The increasing number of individuals with diabetes suggests that diabetic retinopathy DR is
a major contributor to vision loss. The initial disease is characterized by increased vascular
permeability due to a breakdown in the blood-retinal barrier
BRB, causing macular edema DME,
with a progressive vascular occlusion and retinal neovascularization which are secondary to
ischemia and oxidative stress. Laser photocoagulation and vitrectomy only target advanced stages
of disease. However, despite laser treatment, patients with DME experienced gradual loss of
vision. Intravitreal triamcinolone IVTA reduces the breakdown of BRB and down-regulates the
production of vascular endothelial growth factor VEGF. IVTA may moderately but temporarily
improves visual acuity in cases of DME. Agents that attenuate VEGF action such as bevacizumab
are expected to reduce permeability and neovascularization. Intravitrealbevacizumab IVB reduces
macular edema secondary to central retinal vein occlusion, vascular permeability and fibrovascular
proliferationin. Calcium dobesilate CD is a potent antioxidant, slows vascular proliferation.
Purpose : to determine the incidence of eyes that have an increase in the intraocular pressure( I.O.P ) after subtenon injection of triamcinolone acetonide . Methods: 40 patient 50 eyes treated with 40 mg subtenon injection of TA for different diseas
es. The incidence of an I.O.P elevation ≥ 5mmhg was determine, the peak of I.O.P, the relation between I.O.P elevation and the age, gender, the kind of disease and the number of we injections of ta Results : an elevation I.O.P≥ 5mmhg was found in 25 eyes ( 50%) . The I.O.P began to increase significantly from 1 month (20%) The peak of I.O.P after 3 months (80%) and returned to the baseline I.O.P in 10 months . the elevation I.O.P≥ 5 mmhg was significantly related with younger age (80%) between 40-50 years the elevation I.O.P is between females' more in cedence than males (59,59%) females and (42,8%) males, and is less incidence aftere single injection (42.8%) less than multi injection (60%) multiple No significant relation is round between the disease and the incidence of increased I.O.P . Conclusion : repeated injections of TA and injection of younger patients especially women increase the incidence of an I.O.P elevation .
