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Register a new userThe sexual differences in the mechanism of analgesia induced by swimming stress in Wistar rats
الاختلافات الجنسية في آلية فقدان الشعور بالألم المحرض بالكرب السباحي عند جرذان Wistar
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Damascus University ورقة بحثية
Publication date
2004
fields
Biology
and research's language is
العربية
Authors
جرجس ديب( باحث )
Created by
Shamra Editor
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بينا في دراسات سابقة أن آلية فقدان الشعور بالألم المحرض بـالكرب الـسباحي لـدى ذكـور الجرذان مرتبطة بشدة الكرب و تم الكشف عن بعض جوانب علاقة هذه الآلية بهرمونات قشر الكظر. يهدف البحث الحالي إلى دراسة الاختلافات الجنسية في آلية فقدان الشعور بالألم المحرض بـالكرب السباحي لدى كل من ذكور و إناث الجرذان من سلالة (Wistar) و علاقتها المحتملة بالهرمونـات الجنسية. تبدي ذكور و إناث الجرذان السليمة إثر تعرضها للكرب السباحي (الـسباحة فـي ميـاه درجـة حرارتها 16 م لمدة 3 دقائق) ارتفاعا ملحوظا في عتبة الشعور بالألم. و لقد تميز فقدان الشعور بالألم لدى الإناث بكونه أكثر أهمية (أعلى) مقارنة مع الذكور. و لقد أدت المعالجة المسبقة بالنالوكـسون إلى حصار جزئي لفقدان الشعور بالألم (للتسكين) المحرض بالكرب السباحي لدى كلا الجنسين مـع كون الحصار أكثر أهمية لدى الذكور منه لدى الإناث.
We had shown that the mechanism of analgesia induced by swimming stress in Wistar males is closely related to stress, some of the relation to this mechanism with cortical hormones. The aims of this research is to study the sexual differences in the mechanism of analgesia induced by swimming stress in both male and female Wistar rats and the possibility of its relation with sexual hormones. The male and female show an increase in the threshold of pain as result of swimming stress (Swimming in the water during 3 minutes, with 16 C). The analgesia in the females was more important compared with males. The pretreatment with naloxone led to a partial inhibition of stress- induced analgesia in both sexes, but in males it was more important.
References used
Andersson, H.I., Ejlertsson, G., Leden, I., & Rosenberg, C. (1993). Chronic pain in a geographically defined general population: Studies of differences in age, gender, social class, and pain localization. Clinical Journal of Pain, 9, 174-182
Averbuch M,Katzper M. (2000). Asearch for sex differences in response to analgesia.Archives of internal medeicine, December 11, 160 (22): 3424-3428
Baron S. A, Gintzler A. R, (1984). Pregnancy-induced analgesia:Effects of adrenalectomy and glucocorticoid replacement. Brain Res, 12; 321(2):341-6
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بينا في دراسة سابقة أن فقدان الشعور بالألم المحرض بالكرب السباحي (السباحة في مياه باردة
١٧ مئوية لمدة ١٠ دقائق) مرتبط بآليات أفيونية و غير أفيونية الوساطة. يهدف البحث الحالي إلى دراسة
آلية فقدان الشعور بالألم (اختبار الزمن الكامن لسحب الذيل) المحرض
بالكرب السباحي الأقل وطأة
(السباحة في مياه باردة ١٧ مئوية لمدة ٤ دقائق) و التوصل إلى إثبات تجريبي إضافي يظهر علاقة
هرمونات قشر الكظر المحرضة بالكرب بهذه الآلية والكشف عن بعض جوانب هذه العلاقة عند جرذان Wistar.
The adreno-cortical hormones ,are considered one of the most important
parts of the nonspecific reaction of the organism to different stress effects
including the stress induced analgesia . This paper is interested in the study of
the effect of re
peated cold stress(swimming in cold water ١٧ c for ten minutes)
and the emotional stress (immobilization for ten minutes) for the average of six
times daily for six days,(on the test of tail flick latency) in normal and
adrenalectomized rats . The aim is to know the analgesic system and their
probable relation wth the adreno-cortical hormones .
The leptin, which is poly peptides hormones secreted mainly from fat cells,
is considered anorexigenic. Leptin inhibits appetite by causing chemical
signals after combining with its specific receptors in the hypothalamus area.
These signals can be
discovered by variation of the concentration of the
hypothalamus proteins P.STAT3 (Phospho Signal Transducer and
Activator of Transcription) P.MAPK( Phospho Mitogen-Activated Protein
Kinase), which can be inhibited by negative feedback of PTP1B( Phospho
Tyrosine Phosphatase 1 ) or SCSO3( Suppressor of Cytokine Signaling),
resulting in homeostatic and energetic regulation in the body. Moreover,
there are signals disorders cases, which lead to obesity in spite of increased
plasma level of leptin, which indicates to existence of leptin resistance.
Rat collagen II – induced arthritis is a model of chronic
inflammation induced by Mycobacterium butyricum and collagen II. It is
characterized by similar pathophysiological and pathobiochemical changes
as rheumatoid arthritis (RA) in humans. In th
e present study, the
biochemical and histopathological effects of vitamin E, allopurinol (Allo),
on RA of rats were investigated. The oxidative stress indices and
prostaglandin E were evaluated.
The increasing trends of urbanization and the rapid growth in the major cities, generated many problems
such as unemployment, poverty, slums, and deterioration in the level of supply of urban services. So an
urgent need arose for the establishment
of urban observatories under the Centre for Geographic
Information for the city ,hoping to achieve the best interest of the assembly, operation and analysis of data
and information in the areas of urban development and local working within the system of the Global
Urban Observatory and in the light of the Global Urban Indicators and Millennium Development Goals
for the suitability of the level of the city and harmony clearly with public strategies and the future vision
of the state as it was set in development plans and with the outline of the strategic urban planner for the
city.
The research aims to identify how to create an Urban Observatory and the achievement of its duties by
using his human, technical and development of urban and local indicators and adapt it with the character
and identity of the city and the work of the applications of statistical and spatial analyses using geographic
information systems that enable the planner and the decision maker to follow the urban development and
to identify the extent of improvement or deterioration in the economic, physical, environmental, and work
to achieve higher levels of urban development objectives.
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