Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userA new Spectrophotometric Method for the Determination of Lisinopril in Bulk and Tablets after Derivatization with 4- Nitrobenzene Diazonium Tetra Fluoro Borate
طريقة ضوئية جديدة لمعايرة الليزينوبريل بوصفها مادة أولية و في المضغوطات و ذلك بعد الاشتقاق بمادة 4 -نيتروبنزن ثنائي الأزو رباعي فلوربورات
937
0 7
0
(
0
)
Added by
Damascus University ورقة بحثية
Publication date
2006
fields
Pharmacy
and research's language is
العربية
Authors
جمعه الزهوري( باحث )
Created by
Shamra Editor
Ask ChatGPT about the research
طُورتْ طريقة تحليلية لونية ضوئية جديدة لمعايرة الليزينوبريل بوصفها مادة أوليـة Bulk و في شكلها الصيدلاني مضغوطات. تعتمد الطريقة على تفاعل اشتقاق كيميائي بين المركب و مادة 4 -نيتربنزن ثنائي أزونيـوم رباعي فلور بورات بوسط لا مائي حيث ينتج لوناً يعطي طولَ موجة و امتـصاصاً أعظميـاً عند 8.393 نم و قد كانت العلاقة ما بين الامتصاص و التركيز خطية عند هذه الموجة ضـمن المجال 5 – 50 ميكروغراماً / مل . طبقت هذه الطريقة لمعايرة الليزينوبريل في المضغوطات و قد كانت النسبة المئوية للمردود 98 ± %4.2 و قد كانت النتائج التي حصلنا عليها متوافقة مع تلك التي حصلنا عليها إحصائياً باستخدام تقانة الاستشراب السائل عالي الأداء الدستورية .
A new colorimetric analytical method was developed for determination of Lisinopril in bulk and tablets . The method is depended on derivatization chemical reaction between Lisinopril and 4- nitrobenzene diazonium tetra fluoro borate in non aqueous medium to give color derivatives with max. absorption at 293.8 nm . The resulting color was measured spectrophotometrically . The absorbance concentration plots were recti linear over the range 5-50 μg /ml. The method applied for determination the Lisinopril in Tablet, The percentage recoveries was 98% ± 2.4. The results obtained were in accordance with those found using the HPLC standard method in Pharmacopoeia .
References used
Aktas ES,Ersoy L, and Sagirli , O . A new Spectroflurimetric method for the determination of lisinopril in Tablets . IL Farmaco, 2003 (58) 165-168
Bonazzi D, Gotti R. , Andrisann , V. and Cavrini , V. Analysis of ACE inhibitors in pharmaceutical dosage forms by derivative UV-Spectroscopy and liquid chromatography ( HPLC). J.Pharm.Biomed Anal. 1997 (16) 431-438
Cascon AR,Cuadrado A,Solinis MA, Hernande RM , Ramires E, Datman R and Pedraz,H
rate research
Read More
New, accurate, sensitive and reliable kinetic spectrophotometric
method for the assay of fluvastatin sodium (FVS) in pure form and
capsules has been developed. The method involves the oxidative
coupling reaction of FVS with 3-methyl-2-benzothiazolinone hydrazone
hydrochloride monohydrate (MBTH) in the presence of Ce(IV) in an
acidic medium to form colored product with lambdamax at 615 nm.
In this research two analytical methods were developed for the determination of Azelastin as raw material and in Nasal Spray formulation.
The first method was spectrophotometric while the other used the technic of HPLC The first method based on meas
uring the absorbance at λmax 284 nm .
The relationship between the absorbance and the concentration is rectilinear over the range 0.001 – 0.008 g %.
The proposed spectrophotometric method was successfully applied to the determination of Azelastin in nasal spray.
The percentage recoveries were 99.378±1 (10 duplicate readings)1
No interference was noticed from co-formulated drugs.
For the absorbance at λmax the obtained results were in good agreement with which obtained by the Pharmacopeia method.
The substance gave a good separation while the retention time was 1.467 min.
Natural Language Processing offers new insights into language data across almost all disciplines and domains, and allows us to corroborate and/or challenge existing knowledge. The primary hurdles to widening participation in and use of these new rese
arch tools are, first, a lack of coding skills in students across K-16, and in the population at large, and second, a lack of knowledge of how NLP-methods can be used to answer questions of disciplinary interest outside of linguistics and/or computer science. To broaden participation in NLP and improve NLP-literacy, we introduced a new tool web-based tool called Natural Language Processing 4 All (NLP4All). The intended purpose of NLP4All is to help teachers facilitate learning with and about NLP, by providing easy-to-use interfaces to NLP-methods, data, and analyses, making it possible for non- and novice-programmers to learn NLP concepts interactively.
In this research, we derived a non–paralyzable dead time
equation shows the relation between the dead time and those factors.
This equation shows the dead time as function of the applied
voltage, pressure, temperature, dimensions of counter tube and type
of the gas.
Nonlinear conjugate gradient (CG) method holds an important role in solving large-scale unconstrained optimization problems. In this paper, we suggest a new modification of CG coefficient �� that satisfies sufficient descent condition and possesses global convergence property under strong Wolfe line search. The numerical results show that our new method is more efficient compared with other CG formulas tested.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
