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A Cooperative and Comparative Study of Brain Gliomas Between Syrian and French Patients Reclassified Following WHO Classification 2007

دراسة مشتركة مقارنة للأورام الدبقية في الدماغ بين مجموعتين من المرضى الفرنسيين و السوريين و إعادة تصنيفها حسب تصنيف منظمة الصحة العالمية 2007

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 Publication date 2009
and research's language is العربية
 Created by Shamra Editor




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The 4th edition of WHO classification of CNS tumors introduced important changes in the classification of the tumors of central nervous system, compared with WHO classification 2000. Ten New entities and variants were described; three of them concerned gliomas. Changes in the grading of 7 of these tumors were introduced; two of them concerned gliomas. This study aim reclassify and to compare two series of gliomas, observed in the Syrian and French populations.


Artificial intelligence review:
Research summary
تقدم هذه الدراسة مقارنة بين الأورام الدبقية في الدماغ بين مجموعتين من المرضى السوريين والفرنسيين، وإعادة تصنيفها وفقًا لتصنيف منظمة الصحة العالمية لعام 2007. شملت الدراسة 430 ورمًا دبقيًا، منها 260 ورمًا لدى مرضى سوريين و170 ورمًا لدى مرضى فرنسيين. أظهرت النتائج أن الأورام الدبقية منخفضة الدرجة كانت أكثر شيوعًا في المجموعة السورية (46.2%) مقارنة بالمجموعة الفرنسية (18.8%)، بينما كانت الأورام الدبقية عالية الدرجة أكثر شيوعًا في المجموعة الفرنسية (81.2%) مقارنة بالمجموعة السورية (53.8%). كما تم إعادة تصنيف 10.5% من الأورام الدبقية في المجموعتين، مما أثر على التوقعات الإنذارية لهذه الأورام. تشير الدراسة إلى أن العوامل البيئية أو الجينية قد تلعب دورًا في هذه الفروق، وتدعو إلى إجراء دراسات وبائية مكملة لتوضيح هذه العوامل.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة هامة في فهم الفروق بين الأورام الدبقية في مجموعات سكانية مختلفة، ولكن هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الممكن أن تكون الدراسة أكثر شمولية إذا شملت عددًا أكبر من المرضى من دول أخرى لتعزيز النتائج. ثانيًا، لم يتم التطرق بشكل كافٍ إلى العوامل البيئية والجينية التي قد تفسر الفروق بين المجموعتين، وهو ما يستدعي دراسات مستقبلية أكثر تفصيلًا. أخيرًا، كان من الممكن أن تكون الدراسة أكثر قوة إذا شملت تحليلات جينية أعمق لتحديد الطفرات الجينية المحددة التي قد تكون مسؤولة عن هذه الفروق.
Questions related to the research
  1. ما هو الهدف الرئيسي من هذه الدراسة؟

    الهدف الرئيسي هو إعادة تصنيف الأورام الدبقية ومقارنتها بين مجموعتين من المرضى السوريين والفرنسيين وفقًا لتصنيف منظمة الصحة العالمية لعام 2007.

  2. ما هي الفروق الرئيسية التي وجدت بين المجموعتين السورية والفرنسية؟

    وجدت الدراسة أن الأورام الدبقية منخفضة الدرجة كانت أكثر شيوعًا في المجموعة السورية (46.2%) مقارنة بالمجموعة الفرنسية (18.8%)، بينما كانت الأورام الدبقية عالية الدرجة أكثر شيوعًا في المجموعة الفرنسية (81.2%) مقارنة بالمجموعة السورية (53.8%).

  3. كم نسبة الأورام التي تم إعادة تصنيفها في هذه الدراسة؟

    تمت إعادة تصنيف 10.5% من الأورام الدبقية في المجموعتين.

  4. ما هي التوصيات المستقبلية التي قدمتها الدراسة؟

    توصي الدراسة بإجراء دراسات وبائية مكملة لتوضيح العوامل البيئية والجينية التي قد تفسر الفروق بين المجموعتين.


References used
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification of Tumors of the Central Nervous System, 4th edition, Lyon, France: IARC press; 2007
Kleihues P, Cavanee WK, eds. Pathology and Genetics of Tumors of the Nervous System. Lyon, France: IARC Press; 2000. WHO Classification of tumors
Brat DJ, Parisi JE, Kleinschmidt-DeMasters BK, et al. Surgical Neuropathology update; a review of changes introduced by the WHO classification of tumors of the central nervous system, 4th edition. Arch Pathol Lab med 2008; 132:993-1007
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