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The Relation Between Thrombus , Spontaneous Echo Contrast , And Left Atrial Appendage Velocity In Patients With Ischemic Stroke

العلاقة بين الخثار, التباين العفوي الصدوي, و سرعة الجريان عبر لسينة الأذينة اليسرى عند مرضى النشبة الدماغية الإقفارية

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 Publication date 2015
and research's language is العربية
 Created by Shamra Editor




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Cardiogenic embolism can be identified in at least 15% of ischemic stroke patients, left atrial appendage is believed to be the place where thrombi is performed, then goes to systemic circulation causing embolic accident . In this search we study the function of left atrial appendage by pulse Doppler within the proximal third of the appendage in patients with ischemic stroke. Thrombus was defined as a discrete echocardiographically dens mass within the body of atrium or the appendage, with a different echocardiographically density than the adjacent endothelium . Spontaneous echo contrast was defined as high density flow due to low flow condition , which remains stable with changes in gain setting . In conclusion , the velocities which recorded in patients with ischemic stroke were lower in comparison with other patients , and it was significant lower in patients with spontaneous echo contrast or atrial fibrillation .


Artificial intelligence review:
Research summary
تناولت هذه الدراسة العلاقة بين الخثار، التباين العفوي الصدوي، وسرعة الجريان عبر لسينة الأذينة اليسرى عند مرضى النشبة الدماغية الإقفارية. تم تعريف الخثار ككتلة صدوية واضحة الحدود ومتمايزة عن الجدران القريبة، بينما تم تعريف التباين العفوي كخيوط صدوية كثيفة تبقى حتى بعد زيادة وظيفة التصفية وتخفيض الضجيج الخارجي. أظهرت النتائج أن سرعات الجريان عبر اللسينة اليسرى كانت منخفضة عند مرضى النشبة الإقفارية الذين لديهم خثار بالمقارنة مع بقية المرضى، وكانت أقل بشكل جدي عند المرضى الذين لديهم تباين عفوي أو رجفان أذيني. الدراسة شملت 44 مريضًا، وتم إجراء الفحص باستخدام الإيكو عبر المري. تم تحليل البيانات باستخدام اختبارات إحصائية متعددة، وأظهرت النتائج وجود علاقة هامة بين انخفاض سرعة الجريان وحدوث الخثار والتباين العفوي الصدوي. الاستنتاجات أشارت إلى أن سرعة الجريان عبر اللسينة اليسرى تعتبر مؤشرًا هامًا لخطورة حدوث الخثار والحوادث الصمية، مما يستدعي المزيد من الدراسات لتحديد استطباب التمييع الوقائي اعتمادًا على وظيفة اللسينة اليسرى.
Critical review
دراسة نقدية: الدراسة تقدم إسهامًا مهمًا في فهم العلاقة بين الخثار وسرعة الجريان عبر اللسينة اليسرى عند مرضى النشبة الدماغية الإقفارية. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة كان صغيرًا نسبيًا (44 مريضًا)، مما قد يؤثر على قوة النتائج وإمكانية تعميمها. ثانياً، لم تتناول الدراسة العوامل الأخرى المحتملة التي قد تؤثر على سرعة الجريان مثل الأدوية المستخدمة أو الحالات المرضية الأخرى. ثالثاً، كان من الممكن تقديم تحليل أكثر تفصيلاً للعوامل الديموغرافية والسريرية للمرضى. على الرغم من هذه النقاط، فإن الدراسة تفتح المجال لمزيد من الأبحاث في هذا المجال وتقدم توصيات هامة للوقاية من الحوادث الصمية.
Questions related to the research
  1. ما هي العلاقة بين سرعة الجريان عبر اللسينة اليسرى وحدوث الخثار عند مرضى النشبة الدماغية الإقفارية؟

    أظهرت الدراسة أن سرعات الجريان عبر اللسينة اليسرى كانت منخفضة بشكل كبير عند المرضى الذين لديهم خثار بالمقارنة مع المرضى الآخرين.

  2. كيف تم تعريف التباين العفوي الصدوي في الدراسة؟

    تم تعريف التباين العفوي الصدوي كخيوط صدوية كثيفة تبقى حتى بعد زيادة وظيفة التصفية وتخفيض الضجيج الخارجي.

  3. ما هي أهمية سرعة الجريان عبر اللسينة اليسرى في تقييم خطورة حدوث الخثار؟

    سرعة الجريان عبر اللسينة اليسرى تعتبر مؤشرًا هامًا لخطورة حدوث الخثار والحوادث الصمية، حيث تزداد الخطورة مع انخفاض السرعات المقاسة.

  4. ما هي التوصيات التي قدمتها الدراسة بناءً على النتائج؟

    أوصت الدراسة بإجراء المزيد من الأبحاث لتحديد استطباب التمييع الوقائي اعتمادًا على وظيفة اللسينة اليسرى بشكل مستقل عن العوامل الأخرى.


References used
FEIGIN,V.L.;FOROUZANFAR,M.H.;KRISHNAMRTHI,R. et al Global and regional burden of stroke during 1990 – 2010:findings from the Global Burden of Disease study . Lancet 18,383(9913); 2010 ,245 – 254
COMESS K.A., DEROOK F.A., BEACH K.W., Transesophageal echocardiography and carotid ultrasound in patients with cerebral ischemia: Prevalence of findings and recurrent stroke risk. J Am CollCardiol 1994; 23:1598-1603
N M AL-SAADY, O AOBEL, A J CAMM ,Left atrial appendage: structure, function, and rolein thromboembolism. journal of Heart1999;82:547–555
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