Background and Objective : Bone morphogenic protine-2 (BMP-2) plays an essential
role in mesenchymal cells differentiation into osteoblasts، through many intracellular
pathways which crosses with tumoral pathways . Oral squamous cell carcinoma is a
n
invasive epithelial neoplasm، counts more than 90% of head and neck malignancies. It is
classified into three degrees according to the epithelial cells differentiation. The study
aimed to investigate the changes in BMP-2 expression according to the histological
degrees of the tumor.
Materials and methods : In the present study، BMP-2 expression was compared
immunohistochemically among oral squamous cell carcinoma in 27 cases (19 male+8
female) ranging between (22-74) years، mean age of (48) years. Patients have been divided
into 3 groups (each contain 9 case) according to the histological grade.
Results : By analyzing the statistical results, No significant correlation between
BMP-2 expression and the histological grad was observed. The severity of expression was
not affected by the tumour degree. Changes in membranous localization and intense
cytoplasmic staining were also not observed.
Conclusion : according to this study BMP-2 does not represent a prognostic marker
for the histological grade of oral squamous cell carcinoma.
We will first introduce the basic ingredient of Fourier methods in
section 1, then we will do some analysis on the Fourier
approximation, in the last section, we will apply the Fourier
method to solve some ODEs . we will write Matlab code for
num
erical result .
Stem cells have unique capability to differentiate into many cell types that can
normally replace the loss in some cells of the body due to tissue injury. Umbilical cord blood (UCB) and
umbilical cord (UC) are the two main sources for hematopoietic
stem cells (HSCs) and mesenchymal stem
cells (MSCs), respectively, which constitutes the basis for stem cell banks that have been established
worldwide and very recently in Syria. Research in our region has mainly focused on cell storage and
freezing protocols, and only few studies were conducted to prove the ability of the stored cells to
differentiate into their destined lineages. This study aimed to test the potential of cryopreserved MSCs
isolated from an umbilical cord taken from new delivery at Maternity University Hospital in Damascus, to
differentiate into various types of cells in response to growth and induction factors specific to cell lineages.
This research aims at establishing
and testing protocols for isolation, in vitro proliferation, phenotyping, and
differentiation of MSCs embedded in umbilical cord tissues of Syrian
newborns.
MSCs were isolated from two caesarian births depending
on their
adherence characteristic on plastic surfaces, and cells were cultured in MSC
medium for their growth and proliferation. Cell phenotyping was performed by
flow cytometry using fluorescent monoclonal antibodies specific to MSCs’
surface markers. Cultured cells were passed several times and a portion of
these cells was cryopreserved in liquid nitrogen, and cell viability was assessed.
Differentiation of these MSCs into adipocytes was conducted using culture
medium Indomethacin and hydrocortisone.
The aim of this study is to use the measured values of the magnetic
susceptibility in the classification of the basaltic rocks and their different
differentiation degrees as an additional discrimination factor to the
geochemical analyses, which we
re applied on the basalts of southern and southeastern
Syria. So the magnetic susceptibility of ٢٠٤ specimens sampled from all
the ٧ basaltic groups in Qasr Shbeeka area in addition to ٦٢ specimens
sampled from three groups from outside the studied area were measured. This
led to the determination of all the magnetic susceptibility ranges, their mean
values and their standard deviation of the basaltic rocks in the area.
