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Register a new userAssessment of Different Commercial Brands of Tamoxifen 10 mg TabletsMarketed in Yemen as Anti-breast Cancer
تقييم أقراص تاموكسيفين 10 ملغ لشركات دوائية مختلفة متداولة في سوق الدواء اليمني كمضادة لسرطان الثدي
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Added by
Damascus University ورقة بحثية
Publication date
2009
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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سرطان الثدي أحد أكثر السرطانات شيوعاً عند النساء إِذ إن امرأة واحدة من بين تسع نساء معرضة للإصابة بسرطان الثدي خلال حياتها. يتبع تاموكسيفين كيميائياً إلى زمرة ترانس أيزومر ثلاثي فينل ايتيلين هدفت هذه الدراسة إلى التقييم الكمي و الكيفي لأقراص تاموكسيفين 10 ملغ من شركات دوائية مختلفة مسجلة و مسوقة في اليمن.
Breast cancer is one of the most common cancers in women; one of nine women will have breast cancer in her life time. Tamoxifen is the trans-isomer of a triphenylethylene derivative. The aim of this study is to evaluate the quality and the quantity of the commercial brands of Tamoxifen 10 mg tablets which are registered and marketed in Yemen.
References used
(Marc E. Lippman. Breast cancer, Harrison's principles of internal medicine, 16th edition, pp.516 – 523. McGraw-Hill Companies, Inc. (2005
(Supreme Board of Drugs and Medical Appliance of Yemen(2006). Hankinson Susan E. Endogenous hormones and risk of breast cancer in postmenopausal women. Breast Disease, 24(1):3-15. (2005, 2006
(World Health Organization, Quality assurance of pharmaceuticals, A compendium of guidelines and related materials vol. 2, Good manufacturing practice and inspection, pp 1,101-102. (1999
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A retrospective study included 25 cases with inflammatory breast cancer. The patients were admitted to AL-Assad University Hospital, Lattakia, Syria (average age 55, and range 49-61 years old). The most common clinical signs and symptoms were: erythe
ma 100%, edema 100%, enlarged axillary nodes 100%, Nipple flattened/inverted 96%, warm Breast 92%, Ridges/thickening of breast 84%, Peau d’orange 88%, painful/tender Breast 88%, and Mass 80%. Mammography findings were: an increase in skin thickness 100%, an increased tissue density in the involved breast 100%, and an asymmetric widening of the sub-cutaneous lymphatic vessels 33.33%. 80% of cases were diagnosed as stage IV. All patients received primary neoadjuvant chemotherapy for three cycles. After that a modified radical breast mastectomy and axillary lymph nodes dissection were performed for all patients. The wound edges were closed primarily after dissecting the skin in 76%, for 4 patients 16% a split-thickness skin grafts were performed, and for 2 patients 8% a Latissimus dorsi pedicled myocutaneous flap was performed.
112 patients with suspected breast lesions were investigated using Scintimammography with 99mTc-MIBI, mammography and magnetic resonance to compare the diagnostic accuracy of Scintimammography with that of mammography and magnetic resonance in the d
etecting of primary breast cancer. Excisional biopsy was taken after 7-10 days of Scintimammography. 70 patients were diagnosed with breast cancer; 55 palpable and 15 non-palpable lesions, while 42, 30 palpable and 12 non-palpable were diagnosed as benign lesions. The sensitivity of the three methods were high and approximate (89% by Scintimammography, 90% by mammography and 94% by magnetic resonance), while Scintimammography showed higher specificity (86%) versus 21% for mammography and 50% for magnetic resonance. The high specificity in addition to high positive (91%) and negative (82%) predictive values of Scintimammography resulted in a highly accurate diagnostic (87%) method compared to mammography (64%) and magnetic resonance (78%) procedures. Through the complementary use of Scintimammography it is possible to increase the sensitivity for the detection of breast cancer. In patients in whom the status of a palpable breast mass remains unclear, Scintimammography may help to reduce the amount of unnecessary biopsies.
Fear of a painful dental injection
specially in children is significant barrier to regular visits to the
dentist, so the aim of this study was to assess the efficacy of
primary maxillary second molars anesthesia using lidocaine 10%
nasal spray during restorative cavity preparation.
Background: people with cancer experience great changes in their life as a result of disease, treatment and disease prognosis which affect their quality of life .with the goal of investigating breast cancer patient's quality of life during chemother
apy in Tishreen hospital in Latakia..
Methods: 60 patients were invited to complete the European organization of research and treatment quality of life questionnaire version 3 and breast cancer quality of life module during their early stage of chemotherapy.
Results : the results show that the (73.3%) were under the age of fifty and half of them reported total health status score under (50) which reflects low quality of life in addition to impaired psychological ,social, cognitive and role functioning. Also more than 67% of patient suffered from chemotherapy- related side effects as nausea and vomiting, dyspnea, loss of appetite, insomnia, and fatigue. In addition to variance in quality of life scores according to age, marital status, occupation and level of education without changing of it by educational level. In addition to that the majority of patient had impaired sexual function and upset of hair loss and arm symptoms but with positive and optimistic future.
perspective. No significant differences in quality of life scores were found between urban and rural patients. Conclusion. Health care provider should assess routinely cancer patient quality of life during treatment to ascertain of providing appropriate care with supportive services for all patients
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