Intralesional corticosteroid therapy of chalazia. Amj Ophthalmol, Vol. 85, N. 6, 1978, 818-821
WATSON, P; AUSTIN J. Treatment of chalazions with injection of a steroid suspension. Brj Ophthalmol, Vol. 68, N.11, 1984, 833-835
DUA, S; NILAWAR, V. Nonsurgical therapy of chalazion. Amj Ophthalmol, Vol. 94, 1982, 424-425
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