Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userA Study of the Correlation between Lymph Nodes Levels and Characteristics of the Lowe Lip Squamous Cell Carcinoma
دراسة العلاقة بين مستويات العقد اللمفية و خصائص السرطان شائك الخلايا في الشفة السفلية
1256
0 14
0
(
0
)
Created by
Shamra Editor
Ask ChatGPT about the research
يعد سرطان الشفة خباثة شائعة نسبياً في منطقة الرأس و العنق، إِذ كثيراً ما يحدث السرطان شائك الخلايا في الشفة السفلية و يرمز له ب Lower Lip Squamous Cell Carcinoma أو LLSCC . هدفت هذه الدراسة إلى تقييم العلاقة بين مستوى العقد اللمفاوية المصاب و كل من مظهر الورم و البعد الأعظمي للورم (T) و درجة تمايز الورم (G).
Cancer of the lip is relatively common malignancy of the head and neck region. Squamous cell carcinoma most frequently occurs in the lower lip (LLSCC) or Lower Lip Squamous Cell Carcinoma. This study aimed to evaluate the correlation between the involved lymph nodes level and the tumor appearance, greatest dimension (T) and its degree of differentiation.
References used
Kornevs. E, Skagers. A, Juris. T. 5 Years Experience With Lower Lip Cancer. Stomatologija, Baltic Dental and Maxillofacial Journal 2005; 3: 95-98
Nuutinen. J, Karja. J. Local and distant metastases in patients with surgically treated squamous cell carcinoma of the lip. ClinOtolaryngol 1981; 6: 415-419
Spitzer. W, Krafft .T. Results of surgical therapy of regional lymph nodes in lower lip cancer. Fortschr Kiefer Gesichtschir1992; 37: 77-78
rate research
Read More
this study Aimes to Investigate CXCR4 expression in primary head
and neck squamous cell carcinomas tumors in all clinical stages and
histological grades, then compare it with control normal oral
epithelial tissues.
Compare metastatic lymph nodes
CXCR4 expression with their
primary HNSCC tumors at high stages which associated with
metastatic lymph nodes.
Aim of study: study of the differences in the protein expression of
Cyclin-dependent Kinase CdK1, CdK2 in Oral Squamous Cell
Carcinoma (OSCC) and in clinically- normal oral mucosa.
Background & Objective: This immunohistochemical study is to investigate the correlation between p53 & Ki67 and the grade of malignancy of squamous cell carcinoma, to estimate functional behavior of the cancerous cell by Ck17, and to compare the resu
lts with the histological grading.
Methods & Materials: 64 samples (biopsies) were chosen to check for p53, Ki67 & Ck17 at department of oral histology and pathology between 2002- 2009.
Conclusion: There is a strong positive correlation between the degree of malignancy and the signs of cellular atypism (morphological changes) and the immunhistochemical positivity specially p53 and Ki67, and there is a strong negative correlation between the positivity of p53, Ki67 and the plasmolymphatic
infiltrate. We must be sure of the correct diagnosis of squamous cell carcinoma by histological and immunohistochemical examination, and attention should be given to use more than one immune reactive.
The protein p53 is the guardian of the cell gene contents from changes, and the
gene that produces it is called Tumor Suppressor Gene which mutates in 50% of Squamous cell
carcinoma’s cases producing defective protein .Studies have not detailed the
expression ratio of the
defective protein Within the cancer cells, also studies have less details about the cases which did not show
a mutated protein.
Cancer stem cells in solid tumors are a "rare" group of cells and
their role in carcinogenesis has been proven during the past few
years. The pursuit for specific oral epithelial stem cell surface
markers leads to the identification of markers su
ch as CD44
and Bmi-1. The combination between CD44 which has been
considered a potential prognostic marker for cancer stem cells in
Head and Neck Squamous Cell Carcinoma (HNSCC), and Bmi-1
the pluripotency stemness marker may lead to identify the cells
sharing the properties of both markers and could give a closer look
into its appearance and density in the tissue. The aim of this study
was to study the percent of cells stained positive for both markers
and the histological grade of (HNSCC) and the anatomic location
of the tumor. Statistical analysis showed that higher density of
positive stained cells for both markers was in the severe grade of
the tumor, whereas the second higher ratio was in the mild grade
then the moderate , there was no significant association between the density of cells and the anatomical location. Our results suggest that the two markers together could be used as prognostic factors for patients with even mild grade SCC, which might help in prediction of recurrence.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
