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Register a new userEffect of γ Irradiation on the Odontogenesis of Mouse Embryos
تأثير التشعيع بأشعة غاما في تكوين الأسنان بجنين الفأر
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تم تشعيع أجنة الفأر في الرحم بأشعة غاما بالجرعات ٦ ،٤ ،٢ ،٠ غري في أحد أيام الحمل ١٠ ١٨ ،١٦ ،١٤ ،١٢ . ثم أُجريت الدراسة النسيجية لبداءات الأضراس السفلية الأولى في الأجنة بعد التشعيع ب ٨ ،٦ ،٤ ،٢ ، أيام، لتحري تأثير التشعيع في المراحل المختلفة لتكوين هذه الضرس.
Mice embryos were irradiated in utero by gamma rays (٠،٢،٤،٦ Gy) at ١٠،١٢،١٤،١٦،١٨ days of gestation. Histological study was carried out on the first premandibular molar after ٢،٤،٦،٨ days of irradiation, to investigate the effect of irradiation on different stages of molar development.
References used
Baba T., Terashima T., Oida S., Sasakis. (١٩٩٦)-Determination of enamel protein synthesized by recombined mouse molar tooth germs in organ cultlre. Arch. Oral Biol., ٤١(٢) ٢١٥-٢١٩
Baskar R. Uma Devi P. (١٩٩٣)-Effect of prenatal Gamma irradiation on the different gestation days on mouse. Bulliten Radiat. Protection. ١٦ (١ - ٢) ١٣٢-١٣٤
Bernhard E.J., Maity A., Muschel R.J. (١٩٩٥)-Effects of ionizing radiation on cell cycle progression . Radial Environ Biophys. ٣٤, ٧٩-٨٣
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This study involved the irradiation of mouse embryos at different stages of
pregnancy, using dose of ٤ Gy γ-radiation, at ١٠, ١٢, ١٤ and ١٦ days of
pregnancy. Pregnant mice were killed after ٢, ٤ and ٦ days post irradiation.
Embryo’s heads were is
olated and serial cross sections were made to
investigate the effect of irradiation on the different components of the eye at
different periods of eye organogenesis.
It was proved from this study that irradiation causes microphtalmia and
decrease in the growth of lens, retina and corneal stroma, as well severe
disruption in its development and disfigurement in its hitogenesis. These
defects have shown great differences in their severity according to the age of
embryos at exposure and the number of days post irradiation.
Orange fruits are characterized at harvesting with physical and sensory
properties determine consumer acceptance and in order to identify these
characteristics and vulnerability storage and irradiation conditions, Valancia
orange fruits were subje
cted to gamma irradiation at doses of 0.0, 0.5, 1.0, and
1.5 kGy using gamma 60Co irradiator facility. Fruits were kept in a refrigerator
for 18 weeks. Results indicated that physical and sensory properties of Valencia
orange fruits were affected by storage time and irradiation. The overall color
differences were increased and the firmness of fruits and skin were decreased.
The used doses of gamma irradiation increased the overall color differences of
fruit skin. Whereas the fruit firmness, and the sensory properties (aroma,
color, test and firmness) of irradiated Valencia orange fruits were decreased.
Pregnant mothers were irradiated by a single dose of gamma rays
(٠،٢،٤،٦ Gy, Cobalt ٦٠) in the days ١٠،١٢،١٤،١٦،١٨ of pregnancy. The
heads of the embryos’, and those of the neonates were taken at
consecutive intervals of irradiation, starting from
١٦ days of pregnancy
till ٣rd day after delivery. The effect of irradiation was investigated in the
development of the ٢nd and ٣rd lower molars on serial tissue sections,
within consecutive periods of their organogenesis. Irradiation led to
growth-deficiency in the ٢nd & ٣rd molars, and caused delay in their
development. This was observed in various degrees depending on the
dose, time of irradiation, and time after irradiation.
Increasing intramuscular doses of Methotrexate (25 mg / kg, 50 mg / kg,
100 mg / kg, 150 mg/ kg, 200 mg / kg, 250 mg / kg, 300 mg / kg) were tested on
Swiss strain Mouse by intramuscular injection. The reproductive potency was
evaluated by total s
perm count and movement of the left testis and it's
epididymis (15) days after injection. The weights of the latter of all tested
animals were registered.
The result indicate that Methotrexate, a Folate antagonist, is a negative
factor for sperm production in a dose related manner. It was evident that the
high doses (ex. Dose 200 mg / kg) lead to oligospermia. It was concluded that
Methotrexate inhibits the reproductive potency during spermatogenesis and
causes cytotoxicity in high doses. Further investigations are needed.
The aim of this research was to assess the physical, chemical،
microbiological and sensory characteristics of new made Qamar Al– stored for
six months and determine the effect of gamma rays on those characteristics.
Samples of Qamar Al–Din were su
bjected to sulfur fumigation and other
samples were left without sulfur fumigation and all samples were exposed to
four radiation doses (0, 1, 2 and 3 kilo Gray) and stored for 6 months at room
temperature (20° C). Results showed significant differences between sulfated
and non-sulfated samples in terms of pH, relative humidity, ash, total sugar،
viscosity, potassium, sodium, sulfur vitamin C and it was observed lower
microbial load. Results also showed that amount of vitamin C and viscosity was
significantly the highest in sulfated samples irradiated with 2 and 3 kilo Gray
and irradiation with a dose of 2 kilo Gray eliminated sufficiently the microbial
load. It was concluded that running this study is helpful to shed the light on the
importance of such these treatments especially that this traditional product
concerns large number of consumers and is exported to different countries in
the world.
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