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Register a new userعلاقة مستويات التعبير الجيني لمورثتي DNMT3A و DNMT3B المسؤولتين عن مثيلة الدنا بإنذار المرض لدى عينة من مرضى ابيضاض دم نقوي حاد سوريين في مشفى البيروني الجامعي
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Damascus University رسالة ماجستير
Publication date
2016
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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يعد الابيضاض النقوي الحاد أحد أكثر انواع الابيضاضات شيوعاً لدى البالغين وقد ازدادت معدلات الإصابة به والوفيات الناتجة عنه بشكل ملحوظ في السنوات الاخيرة
No English abstract
References used
Kubista , M , et al . The real-time Polymerase chain reaction .Mol Aspects Med 2006
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Gene regulation by microRNAs (miRNAs) is one of the most important regulatory
networks which control normal hematopoiesis. Disturbances in miRNAs levels lead to
proliferation diseases including leukemogenesis. MicroRNAs is a major topic of many
ca
ncer researches performed to discover noninvasive biomarkers used for diagnosis,
prognosis, and optimization of clinical decision.
This study, the first to be performed in Syria, aimed at monitoring miR-155 levels
compared to a normalizer gene RNU6-2 by quantitative reverse transcriptase -PCR (qRTPCR)
in a sample of newly diagnosed untreated AML patients at several hospitals in
Damascus in comparison with healthy controls. Changes in miR-155 gene expression
levels were calculated in patients and controls using the 2-ΔCt method.
The most important finding was the association of low and very high miR-155 levels
with poor prognosis reflected in failure to accomplish complete remission and high
mortality. In addition, high miR-155 levels were associated with M4 AML subtype,
although with large variance among patients. We hope our preliminary study pave the road
for many future research studies related to the applicability of microRNAs in supporting
diagnosis, predicting prognosis, and enhancing the personalized therapies which deal with
patients as individual cases.
In the present study, we measured DNMT3A levels, the
methylation enzyme, in blood samples from Syrian AML patients
and normal individuals using real-time quantitative polymerase
chain reaction, in order to determine the roles of DNMT3A in the
development of leukemia.
Radiocontrast-induced nephropathy, is becoming increasingly common cause of
Acute kidney injury (AKI).The aim of the present prospective study was to find out the
incidence and outcome of CIN in patients undergoing coronary angiography. Over a one
year period [2014]. At al-Assad university Hospital-Syria. 54 patients , satisfied the criteria
for entering into the study.Median age was 56 yr All were followed for development of
acute renal failure. The incidence was found to be 22.2 % .12 developed some evidence of
acute renal failure .4 required dialysis acutely. There were 2 deaths. and pre existing renal
impairment is one of the risk factors for developing contrast induced nephropathy.
Serum Creatinine should be measured routinely in all patients
who are scheduled form coronary angiography.
Mitochondria are the major organelles in eukaryotic cells primarily responsible for many cellular functions. Recently, a decrease or increase in mtDNA copy number has been increasingly recognized in human cancers.
دور بعض الكيموكينات في الربو القصبي لدى مرضى سوريين : الربو اضطراب التهابي مزمن يرتبط مع التأتب وفرط فعالية القصبات
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