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Register a new userThe effect of Rosuvastatin in the treatment of Rheumatoid Arthritis in rats
تأثير الروزوفاستاتين على التهاب المفاصل الروماتويدي المحدث عند الجرذان
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تم إجراء البحث على جرذان ويستر أحدث لديها المرض بواسطة حقن 0.1 مل من العامل المساعد التام في أخمص القدم اليمنى و في اليوم 14 من إحداث المرض أعطي الروزوفاستاتين بجرعتين 5 ملغ\كغ باليوم و 20 ملغ\كغ باليوم فمويا و ديكسا ميتازون 0.05 ملغ\كغ في اليوم حقنا عضليا و في اليوم 28 تم إجراء الدراسة النسيجية على المفاصل المدروسة.
The study has been done with Wister Rats have disease by 0.1 ml Complete Freund Adjuvent in right foot. At day 14 we gave Rosuvastatin (5- 20) mg/ kg PO and Dexamethazone 0.05 mg/kg IM until the day 28. At day 28 the joints have been studied hystologically.
References used
AARAVAK T, NATVIG JB. 2001. Cell-cell interactions in synovitis: antigen presenting cells and T cell interaction in rheumatoid arthritis (Review). Arthritis Res P:13-17
BARTOK B, FIRESTEIN GS 2010. Fibroblast-like synoviocytes: key effector cell in rheumatoid arthritis (Review). Immunol Rev VOL233, 233-255
BENOIST C, MATHIS D 2000. A revival of the B cell paradigm for rheumatoid arthritis pathogenesis? (Review). Arthritis Res VOL 2, 90-94
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Rat collagen II – induced arthritis is a model of chronic
inflammation induced by Mycobacterium butyricum and collagen II. It is
characterized by similar pathophysiological and pathobiochemical changes
as rheumatoid arthritis (RA) in humans. In th
e present study, the
biochemical and histopathological effects of vitamin E, allopurinol (Allo),
on RA of rats were investigated. The oxidative stress indices and
prostaglandin E were evaluated.
Background& Objective: This research is carried out to investigate the Anti-inflammatory activity of the alcoholic extract of flower buds of Crataegus laevigata in experimentally-induced arthritis in rats.
Materials & Methods: the inflammation was i
nduced experimentally by Carrageenan, the standard material that causes non-immune acute inflammation. The size of edema was measured before and after the inducing the inflammation, in control group as well as in group treated by extract and by Diclofenac.
The measurements persist until the 4th hour following the injection of Carrageenan. In another set of experiment, the important biomarker, TNF-α, was calibrated in inflammation-induced groups of rats that received extract or Diclofenac and compared with control.
Results: The extract significantly reduced the size of edema compared with control and this effect was not less than that of Diclofenac, the standard anti-inflammatory drug. Indeed, the extract lowered the values of TNF-α.
Conclusion: The Crataegus laevigata has clear anti-inflammatony effect , but it should be further investigated.
This Study was designed to evaluate the effects of Aloe vacillans leaves juice
on carbon tetrachloride CCl4- induced hepatotoxicity in rats.
Hepatotoxicity was induced in rats by intraperitoneal (i.p) injection of CCl4 (1ml/kg) of body weight every
72h during ethanolic extract of Aloe vacillans
leaves were administrated at dose 250 mg/kg and 500 mg/kg of body weight
pass orally (p.o) daily for 14 days.
Twenty-four hours post-CCl4 treatment, blood samples were withdrawn
through retro orbital sinus.The hepatotoxicity and its prevention was assessed
by serum parameters like alanine aminotransferase (ALT), aspartate
aminotransferase (AST), total protein (T.P) and albumin (ALB).
the sample consisted of 36 patients who were admitted in alassad and tishreen
hospital between 2013-2016 with bacterial arthritis proved by clinical,radiological and
laboratory methods. They went uder surgical intervention ,during it,a continuous i
rrigation
system was accomplished according to designed plan. The irrigation period was 12 days
(mean) with mean hospitalization period 12 days. Irrigation fluid was considered regarding
to culture and susceptibility results in addition to antibiotic qualities .Results were
collected depending on joint functional activitiy return regarding to capacity,bearing and
stability(after a month-3 months- year),as well as natural laboratory and vlinical features
return .we used the criteria healing (irrigation handout). The joint functional activity
returned after a month in (70% mean) ,after 3 months in (77% mean), after a year in (89%
mean).while the clinical infection signs fell back after a week in (85% mean) ,after a
month in (92% mean), after 3 months in ( 97%). The laboratory signs fell back after a
month in (91% mean), after 3 months in (97% mean). A comparing was achieved between
these results and irrigation period ,hospitalization period by using CHI² test . The use of
continuous irrigation system in treatment of bacterial arthritis once it is diagnosed (in
regard to designed plan, irrigation fluid qualities and the host condition) improves the joint
functional activity and reduces hospitalization period so that ,it lessens economic load and
accelerates the return professional activity.
This study was conducted on twenty white rats were distributed into five
groups and injected over a month and a half at different doses (ranging
from 150 - 950 mg / kg) of cimetidine.
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