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Comparison of efficacy of doxycyclin vs. systemic isotretinoin in the treatment of Rosacea

مقارنة فعالية علاج وردية الوجه بالإيزوتريتينوئين الجهازي مع الدوكسيسيكلين

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 Publication date 2018
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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The aim of this study is to compare the efficacy of doxycyclin vs.systemic isotretinoin in the treatment the second and third forms of rosacea, 50 patients aged between 22 - 61 years of patients who had a second type II and type III of Rosecea with at least eight inflammatory lesions were divided into 2 groups of 25, The first was treated with isotretinoin and the other with doxycycline. The effectiveness of both treatments was compared, in addition, the side effects between the two treatments. Results: In general, there were no significant difference between the 2 drugs in The number of Papules and pustules, the severity of the erythema and Rhinophyma. In both groups there was a clear relation between the treatment and DLQI . For side effects, The results shown that 18 patients in the group of isotretinoin therapy had side effects and no side effects were observed for patients treated with doxycycline. Conclusion: The study concluded that isotretinoin therapy had similar efficacy to doxycycline therapy.


Artificial intelligence review:
Research summary
تهدف هذه الدراسة إلى مقارنة فعالية علاج وردية الوجه من النمطين الثاني والثالث باستخدام الإيزوتريتينوئين الجهازي والدوكسيسيكلين. أجريت الدراسة على 50 مريضاً تتراوح أعمارهم بين 22 و61 سنة، وتم تقسيمهم إلى مجموعتين: الأولى عولجت بالإيزوتريتينوئين والثانية بالدوكسيسيكلين. تم تقييم فعالية العلاجين من خلال عدد الحطاطات والبثرات، شدة الحمامى، ودرجات فيمة الأنف. أظهرت النتائج عدم وجود فروق إحصائية هامة بين العلاجين من حيث الفعالية، ولكن ظهرت آثار جانبية أكثر عند المرضى المعالجين بالإيزوتريتينوئين مقارنة بالدوكسيسيكلين. توصلت الدراسة إلى أن كلا العلاجين لهما تأثير مشابه على نوعية حياة المرضى، مع توصية بإجراء دراسات مستقبلية على مجموعات أكبر من المرضى.
Critical review
دراسة نقدية: على الرغم من أن الدراسة قدمت نتائج مهمة حول فعالية العلاجين، إلا أن حجم العينة كان صغيراً نسبياً (50 مريضاً فقط)، مما قد يؤثر على تعميم النتائج. بالإضافة إلى ذلك، لم تتناول الدراسة تأثير العوامل الأخرى مثل نمط الحياة والتغذية على فعالية العلاجين. كما أن فترة المتابعة كانت قصيرة نسبياً (3 أشهر)، مما يجعل من الصعب تقييم الآثار الطويلة الأمد للعلاجين. يوصى بإجراء دراسات مستقبلية تشمل عينات أكبر وفترات متابعة أطول لتأكيد النتائج.
Questions related to the research
  1. ما هو الهدف الرئيسي من الدراسة؟

    الهدف الرئيسي من الدراسة هو مقارنة فعالية علاج وردية الوجه من النمطين الثاني والثالث باستخدام الإيزوتريتينوئين الجهازي والدوكسيسيكلين.

  2. ما هي النتائج الرئيسية التي توصلت إليها الدراسة؟

    توصلت الدراسة إلى أن كلا العلاجين لهما فعالية مشابهة في علاج وردية الوجه، ولكن الإيزوتريتينوئين يسبب آثار جانبية أكثر مقارنة بالدوكسيسيكلين.

  3. ما هي التوصيات التي قدمتها الدراسة؟

    أوصت الدراسة بإجراء دراسات على مجموعات أكبر من المرضى لتأكيد النتائج، ومقارنة فعالية الأدوية الجهازية مع الأدوية الموضعية المستخدمة لعلاج الوردية.

  4. هل كانت هناك فروق إحصائية هامة بين العلاجين من حيث الفعالية؟

    لا، لم تكن هناك فروق إحصائية هامة بين العلاجين من حيث الفعالية.


References used
VAN ZUUREN et al systematic review ofrosacea treatments. J Am Acad dermatol 2007 :56:107_115
GALLO RL et al, Standard classification pathophysiology of rosacea: The 2017 , update by the National Rosacea Society , Expert Committee.JAAD . 2018 Jan;78(1):148- 155
FDA OKs New Cream for Facial Facial in Rosacea in Adults. Medscape - Jan 19, 2017
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