Asthma exacerbations can be frequent and range in severity from relatively mild to
status asthmaticus. While the efficacy of intravenous MgSO4 hasbeen demonstrated, the
informations available on its inhaled role still low and conflicting, so the st
udy aim to
investigate the effect of thecombinationof MgSO4and salbutamol in the management of
acute asthma attack.
A randomized clinical trial was conducted on 76 patients, divided into two groups:
experimental (40) and control (36) patients. The trial received nebulised salbutamol with
magnesium sulphate and control nebulised salbutamol with saline serum 0.9% on three
sessions in 20 minutes. Signs of respiratory distress, wheezing, respiratory rate, pulse,
Sao2 and PEF were assessed.
Magnesium sulphate showed a significant effect in improving respiratory rate, Sao2
and PEF starting from the 20th minute( P <0.05), but did not observe the effect of MgSO4
in improving signs of respiratory distress, pulse and wheezing(P> 0,05), no side effects
attributed to magnesium sulphate were observed.Inhaled MgSO4, incombination with
salbutamol, appears to have benefits in the treatment of acute asthma attack.
COPD is a major public health problem , and it results with an extensive social and
economical burden on both the patient and his family on one hand and the healthcare
system on the other . Despite the great advances in the management of patients w
ith COPD
, the use of the optimal treatment of the proposed treatment options is still being discussed ,
and Must achieve greater benefit for both patients and the healthcare system .
This research is designed to study and compare the effect of the combination
(salbutamol and ipratropium bromide) with the effect of salbutamol alone in the treatment
of patients with stable COPD , by studying and comparing the improvement in the forced
expiratory volume in the first second (FEV1) and in forced vital capacity
( FVC) after a month of a treatment .
The study included 80 patients (53 males and 27 females), the patients were between
45-81 years of age , 63 patients were smokers and 17 were nonsmokers.
The study showed that after a month on therapy , for patients treated with the
combination (salbutamol + ipratropium bromide) the increasing in FEV1 was 0.35 liters
and in FVC was 0.61-liter , while , for the patients treated with salbutamol alone , the
increasing in FEV1 was 0.28 liters and FVC was 0.48-liter .
We concluded that a combination of ipratropium bromide and salbutamol is more
effective at improving pulmonary function than salbutamol alone.
This study was done to determine whether use of nebulized salbutamol therapy for
treatment of an acute attack of asthma in children is associated with hypokalaemia and if
so what is its frequency, severity and what is accompanying clinical symptoms
103 child,
aged 3 years to 14 years with asthma attack, treated with three doses of nebulized
salbutamol 0.15mg/kg, every 20 min participated in the study. Blood for serum potassium
was obtained at the beginning and after three doses of nebulized salbutamol therapy.The
mean serum potassium level decreased from 3.94 mEq/L to 3.28 mEq/L (P < 0.05). A
decrease in serum potassium concentration was noted in 93 child (90.3%).). Mild
hypokalemia formed the highest proportion in 43child (41.7%) followed by moderate
hypokalemia in 28 child( 27.2%). Severe hypokalemia did not happen.This decrease was
accompanied with clinical symptoms (palpitations 23,muscle weakness 21,nausea 15,
headache 12,myalgia 11,vomiting 9).These symptoms were moreclosely to moderate
hypokalemia.
A study of the effect of electrostatic charge that is generated in actuator due to drying methods on the delivered dose of metered dose inhaler has been done in tow cases:
Washing actuator and drying it by a clothe.
Washing actuator and let it dry
alone.
A study has been done on metered dose inhaler containing salbutmaol sulfate and manufactured by a local company.
The results show the importance of drying methods on the delivered dose, the delivered doses of metered dose inhaler after washing the actuator and dry it by a clothe hadn't been achieved the USP-34 requirements (out of range 75-125%), while the delivered doses after washing actuator and let it dry alone had been achieved the USP-34 requirements.
The difference in results between the two cases belong to electrostatic charge generated in actuator due to drying methods