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Register a new userMicrobiological Quality control of some herbal medicines
مراقبة جودة بعض المستحضرات الدوائية العشبية من الناحية الجرثومية
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Aِl-Baath University ورقة بحثية
Publication date
2016
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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تعتبر نقاوة المستحضرات الصيدلانية من الناحية الجرثومية من معايير الجودة الواجب التقصي عنها. تُعد المستحضرات الدوائية العشبية من الأشكال ذات الخصوصية من حيث أن المواد الأولية التي تدخل في تركيبها هي من مصدر طبيعي، و هذا يعني أنيا عرضة لتلوث جرثومي محتمل. يعرف دستور الأدوية المستحضر العشبي بأنه النبات أو الفطر fungi أو الأشنة الكامل أو المجزأ أو أجزاء منه في شكله غير المصنع unprocessed state و غالباٌ بشكله الجاف.
The microbiological limits are considered to be one of the quality criteria that affect pharmaceutical. Herbal drug medicine is of some specialty since their raw material contains a high bioburden. According to pharmacopoeia, Herbal drugs are mainly whole, fragmented or cut, plants, parts of plants, algae, fungi, lichen in an unprocessed state, usually in dried form but sometimes fresh.
References used
aya Bir Karmacharya (2012). Good Manufacturing Practices (GMP) for Medicinal Products, Promising Pharmaceuticals, Dr. Purusotam Basnet (Ed.), ISBN: 978-953-51-0631-9, InTech
(Forty-fourth report of the WHO Expert Committee on specifications for pharmaceutical preparations 2010. (WHO technical report series; no. 957
(Forty-fifth report of the WHO Expert Committee on specifications for pharmaceutical preparations 2011. (WHO technical report series ; no. 961
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The red meat is one of the main group of food due to their high
content of protein , mineral salts , vitamins . But the high content of
humidity and its pH value that is suitable to growth of most
microorganisms make it subject to spoilage .
In t
his study different samples of commercial meat which were
taken from market in Homs , were valuated by microbial analysis
and that were done for fresh samples , and after one month of frozen
storage in home .
The study indicated that the most of commercial red meat , were
unacceptable to human consumer because the total number of
Aerobic Bacteria , Listereia, Staphylococcus Aureus , Salmonella ,
E. coli , were unacceptable to Syrian Arab Organization for
Standardization that may be due to disases of animale or the
contamination that was happened during dealing from farm to
consumer .
The aim of this study was to control the content of some commercial products containing amino acid (Arginine) available in the local market in addition to other products containing creatine and protein. Three methods were used for quantitative determ
ination of amino acids Kjeldahl method depending on the total content of nitrogen, assay by the visible radiation using Spectrophotometer after ninhydrin derivatization and high performance liquid chromatography with pre-column O-phtadelaldehyde derivatization using fluorescence detector. There were no significant differences in the results obtained by the three used methods. The results revealed that dietary supplements containing creatine and protein were conform to the European pharmacopoeia specifications, regarding products containing arginine used as medication and locally manufactured, they were conform to pharmacopoeia specifications while the illegal dietary supplement containing arginine were not conform.
The history of medicine using medicinal plants goes back thousands of years, and according to the reports of the World Health Organization, many of the world's people mainly use the plant to treat many diseases, and one of the plants that is famous for its widespread use is the leaves of Ginkgo biloba.
Benzoic acid is extensively used in the preservation of food products for maintaining
quality and extending shelf life by inhibiting mould and bacteria growth.
Some previous studies have demonstrated that consumption of excessive amounts of
benzoi
c acid could be a health hazard.
The aim of this study was to detect the presence of benzoic acid and its salts in
some commercial children food like potatochips that labeled "Free of Preservatives" .
Twenty seven samples of potatochips purchased from three different local products
were analyzed for the presence of benzoic acid.
The results revealed the presence of benzoic acid in nine samples and its
concentration was between 100.34-188.65mg/kg.
We have concluded also that TLC is a very convenient method for the
detection of benzoic acid in food products .
Laboratory experiments were conducted to study the effect of the aqueou extract of the
vegetative parts of the Euphorbia paralias at different concentrations (2%,4%,8%) in seed
germination and seeding growth of the Lepidium sativum, Lactuca sativa
and
Portulaca oleracea. The results indicated increase in germination ratio of Portulaca
oleracea. up to 7%. while the effect of the extract was not evident in the germination of the
seeds of Lepidium sativum, and decreased the germination ratio of Lactuca sativa
seeds by 35.9% at the concentration of 8%.In contrast, the extracts stimulated the length of
the stalks of Portulaca oleracea , Lepidium sativum and Lactuca sativa plants at all
used concentrations used. The highest rate of stimulated stalks legnth of Lepidium
sativum at 2% was 58.2%. inhibitory effect of water extract observed for root length of
Portulaca oleracea and Lactuca sativa plants at 2% , and stimulation effect pour
Lepidium sativum, The effect became evident at the concentrations of 4% and 8% for the
three plants.
The most sensitive and affected plants was Portulaca oleracea, where the length of the
root decreased by 53.38% at the concentration of 4% and by 72% at the concentration of
8% ,while the length of the root Lepidium sativum and Lactuca sativa decreased by
25.82% and 34.95% was decreased for 4% and 8%respectively.
The results suggested that this weed may affect seedling growth, due to inhibitory or
stimulatory effect of Allelochemicals , which present in water extract of this weed . and
may used as potential Bioherbicide after further experiments.
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