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Measuring Adiponect in Levels for Nominated Cardiac Catheterization Patients

قياس مستويات الأديبونكتين عند المرضى المرشحين للقثطره القلبية

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 Publication date 2014
and research's language is العربية
 Created by Shamra Editor




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This study tries to assess the potential anti-atherosclerotic role of adiponectin. It includes 54 patients at Al-Assad University Hospital in Lattakia, who are candidates for catheterization, and control group of 25 individuals. Serum adiponectin levels have been measured in both groups, and levels of hs-CRP have been also measured in both groups and compared with adiponectin levels. Catheterization has been done to the patients group and the results of angiography are categorized to mild, moderate, and severe coronary artery disease (CAD) according to the SYNTAX SCORE The study concludes that serum adiponectin levels are higher in patients with mild CAD(23.86 μg/ml) compared to patients with moderate to severe CAD (13.62 μg/ml);(p=0.001<0.05). The average serum adiponectin levels in control group was (17.1μg/ml). There was no statistically significant of the relation between the concentration of hs-CRP and the concentration of adiponectin .However, there was a statistically significant difference between the average concentration of hs-CRP in the patients group (7.1 mg/l) and the control group (2.7 mg/l); (P=0.003<0.05).


Artificial intelligence review:
Research summary
تبحث هذه الدراسة في دور الأديبونكتين كمضاد للتصلب العصيدي. شملت الدراسة 54 مريضًا في مستشفى الأسد الجامعي في اللاذقية، المرشحين لإجراء القسطرة القلبية، بالإضافة إلى مجموعة ضابطة من 20 فردًا. تم قياس مستويات الأديبونكتين وhs-CRP في الدم لكلا المجموعتين. أظهرت النتائج أن مستويات الأديبونكتين كانت أعلى لدى المرضى الذين يعانون من إصابات خفيفة في الشرايين التاجية مقارنةً بالمرضى الذين يعانون من إصابات متوسطة إلى شديدة. لم يكن هناك علاقة إحصائية ذات دلالة بين تركيز hs-CRP وتركيز الأديبونكتين، ولكن كان هناك فرق إحصائي بين متوسط تركيز hs-CRP بين المرضى والمجموعة الضابطة. توصي الدراسة بإجراء معايرات للأديبونكتين لجميع المرضى المرشحين للقتطرة القلبية كوسيلة لتحديد شدة الإصابة وتجنب القسطرة غير الضرورية.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة في فهم دور الأديبونكتين في التصلب العصيدي، إلا أن هناك بعض النقاط التي يمكن تحسينها. أولاً، كان حجم العينة صغيرًا نسبيًا، مما قد يؤثر على دقة النتائج. ثانيًا، لم يتم تضمين مرضى السكري في الدراسة، وهذا قد يحد من تعميم النتائج على جميع المرضى المرشحين للقتطرة القلبية. ثالثًا، لم يتم دراسة تأثير العوامل الأخرى مثل الأدوية التي يتناولها المرضى، والتي قد تؤثر على مستويات الأديبونكتين وhs-CRP. أخيرًا، كان من الأفضل تضمين مجموعة أكبر من المرضى من مختلف الأعمار والأجناس للحصول على نتائج أكثر شمولية.
Questions related to the research
  1. ما هو الهدف الرئيسي من الدراسة؟

    الهدف الرئيسي من الدراسة هو تقييم دور الأديبونكتين كمضاد للتصلب العصيدي وتحديد قيمته الإنذارية لدى المرضى المرشحين للقتطرة القلبية.

  2. ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟

    أظهرت الدراسة أن مستويات الأديبونكتين كانت أعلى لدى المرضى الذين يعانون من إصابات خفيفة في الشرايين التاجية مقارنةً بالمرضى الذين يعانون من إصابات متوسطة إلى شديدة، ولم يكن هناك علاقة إحصائية ذات دلالة بين تركيز hs-CRP وتركيز الأديبونكتين.

  3. ما هي التوصيات التي قدمتها الدراسة؟

    توصي الدراسة بإجراء معايرات للأديبونكتين لجميع المرضى المرشحين للقتطرة القلبية كوسيلة لتحديد شدة الإصابة وتجنب القسطرة غير الضرورية.

  4. ما هي العوامل التي لم يتم دراستها في البحث والتي قد تؤثر على النتائج؟

    لم يتم دراسة تأثير العوامل الأخرى مثل الأدوية التي يتناولها المرضى، والتي قد تؤثر على مستويات الأديبونكتين وhs-CRP، كما لم يتم تضمين مرضى السكري في الدراسة.


References used
Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes.J Biol Chem 1995;270:26746-9
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K,et al. The fatderived hormone adiponectin reverses insulinresistance associated with both lipoatrophy and obesity. Nat Med2001;7:941-6
Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med2001;7:947-53
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al.Adiponectin stimulates glucose utilization and fatty-acid oxidation byactivating AMPactivated protein kinase. Nat Med 2002;8:1288- 95
Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M,Matsuda M, et al. Association of adiponectin mutation with type 2diabetes: a candidate gene for the insulin resistance syndrome.Diabetes 2002;51:2325- 8
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