Adverse Drug Event (ADE) extraction models can rapidly examine large collections of social media texts, detecting mentions of drug-related adverse reactions and trigger medical investigations. However, despite the recent advances in NLP, it is curren
tly unknown if such models are robust in face of negation, which is pervasive across language varieties. In this paper we evaluate three state-of-the-art systems, showing their fragility against negation, and then we introduce two possible strategies to increase the robustness of these models: a pipeline approach, relying on a specific component for negation detection; an augmentation of an ADE extraction dataset to artificially create negated samples and further train the models. We show that both strategies bring significant increases in performance, lowering the number of spurious entities predicted by the models. Our dataset and code will be publicly released to encourage research on the topic.
Many T2D use CAO as a laxative. We did not find sufficient research to explain CAO's potential effect on the levels of HbA1c in T2D patients. This study will study this effect. Rats (n=80) were divided into eight groups (n=10). Five groups (n=50) wer
e injected with streptozotocin intravenously to induce T2D. One group was given CAO with empagliflozin, and the second was assigned CAO only daily. The third was assigned CAO every two days, with empagliflozin, which was given daily. A fourth was assigned CAO alone daily. Also, the fifth was given empagliflozin alone. In the healthy groups, one group was given CAO, and the other was given empagliflozin. Also, the last healthy group was not assigned any drug. CAO's result on HbA1c in healthy rats was noted to decrease when delivered alone for eight weeks. HbA1c of the diabetic groups showed no significant difference (P-value<0.05) when comparing the rats given CAO with empagliflozin, and the rats were given CAO only. There was also no noticeable effect among the groups of rats given CAO daily and every two days. This study explains that CAO does not lead to a significant difference in HbA1c levels in diabetic rats, even it did for healthy rats, and if given alone, CAO could affect HbA1c levels if given over a long period. Also, CAO has a noticeable impact on experimental rats that co-administered Empagliflozin on HbA1c levels, and that Empagliflozin effect is not significantly affected if taken with CAO.
Medication errors are the most common medical errors, which may cause complications in
patients, nursing staff are the first one who deal with these errors, so the current descriptive
study aim to identify the factors leading to the Medication erro
rs at Tishreen University
Hospital from the Point of view of 48 nurses working at internal department by using
suitable tool for the study object. The study found that the most important factors that lead
to medication errors are the inability to read instructions because of the poor doctor's line,
Inability to interpret physician order correctly, the Heavy workload and fatigue, tension
and Lack of sleep, and interruption and Distract during Work by someone else,
inconvenience during work. The study recommended to establishment of educational
courses for the nursing staff in the hospital on the subject of the factors causing the
Medication errors and ways to prevent their effects, to inform the doctors and nurses
working at hospital about the results of this study, put these results in the consideration of
policy makers of the hospital to develop rules and strategies that exceed the impact of these
factors to include Patient safety, and similar studies in several hospitals to ascertain the
results of the study.
Improving the solubility rate of fursemide in biological media by using self-emulsifying systems and preparing them in the form of tablets in order to improve its bioavailability and reduce variations in treatment between individuals. Fursemide is classified as a fourth-class drug according to the biopharmaceutical classification due to its limited solubility and permeability.
Improving the solubility rate of fursemide in biological media by using self-emulsifying systems and preparing them in the form of tablets in order to improve its bioavailability and reduce variations in treatment between individuals. Fursemide is classified as a fourth-class drug according to the biopharmaceutical classification due to its limited solubility and permeability.
Emergency cases can occur anytime, anywhere and to anyone. Such situations
are somewhat more likely to occur within the confines of the dental office due to the increased level of
stress which is so often present. This study aims to determine the readiness and the interest of dental clinic
for the management of such cases.
