Bladder cancer is the most common malignancy of the urinary
tract, and has the fastest rate of recurrence which gives it high
prevalence of tumors all over the world. Early diagnosis is very
important for treatment efficacy, prevent tumor progress
ion and
prolong survival period, so many urinary markers have been
studied but early diagnosis of carcinoma of bladder remains a
challenge. Survivin is a member of the inhibitor of apoptosis
protein family (IAPs), whose irregular expression is associated with
tumor cell proliferation, progression, angiogenesis, therapeutic
resistance, and poor prognosis.
The urinary bladder malignant neoplasms are the member of the most common malignancies through the world. The diagnosis of bladder carcinoma in its late advanced development evokes the surgeon to radical cystectomy. The studying points are the correc
t diagnosis, histological types, histological grade and pathological stage of the disease, in order to achieve the best treatment and prognosis. The morphological examination of bladder biopsies were done routinely, the total biopsies were 250, obtained from 194 patients (172 male, 22 female). The low grade tumor were 41, and high grade 149.although the early stage diagnosis were 138, and the late stage 66, always we must detect the lesion early for the best life after the treatment. may be useful in the future study and detect the reason of predominance the male gender in bladder tumor, also we hope, that we can discover the role of inflammation in arising the neoplasm of bladder.
