Do you want to publish a course? Click here

Comparison of Dissolution Time of Sodium Ceftriaxone Preparations for Injection and Studying the Factors Affecting it

مقارنة زمن انحلال مستحضرات سفترياكسون الصوديوم المُعدَّة للإعطاء حقناً و دراسة العوامل المؤثرة عليها

1576   0   172   0 ( 0 )
 Publication date 2016
and research's language is العربية
 Created by Shamra Editor




Ask ChatGPT about the research

The aim of this study is to compare the dissolution time of six formulations of paranteralSodium Ceftriaxonepreparation, the original product and five generic local ones. The dissolution time was measured precisely as the point at which the dried powder of Sodium Ceftriaxone preparation became a transparent solution on the addition of physiologicalsolution 0,9% of Sodium Chloride. The dissolution time of the six products were different. The measurement of infrared spectroscopy (FTIR) of different powder preparations was conducted, then the weight, the humidity and the morphology of different medical powders were studied to investigate the factors influencing the dissolution time. The difference in dissolution time between the six products was due to differences in powder characteristics such as water content, crystal shape and dimension. It was shown that one local generic product of Sodium Ceftriaxone islook like the original one.


Artificial intelligence review:
Research summary
تهدف هذه الدراسة إلى مقارنة زمن انحلال ستة مستحضرات من سفترياكسون الصوديوم المعدة للإعطاء حقناً، منها المستحضر الأصلي وخمسة مستحضرات جنيسة محلية الصنع. تم قياس زمن الانحلال بدقة عند النقطة التي تصبح فيها البودرة الدوائية لسفترياكسون الصوديوم محلولاً شفافاً بعد إضافة محلول فيزيولوجي من كلوريد الصوديوم 0.9%. أظهرت النتائج أن زمن الانحلال يختلف بين المستحضرات المدروسة. تم استخدام مطيافية الأشعة تحت الحمراء بتحويل فورييه (FTIR) لتأكيد هوية البودرة الدوائية وعدم تخربها، وكذلك تم دراسة المحتوى المائي للبودرة باستخدام تقنية التجفيف بالأشعة تحت الحمراء. وأخيراً، تمت دراسة أبعاد وأشكال البلورات في البودرة باستخدام المجهر الضوئي. أظهرت الدراسة أن الاختلاف في زمن الانحلال يعود بشكل أساسي إلى اختلافات في خصائص البودرة الدوائية كنسبة الرطوبة والشكل البلوري للجزيئات وأبعادها. وقد استطاع أحد المنتجات الوطنية الجنيسة مجاراة المنتج العالمي في زمن انحلاله والخواص الفيزيوكيميائية المختلفة للبودرة.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة نحو فهم العوامل المؤثرة على زمن انحلال سفترياكسون الصوديوم، إلا أن هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الأفضل تضمين عدد أكبر من المستحضرات الجنيسة المحلية لتقديم صورة أشمل عن السوق المحلية. ثانياً، لم يتم التطرق إلى تأثير درجة الحرارة على زمن الانحلال بشكل كافٍ، وهو عامل مهم يجب أخذه في الاعتبار. وأخيراً، كان من الممكن تقديم توصيات أكثر تحديداً حول كيفية تحسين خصائص البودرة الدوائية بناءً على النتائج المستخلصة من الدراسة. على الرغم من هذه النقاط، فإن الدراسة تقدم معلومات قيمة يمكن أن تكون مفيدة في تحسين جودة المستحضرات الدوائية الجنيسة.
Questions related to the research
  1. ما هو الهدف الرئيسي من هذه الدراسة؟

    الهدف الرئيسي من هذه الدراسة هو مقارنة زمن انحلال ستة مستحضرات من سفترياكسون الصوديوم المعدة للإعطاء حقناً ودراسة العوامل المؤثرة عليها.

  2. ما هي التقنيات المستخدمة في الدراسة لتحديد خصائص البودرة الدوائية؟

    تم استخدام مطيافية الأشعة تحت الحمراء بتحويل فورييه (FTIR) لتأكيد هوية البودرة الدوائية وعدم تخربها، وتقنية التجفيف بالأشعة تحت الحمراء لدراسة المحتوى المائي للبودرة، والمجهر الضوئي لدراسة أبعاد وأشكال البلورات.

  3. ما هي العوامل التي تؤثر على زمن انحلال سفترياكسون الصوديوم؟

    العوامل التي تؤثر على زمن انحلال سفترياكسون الصوديوم تشمل نسبة الرطوبة والشكل البلوري للجزيئات وأبعادها.

  4. ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟

    النتائج الرئيسية هي أن زمن الانحلال يختلف بين المستحضرات المدروسة بسبب اختلافات في خصائص البودرة الدوائية، وأن أحد المنتجات الوطنية الجنيسة استطاع مجاراة المنتج العالمي في زمن انحلاله والخواص الفيزيوكيميائية المختلفة للبودرة.


References used
TANGE, M. , HATTORI, Y. , OTSUKA, M. , YOSHIDA, M., HAGINAKA, J. , UCHIDA, T. Comparison of the dissolution rate of Cefteriaxone Sodium preparations for injection. Chem. Pharm. Bull. Vol. 61, Nº 11, 2013, 1121-1129
MANDELL, GL., SANDE, MA. Antimicrobial agents: penicillins, cephalosporins, and other beta-lactam antibiotics. In Gilman AG, (Ed). Goodman and Gilman’s Pharmacological Basis of Therapeutics 8th ed. New York: Pergamon Press 1990 , 1065–1097
Clarke’s Analysis of Drugs and Poisons in pharmaceuticals, body fluids and postmortem material. London, UK, Pharmaceutical Press 2011
rate research

Read More

The present study was prepared to assess the level of potassium in the vitreous humor fluid, to calculate the post mortem interval (PMI) by finding the regression equation and to study the effects of environmental factors like temperature and humidity and age and sex on it.
This study conducted at Deir Al-Hajar Station during the season 2010-2011 to describe the lactation curve of Shami cattle and determine factors affecting its shape compenents. 1120 records of 356 Shami cows collected between 1997 – 2010 were used. Data were subjected to general linear model, and the analysis of variance used to determine the effect of factors. Duncan test was used to compare the means using SAS system (1996) and Incomplete gamma functions were used to estimate the parameters of lactation curve (a, b and on the basis of daily yield of milk. Results indicated that the average values of the gamma parameters were 2.14 ± 0.01 kg for a (beginning of milking ), 0.61 ± 0.02 kg for b (increasing milk production up to peak) and - 0.23± 0.01 kg for c (decreasing milk production from peak to dry). The effect of calving year was significant (p<0.01) on a, and (p<0.05) on b and (p<0.001) on c. The effect of age at calving and sex of calf was significant (p<0.01) on a but non significant on b and c. Season of calving, parity, and interaction between age and parity was not significant on all parameters. It was concluded that improving the productive performance of Shami cattle, requires applying a long term genetic improvement program to select the best herd.
Rural areas form a large part of Syria's coastal area. Linking between these areas and city centers transact of a network of roads. Each of these roads and transport means form the rural transport system which characterized by general characteristi cs of low levels of traffic, economic activity and population density, and long distances between centers such as service centers. The presenting of services, operations and maintenance characterize at high costs, and there are often difficult geographical and natural conditions. Vehicle operating costs refer to costs that vary with vehicle usage, including fuel, tires, maintenance, repairs…etc., which dependent on the mileage. Transportation agencies and maintenance workshops were visited during this study. As well as, interviews have been done with a random sample of public transport drivers working on some rural axes in the coastal area, in order to obtain the required information about the vehicle operating and maintenance costs. The study concluded by identifying the most important factors that may effect on the tariff of passenger transport on rural axes (maintenance of the vehicle, fuel costs, quality of the road .....) and proposing a number of recommendations aimed at improving the public transport system and raising its efficiency in rural areas.
This research defines Khraig, whose production is restricted to Syrian coastal area. Khraig is the oil extracted from olive fruits after blanching, covered fermentation and drying. All qualitative characteristics of this oil are studied: weight, refr active index, saponification number, iodine value, ultraviolet absorption, fatty acids percentages, peroxide value and free acidity percentage determined as oleic acid. The last two parameters are found to be the main causes for the non-conformation of Khraig oil to the Syrian and International standards of virgin olive oil. Hence, it is necessary to study the effects of the abovementioned treatments of olive fruits on the produced oil. The results indicate that increasing either blanching time from five to ten minutes, or time of covered fermentation from two to three days considerably increases peroxide value of the produced Khraig oil exceeding thus the maximum limit set by the Syrian and International standards. In addition, both treatments lower oil quality by increasing its acidity. The results also show that drying olive fruits for two days instead of one day has a negative effect on oil quality by decreasing organoleptic score and increasing both acidity and peroxide value. Sun drying raises organoleptic score and decreases acidity compared to drying in the shade, but it increases peroxide value, and hence decreases the period of oil storability. There is a need for further studies of Khraig oil, especially the effects of the abovementioned processing steps on important oil constituents related to quality, nutritive value and storability such as tocopherols, sterols, and polyphenols. Likewise, the study of the desirable flavor compounds of this oil is also necessary.
In this research, the natural pyrite ore found in Tartous Governorate was described by studying the two samples taken from Hosn Suleiman -Safita (A) and Al Qadmous (B) area, in addition to studying the optimum conditions for pyrite dissolution (pH - time - quantity) with aerobic conditions. The results of X-ray diffraction (XRD) showed that the sample (A) is mainly composed of pyrite mineral and does not contain impurities, while sample (B) is composed of pyrite mineral combined with a small amount of calcite mineral, and these results were confirmed by the result of (FTIR) infrared spectroscopy and Polarised light microscopy (PLM(. The iron percentage in the two samples (A,B) is ranged between (42.6 – 43 %) and the sulfur percentage is between (40 – 53.7 %). With regard to pyrite dissolution, the results showed that pyrite taken from Hosn Suleiman (A) begins to dissolve at pH values less than 4.5, and the contact time is about 6 hours. By Comparing the results of sample (A) with sample (B), we found that the dissolution of sample (A) was about three times less than the dissolution of sample (B), and this is due to the fact that sample (A) contains pure and well crystallized pyrite ore while sample (B) contains pyrite combind with calcite, which increases its solubility.
comments
Fetching comments Fetching comments
Sign in to be able to follow your search criteria
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا