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Register a new userEffects of Cold and Emotional Stress on the Threshold of Algesia on Normal and the Adrenalectomized Rats
تأثير الكرب بالحرارة المنخفضة و الكرب الانفعالي في عتبة فقدان الشعور بالألم عند الجرذان السليمة و الجرذان المستأصلة غددها الكظرية
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جرجس ديب( باحث )
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تعد هرمونات قشر الكظر من أهم مكونات الاستجابة غير النوعية للمتعضية الحية لمختلف المؤثرات المسببة للكرب بما في ذلك الكروب المحدثة لفقدان الشعور بالألم. يهتم هذا البحث بدراسة تأثير التعرض المتكرر للكرب بالحرارة المنخفضة (السباحة في المياه الباردة، ١٧ م، لمدة ١٠ دقائق) و الكرب الانفعالي (تقييد الحركة لمدة ١٠ دقائق) بمعدل ٦ جلسات يوميا و لمدة ستة أيام متتالية، في عتبة الشعور بالألم(اختبار الزمن الكامن لسحب الذيل Test of tail flick latency) عند جرذان السليمة Wistar و الجرذان المستأصلة غددها الكظرية، و ذلك بهدف تحديد دور المنظومات الوساطية في فقدان الشعور بالألم و علاقتها المحتملة بهرمونات قشر الكظر.
The adreno-cortical hormones ,are considered one of the most important parts of the nonspecific reaction of the organism to different stress effects including the stress induced analgesia . This paper is interested in the study of the effect of repeated cold stress(swimming in cold water ١٧ c for ten minutes) and the emotional stress (immobilization for ten minutes) for the average of six times daily for six days,(on the test of tail flick latency) in normal and adrenalectomized rats . The aim is to know the analgesic system and their probable relation wth the adreno-cortical hormones .
References used
Blusten J. E., Hornig O. & Bostwick – Poli , M. Role of contextual stemuli in tolerance to stress – induced analgesia. Pharmacol. Biochem. Behav
Blusten J. E, Cicolone I. & Bersh J. P. Evidence that adaptation to cold water swim – induced analgesia is a learned response. Physiology & Behavior
Bandar R. J., Kelly D.D, Spiaggia A. & Clusman M. Stress – induced analgesia, adaptation following chronic water swims. Bull. Psychol. Soc
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We had shown that the mechanism of analgesia induced by swimming
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e mechanism of analgesia induced by swimming stress in
both male and female Wistar rats and the possibility of its relation with sexual
hormones.
The male and female show an increase in the threshold of pain as result of
swimming stress (Swimming in the water during 3 minutes, with 16 C). The
analgesia in the females was more important compared with males. The
pretreatment with naloxone led to a partial inhibition of stress- induced
analgesia in both sexes, but in males it was more important.
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