The research was conducted on 60 patients, checking in the Department of Obstetrics
and Gynecology at the Assad University Hospital in Latakia, complaining of infertility(an
initial or secondary) between2011-2013
A satisfactory detailed story of t
he couple was taken with extra focus on the clinical
symptoms of polycysticovary of the wife (obesity, hirsutism, irregular menstruation,
infertility) and overlooking other feminine or masculine causes of infertility. In addition to
the calibration of Fsh, Lh, free testosterone, and ultrasound imaging of the uterus and
ovaries,
a perforation was performed on the ovaries by laparoscopic surgery. Patients were
checked for a year. This check up showed healthy pregnancy in 27 patients by 45%, but
this didn't work for 31 patients by 51.66%. In addition, 2 cases of abortion3.33% were
reported. . The study showed that age, duration of infertility and the rate of LH had an
effect on the success of the laparoscopic ovarian drilling process with patients of
Polycystic ovary.
Increasing intramuscular doses of Methotrexate (25 mg / kg, 50 mg / kg,
100 mg / kg, 150 mg/ kg, 200 mg / kg, 250 mg / kg, 300 mg / kg) were tested on
Swiss strain Mouse by intramuscular injection. The reproductive potency was
evaluated by total s
perm count and movement of the left testis and it's
epididymis (15) days after injection. The weights of the latter of all tested
animals were registered.
The result indicate that Methotrexate, a Folate antagonist, is a negative
factor for sperm production in a dose related manner. It was evident that the
high doses (ex. Dose 200 mg / kg) lead to oligospermia. It was concluded that
Methotrexate inhibits the reproductive potency during spermatogenesis and
causes cytotoxicity in high doses. Further investigations are needed.
The study was applied on 168 patients with primary infertility diagnosed endoscopically with documented AMH ovarian stock titre. It was found that most of these patients had a deficiency in the ovarian stock AMH. The aim of the study is to determine
the cause of the lack of ovarian reserve AMH, with the aim of taking into account that patients who are late in diagnosis have low ovarian inventory and make the decision for a tube child be late. After 7 months of laparoscopic surgical treatment, the values of AMH in the ovarian stock reached 1.87ng/mm, i.e. a decrease of 26.6% on average, and this decrease was 34.67% in the case of bilateral endometriosis, and 22.33% in the case of unilateral endometriosis. Age was noted as an independent prognostic factor for low AMH and initial AMH titer. The underlying cause of the positive association could be as the increase in the ovarian endothelium increases its toxicity to the ovarian stock and thus the PRIOMDIAL research can contribute and thus increase the AMH levels.
