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Register a new userThe Incidence of increased intraocular pressure ( I.O.P)after subtenon injection of triamcinolone acetonide
ارتفاع الضغط داخل المقلة (I. O .P) بعد حقن التريامسينولون اسيتونيد تحت التينون
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حبيب يوسف( باحث )
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الهدف: دراسة حدوث ارتفاع I.O.P بعد حقن تريامسينولون تحت التينون الطرق : تمت الدراسة على 40 مريض 50 عيناً تلقوا 40 مغ تريامسينولون تحت التينون لعلاج أمراض مختلفة تمت مراقبة الضغط داخل المقلة و تحديد العيون التي ارتفع فيها الضغط ≥ 5 ملمز و ذروة I.O.P و العلاقة بين I.O.P و العمر و الجنس و نوع المرض وعدد الحقن النتائج : I.O.P ≥ 5 ملمز وجد في 25 عيناً أي 50% من العيون المدروسة بدأ ارتفاع I.O.P بشكل هام بعد شهر من الحقن( 20% ) وصل إلى الذروة بعد 3 أشهر ( 80 % ) و عاد إلى المستوى الأساسي قبل الحقن بعد 10 أشهر يزداد I.O.P عند الشباب 80 % بالأعمار بين 40– 50 سنة وعند الإناث >الذكور ( 59,09% و 42,8%) على التوالي, وبالحقنة الوحيدة أقل من الحقن المتعددة ( 47,3% و 60%)على التوالي لا يوجد علاقة هامة بين نوع المرض المعالج و حقن التريامسينولون تحت التينون الاستنتاج: تعدد الحقن و الأعمار الشابة و خصوصاً بين النساء يزيد نسبة حدوث ارتفاع I.O.P بعد حقن التريامسينولون تحت التينون.
Purpose : to determine the incidence of eyes that have an increase in the intraocular pressure( I.O.P ) after subtenon injection of triamcinolone acetonide . Methods: 40 patient 50 eyes treated with 40 mg subtenon injection of TA for different diseases. The incidence of an I.O.P elevation ≥ 5mmhg was determine, the peak of I.O.P, the relation between I.O.P elevation and the age, gender, the kind of disease and the number of we injections of ta Results : an elevation I.O.P≥ 5mmhg was found in 25 eyes ( 50%) . The I.O.P began to increase significantly from 1 month (20%) The peak of I.O.P after 3 months (80%) and returned to the baseline I.O.P in 10 months . the elevation I.O.P≥ 5 mmhg was significantly related with younger age (80%) between 40-50 years the elevation I.O.P is between females' more in cedence than males (59,59%) females and (42,8%) males, and is less incidence aftere single injection (42.8%) less than multi injection (60%) multiple No significant relation is round between the disease and the incidence of increased I.O.P . Conclusion : repeated injections of TA and injection of younger patients especially women increase the incidence of an I.O.P elevation .
Artificial intelligence review:
Research summary
تهدف هذه الدراسة إلى تحديد نسبة حدوث ارتفاع ضغط العين (I.O.P) بعد حقن التريامسينولون تحت التينون. شملت الدراسة 40 مريضًا (50 عينًا) تلقوا 40 ملغ من التريامسينولون لعلاج أمراض مختلفة. تم قياس الضغط داخل العين على فترات زمنية مختلفة لتحديد العيون التي ارتفع فيها الضغط بمقدار ≥ 5 ملمز، وتحديد العلاقة بين ارتفاع الضغط والعمر والجنس ونوع المرض وعدد الحقن. أظهرت النتائج أن 50% من العيون المدروسة شهدت ارتفاعًا في الضغط بمقدار ≥ 5 ملمز، وبدأ الارتفاع بشكل ملحوظ بعد شهر من الحقن (20%) ووصل إلى الذروة بعد 3 أشهر (80%)، وعاد إلى المستوى الأساسي بعد 10 أشهر. كان الارتفاع أكثر شيوعًا بين الفئات العمرية الشابة (40-50 سنة) وبين النساء (59.09% مقابل 42.8% للرجال). كما أن الحقن المتعددة زادت من نسبة الارتفاع مقارنة بالحقن الوحيدة. لم تكن هناك علاقة هامة بين نوع المرض المعالج وارتفاع الضغط بعد الحقن. خلصت الدراسة إلى أن تكرار الحقن والأعمار الشابة، خصوصًا بين النساء، يزيد من نسبة حدوث ارتفاع الضغط بعد حقن التريامسينولون تحت التينون.
Critical review
تعتبر هذه الدراسة مهمة لأنها تسلط الضوء على تأثيرات جانبية هامة لحقن التريامسينولون تحت التينون، وهي ارتفاع ضغط العين. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الأفضل تضمين مجموعة ضابطة لمقارنة النتائج وتحديد مدى تأثير التريامسينولون بشكل دقيق. ثانيًا، لم يتم توضيح كيفية اختيار المرضى وما إذا كانت هناك أي معايير استبعاد، مما قد يؤثر على تعميم النتائج. ثالثًا، كان من الممكن تقديم تحليل أكثر تفصيلاً للعوامل الأخرى التي قد تؤثر على ارتفاع الضغط مثل التاريخ الطبي للمرضى واستخدام أدوية أخرى. على الرغم من هذه النقاط، تقدم الدراسة بيانات قيمة يمكن أن تكون مفيدة للأطباء في اتخاذ قرارات علاجية مستنيرة.
Questions related to the research
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ما هي نسبة العيون التي شهدت ارتفاعًا في ضغط العين بعد حقن التريامسينولون تحت التينون؟
50% من العيون المدروسة شهدت ارتفاعًا في الضغط بمقدار ≥ 5 ملمز.
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متى يصل ارتفاع ضغط العين إلى الذروة بعد حقن التريامسينولون؟
يصل ارتفاع ضغط العين إلى الذروة بعد 3 أشهر من الحقن بنسبة 80%.
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هل هناك علاقة بين ارتفاع ضغط العين والجنس؟
نعم، الارتفاع في ضغط العين كان أكثر شيوعًا بين النساء بنسبة 59.09% مقارنة بالرجال بنسبة 42.8%.
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ما هي التوصيات التي قدمتها الدراسة بشأن استخدام التريامسينولون تحت التينون؟
توصي الدراسة بالحذر في استخدام التريامسينولون تحت التينون، خصوصًا في الأعمار الصغيرة وعند النساء، وتجنب تكرار الحقن قدر الإمكان، ومراقبة ضغط العين بشكل دوري بعد الحقن.
References used
yumikoyamamoto, md, tsutomukomatsu, mdyujikoura, mdkojinishino, md, phdatsukifukushimamd, phd, hisayukiueno , md. Intraocular pressure elevation after ibtravitreal or posterior sub tenon triamcinolone acetonide injection Canadian journal of ophthalmology volume 43,issue 1 February 2008 ,p 42-47, sciencedirect
sophiebakri md peter k Kaiser ,md, posterior subtenon triamcinolone acetonide for refractory diabetic macular edema American journal of ophthalmology volume 139,issue 2 february 2005,p 290-294
Ryosuke kawamura.makoto. hajimeshinoda. keishinoda . yujiitoh. susumuishida. Incidence of increased intraocular pressure after subtenon injection of triamcinolone acetonide , Americen Journal of gohthalmalogy,juni2011(3);299-304
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