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Investigation of Congenital Hypothyroidism in Newborns and Children at University Children's Hospital in Damascus

استقصاء الإصابة بقصور الدرق الخلقي لدى الولدان و الأطفال في مستشفى الأطفال الجامعي في دمشق

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 Publication date 2018
  fields Pharmacy
and research's language is العربية
 Created by Shamra Editor




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The aim of this study is to collect more information about Congenital hypothyroidism (CH) in Syria due to it being one of the most common causes of preventable mental retardation if detected at early stage and treatment is preventable, and to the absence of any published statistics regarding it in our country, and to emphasize on the necessity of applying a mandatory newborn screening program for early diagnosis of congenital hypothyroidism to improvement of child’s life, by investigating the adequacy of the clinical determination the physician's experience to get an early diagnosis.


Artificial intelligence review:
Research summary
تهدف هذه الدراسة إلى استقصاء الإصابة بقصور الغدة الدرقية الخلقي (CH) لدى الولدان والأطفال في مستشفى الأطفال الجامعي في دمشق. يعتبر قصور الغدة الدرقية الخلقي أحد الأسباب الشائعة للتخلف العقلي الذي يمكن الوقاية منه إذا تم الكشف عنه ومعالجته مبكرًا. شملت الدراسة 16 طفلًا مشتبه بإصابتهم بقصور الغدة الدرقية الخلقي بناءً على الأعراض السريرية أو التاريخ العائلي أو الوزن المنخفض أو الولادة المبكرة. تم تأكيد الإصابة في ثلاث حالات فقط من خلال قياس مستويات TSH و fT4 في الدم. أظهرت الدراسة ضرورة إنشاء برنامج تحري وليدي إلزامي للكشف المبكر عن هذا الاضطراب وتحسين حياة الأطفال المصابين. كما أكدت الدراسة على أهمية رفع مستوى الوعي لدى الأطباء والمجتمع حول هذا المرض لتجنب التأخر في التشخيص والمعالجة.
Critical review
دراسة نقدية: على الرغم من أهمية هذه الدراسة في تسليط الضوء على مشكلة صحية خطيرة، إلا أن هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة صغير جدًا ولا يمكن تعميم النتائج على نطاق واسع. ثانيًا، لم يتم التطرق بشكل كافٍ إلى العوامل البيئية والاجتماعية التي قد تؤثر على انتشار المرض. ثالثًا، كان من الممكن أن تكون الدراسة أكثر شمولية إذا تضمنت مقارنة مع بيانات من دول أخرى أو مناطق أخرى داخل سوريا. وأخيرًا، يجب أن تكون هناك توصيات واضحة ومحددة حول كيفية تنفيذ برنامج التحري الوليدي بشكل فعال في سوريا.
Questions related to the research
  1. ما هو الهدف الرئيسي من هذه الدراسة؟

    الهدف الرئيسي هو جمع معلومات أكثر عن قصور الغدة الدرقية الخلقي في سوريا والتأكيد على ضرورة تطبيق برنامج تحري وليدي إلزامي للتشخيص المبكر لهذا الاضطراب.

  2. كم عدد الأطفال الذين شملتهم الدراسة وتم تأكيد إصابتهم بقصور الدرق الخلقي؟

    شملت الدراسة 16 طفلًا، وتم تأكيد الإصابة بقصور الدرق الخلقي في ثلاث حالات فقط.

  3. ما هي الطرق المستخدمة لتأكيد الإصابة بقصور الدرق الخلقي في هذه الدراسة؟

    تم تأكيد الإصابة من خلال أخذ عينات دم كامل ومعايرة مستويات TSH و fT4.

  4. ما هي التوصيات التي خرجت بها الدراسة؟

    أوصت الدراسة بضرورة إنشاء برنامج تحري وليدي إلزامي للكشف المبكر عن قصور الدرق الخلقي ورفع مستوى الوعي لدى الأطباء والمجتمع حول هذا المرض.


References used
LAFRANCHI, S. and RASTOGI, M., 2010, Congenital Hypothyroidism, Orphanet J Rare Dis., vol. 5, no. 17, 22
VALIZADEH, M., MAZLOOMZADEH, S., NIKSIRAT, A., SHAJARI, Z., 2011, High Incidence and Recall Rate of Congenital Hypothyroidism in Zanjan Province, a Health Problem or a Study Challenge?. Int J Endocrinol Metab., vol. 9, no. 4, 338-342
PEZZUTI, IL., LIMA, PP., DIAS, VM., 2009, Congenital hypothyroidism: the clinical profile of affected newborns identified by the Newborn Screening Program of the State of Minas Gerais, Brazil. J Pediatr (Rio J), vol 85, no. 1, 72-79
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