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Register a new userEvaluation the role of protein KIM-1in the kidney injuries
تقييم دور بروتين KIM-1 في الأذيات الكلوية
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Kidney Injury Molecule-1) KIM-1): هو عبارة عن بروتين سكري عبر غشائي يعبر عنه بمستويات عالية في خلايا الأنابيب الكلوية القريبة بعد حدوث الأذية الكلوية، يتألف من مجال خارج خلوي يحوي مجالا مشابهاً لIg يتألف من 6 ثمالات سيستيئين بالإضافة إلى موقعين لإضافة السكرياتGlycosylation و مجال عبر غشائي و مجال ستوبلاسمي و موقع لفسفرة التيروزين مصان بين الأنواع.
Kidney Injury Molecule-1 (KIM-1) is a type 1 transmembrane glycoprotein. KIM-1 is highly up regulated in proximal tubular cells following kidney injury. It consists of an extracellular portion, a novel 6-cysteine immunoglobulin-like domain, 2 N-glycosylation sites, also contains one transmembrane domain and a short cytoplasmic domain with a conservative tyrosine phosphorylation site.
References used
Devarajan P. Neutrophil gelatinase-associated lipocalin: a promisingbiomarker for human acute kidney injury, Biomark Med, 4(2): 265–280, 2010
(Kumar P, Clark M. Renal disease, In: Clinical Medicine. 6th Ed, Saunders Elsevier, pp:659-665, (2005
Ichimura T, Bonventre JV, Bailly V, Wei H, Hession CA, Cate RL, SanicolaM: Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem273: 4135–4142, 1998
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treated with arthroscopic debridement of the knee in the Tr
aumatology orthopedic service
in Alassad hospital in Lattakia in 2013 -2015.
Our objective through this small series was to show the interest of arthroscopic
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synovectomy, debridement and excision of fragments meniscal, cartilage or osteophyte.
The postoperative complications were marked by a single case of intra-articular
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The clinical results after a decline of 12 months were satisfactory.
The results depend on good pre-operative planning, and irreproachable technical
gesture.
The experience of operators and technologic advances in has extended its indication.
The possibility of using some agents used in traditional medicin .
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Materials and M
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